The Role of Environmental Factors in the Etiology of Nonsyndromic Orofacial Clefts

Autor: Mekonen Eshete, Taye Hailu, Abiye Hailu, Miliard Derbew, Shiferaw Degu, Peter A. Mossey, Fikre Abate, Azeez Butali, Yohannes Demissie, Tamara Bush, Wakgari Deressa, Paul Gravem

Publikováno v: Journal of Craniofacial Surgery. 31:113-116

BACKGROUND Nonsyndromic orofacial clefts (NSOFCs) represent the most common congenital anomalies in the head and neck region. Multiple factors contribute to the occurrence of this anomaly. The etiology of NSOFCs in the Ethiopian population has not be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c912329ecd7d43df2b7435774eea3f5b
https://doi.org/10.1097/scs.0000000000005924

The prevalence, penetrance, and expressivity of etiologic IRF6 variants in orofacial clefts patients from sub‐Saharan Africa

Autor: Jeffrey C. Murray, Lord J.J. Gowans, Tamara Busch, Peter A. Mossey, Peter Twumasi, Wasiu Lanre Adeyemo, Rahman Braimah, Pius Agbenorku, Babatunde S. Aregbesola, Gyikua Plange-Rhule, Fareed K. N. Arthur, Solomon Obiri-Yeboah, Alexander Acheampong Oti, James Olutayo, Azeez Butali, Paa Ekow Hoyte-Williams, Taye Hailu, Peter Donkor, Mekonen Eshete, Fikre Abate

Publikováno v: Molecular Genetics & Genomic Medicine

Background Orofacial clefts are congenital malformations of the orofacial region, with a global incidence of one per 700 live births. Interferon Regulatory Factor 6 (IRF6) (OMIM:607199) gene has been associated with the etiology of both syndromic and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb78d1eb1955aad763df3198216b45a
http://europepmc.org/articles/PMC5370218

Foreign Bodies Simulating a Congenital Palatal Fistula and Vascular Anomaly

Autor: Mulualem Gessesse, Fikre Abate, Mekonen Eshete, Azeez Butali, Taye Hailu

Publikováno v: Case Reports in Dentistry
Case Reports in Dentistry, Vol 2015 (2015)

Foreign bodies embedded in the palate are uncommon findings and may occasionally mimic oral lesions. In the majority of the cases, foreign body embedment in the palate happens in infants and children who are unable to give history. Physical examinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3c75f97fee13d23c355a484e1b8f00
https://doi.org/10.1155/2015/387092

Novel IRF6 mutations in families with Van Der Woude syndrome and popliteal pterygium syndrome from sub-Saharan Africa

Autor: Jeffrey C. Murray, Azeez Butali, Mulualem Gesses, Akinola L Ladeinde, Jennifer Rigdon, Christian Ibezi Emeka, Ramat Oyebunmi Braimah, Babatunde S. Aregbesola, Paul Gravem, Taye Hailu, Dee Ann Even, Mobolanle O. Ogunlewe, Lauren A. L. Gaines, Peter A. Mossey, Fikre Abate, Milliard Deribew, Ibrahim Mohammed, Adebowale Adeyemo, Wasiu Lanre Adeyemo, Mekonen Eshete, Olutayo James

Publikováno v: Molecular Genetics & Genomic Medicine

Orofacial clefts (OFC) are complex genetic traits that are often classified as syndromic or nonsyndromic clefts. Currently, there are over 500 types of syndromic clefts in the Online Mendelian Inheritance in Man (OMIM) database, of which Van der Woud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1d9c995af3ce8f8fdd0bb286064eed
http://europepmc.org/articles/PMC4049366

A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13

Autor: Deepti Jain, Azeez Butali, Dora Rivera Valencia, Jacqueline T. Hecht, Carmencita Padilla, Rolv T. Lie, Kaare Christensen, Ramat Oyebunmi Braimah, Toby Goldstein McHenry, Jenna C. Carlson, John R. Shaffer, Elizabeth J. Leslie, Luz Consuelo Valencia-Ramirez, Iêda M. Orioli, Peter A. Mossey, Lina M. Moreno, Mine Koruyucu, Wasiu Lanre Adeyemo, Fernando A. Poletta, Cecelia A. Laurie, Judith M. Resick, Eleanor Feingold, Allen J. Wilcox, Paul A. Romitti, L. Leigh Field, Babatunde S. Aregbesola, Alexandre R. Vieira, Susan H. Blanton, Juan C. Mereb, Fikre Abate, Cathy C. Laurie, Seth M. Weinberg, George L. Wehby, Eduardo E. Castilla, Flávia Martinez de Carvalho, Katherine Neiswanger, Ana Maria Lopez-Palacio, Lian Ma, Figen Seymen, Andrew C. Lidral, Andrew E. Czeizel, Jeffrey C. Murray, Beth Emanuele, Kimberly F. Doheny, Mekonen Eshete, Carla A. Sanchez, Jennifer Jacobs, Mary L. Marazita, Olutayo James, Frederic W.-B. Deleyiannis, Javier Enríquez de Salamanca, Carmen J. Buxó, Mauricio Arcos-Burgos, Eva Maria Cutiongco-de la Paz, Ronald G. Munger

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Leslie, E J, Carlson, J C, Shaffer, J R, Feingold, E, Wehby, G, Laurie, C A, Jain, D, Laurie, C C, Doheny, K F, McHenry, T, Resick, J, Sanchez, C, Jacobs, J, Emanuele, B, Vieira, A R, Neiswanger, K, Lidral, A C, Valencia-Ramirez, L C, Lopez-Palacio, A M, Valencia, D R, Arcos-Burgos, M, Czeizel, A E, Field, L L, Padilla, C D, Cutiongco-de la Paz, E M C, Deleyiannis, F, Christensen, K, Munger, R G, Lie, R T, Wilcox, A, Romitti, P A, Castilla, E E, Mereb, J C, Poletta, F A, Orioli, I M, Carvalho, F M, Hecht, J T, Blanton, S H, Buxó, C J, Butali, A, Mossey, P A, Adeyemo, W L, James, O, Braimah, R O, Aregbesola, B S, Eshete, M A, Abate, F, Koruyucu, M, Seymen, F, Ma, L, de Salamanca, J E, Weinberg, S M, Moreno, L, Murray, J C & Marazita, M L 2016, ' A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13 ', Human Molecular Genetics, vol. 25, no. 13, pp. 2862-2872 . https://doi.org/10.1093/hmg/ddw104

Orofacial clefts (OFCs), which include non-syndromic cleft lip with or without cleft palate (CL/P), are among the most common birth defects in humans, affecting approximately 1 in 700 newborns. CL/P is phenotypically heterogeneous and has a complex e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f111356840c84c01dedd5fe9ecb40a
https://doi.org/10.1093/hmg/ddw104