Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Fikadu G. Tafesse"'
Autor:
Corinna A. Kulicke, Gwendolyn M. Swarbrick, Nicole A. Ladd, Meghan Cansler, Megan Null, Aneta Worley, Chance Lemon, Tania Ahmed, Joshua Bennett, Taylor N. Lust, Chelsea M. Heisler, Megan E. Huber, Jason R. Krawic, Laurisa M. Ankley, Savannah K. McBride, Fikadu G. Tafesse, Andrew J. Olive, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation molecules, evidence supports multiple, complementary MR1 antigen presentation pathways
Externí odkaz:
https://doaj.org/article/a188a5d473ac493d8d7f9aa7fe4c7e44
Autor:
Xammy Huu Nguyenla, Timothy A. Bates, Mila Trank-Greene, Mastura Wahedi, Fikadu G. Tafesse, Marcel Curlin
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 6, Pp 1282-1283 (2024)
Because novel SARS-CoV-2 variants continue to emerge, immunogenicity of XBB.1.5 monovalent vaccines against live clinical isolates needs to be evaluated. We report boosting of IgG (2.1×), IgA (1.5×), and total IgG/A/M (1.7×) targeting the spike re
Externí odkaz:
https://doaj.org/article/d39ae1a6929949d881b391b9326d7cf2
Autor:
Scotland E. Farley, Jennifer E. Kyle, Hans C. Leier, Lisa M. Bramer, Jules B. Weinstein, Timothy A. Bates, Joon-Yong Lee, Thomas O. Metz, Carsten Schultz, Fikadu G. Tafesse
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Here, Farley et al. perform untargeted lipidomics to assess how SARS-CoV-2 rewires host lipid metabolism. SARS-CoV-2 viral proteins specifically induce lipid droplet formation and dramatically change lipid metabolism to support infection; interfering
Externí odkaz:
https://doaj.org/article/8045e4b0f34b44b689fa4b922259ce55
Autor:
Timothy A. Bates, Hans C. Leier, Savannah K. McBride, Devin Schoen, Zoe L. Lyski, David X. Lee, William B. Messer, Marcel E. Curlin, Fikadu G. Tafesse
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
As the COVID-19 pandemic continues, long-term immunity against SARS-CoV-2 will be important globally. Official weekly cases have not dropped below 2 million since September of 2020, and continued emergence of novel variants has created a moving targe
Externí odkaz:
https://doaj.org/article/0f753a751bde4d07a51f23430735ae29
Autor:
Xin Song, Felicity J. Coulter, Ming Yang, Jessica L. Smith, Fikadu G. Tafesse, William B. Messer, John H. Reif
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Access to fast and reliable nucleic acid testing continues to play a key role in controlling the COVID-19 pandemic, especially in the context of increased vaccine break-through risks due to new variants. We report a rapid, low-cost (~ 2 USD)
Externí odkaz:
https://doaj.org/article/404aec15e5864b4da7c4cf9f4bbc274e
Autor:
Tesfaye Gelanew, Berhanu Seyoum, Andargachew Mulu, Adane Mihret, Markos Abebe, Liya Wassie, Baye Gelaw, Abebe Sorsa, Yared Merid, Yilkal Muchie, Zelalem Teklemariam, Bezalem Tesfaye, Mahlet Osman, Gutema Jebessa, Abay Atinafu, Tsegaye Hailu, Antenehe Habte, Dagaga Kenea, Anteneh Gadisa, Desalegn Admasu, Emnet Tesfaye, Timothy A. Bates, Jote Tafese Bulcha, Rea Tschopp, Dareskedar Tsehay, Kim Mullholand, Rawleigh Howe, Abebe Genetu, Fikadu G. Tafesse, Alemseged Abdissa
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background COVID-19 pandemic has a devastating impact on the economies and health care system of sub-Saharan Africa. Healthcare workers (HWs), the main actors of the health system, are at higher risk because of their occupation. Serology-bas
Externí odkaz:
https://doaj.org/article/5b38ae514d144b6badd56dfc235c9895
Autor:
Timothy A. Bates, Hans C. Leier, Zoe L. Lyski, Savannah K. McBride, Felicity J. Coulter, Jules B. Weinstein, James R. Goodman, Zhengchun Lu, Sarah A. R. Siegel, Peter Sullivan, Matt Strnad, Amanda E. Brunton, David X. Lee, Andrew C. Adey, Benjamin N. Bimber, Brian J. O’Roak, Marcel E. Curlin, William B. Messer, Fikadu G. Tafesse
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Here, the authors show that neutralization of human sera from both BNT162b2 vaccine recipients and from convalescent COVID-19 patients is less efficient against SARS- CoV-2 variants B.1.1.7 and B.1.351 and negatively associated with patient age.
Externí odkaz:
https://doaj.org/article/bb8db59a951140a893c150893245d2b7
Autor:
Jules B. Weinstein, Timothy A. Bates, Hans C. Leier, Savannah K. McBride, Eric Barklis, Fikadu G. Tafesse
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103960- (2022)
Summary: The spike glycoprotein of SARS-CoV-2 engages with human ACE 2 to facilitate infection. Here, we describe an alpaca-derived heavy chain antibody fragment (VHH), saRBD-1, that disrupts this interaction by competitively binding to the spike pro
Externí odkaz:
https://doaj.org/article/70a99d0c5b10463697388cb36e8ef93a
Autor:
Hans C. Leier, Jules B. Weinstein, Jennifer E. Kyle, Joon-Yong Lee, Lisa M. Bramer, Kelly G. Stratton, Douglas Kempthorne, Aaron R. Navratil, Endale G. Tafesse, Thorsten Hornemann, William B. Messer, Edward A. Dennis, Thomas O. Metz, Eric Barklis, Fikadu G. Tafesse
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Zika virus (ZIKV) remodels intracellular membranes for replication, but the role of different lipid types for infection and disease is unclear. Here, the authors perform lipidomics, show perturbation of the lipid network during ZIKV infection and sho
Externí odkaz:
https://doaj.org/article/e3700eeb09074ab692ee327211963128
Autor:
Bryan D. Bryson, Tracy R. Rosebrock, Fikadu G. Tafesse, Christopher Y. Itoh, Armel Nibasumba, Gregory H. Babunovic, Bjorn Corleis, Constance Martin, Caroline Keegan, Priscila Andrade, Susan Realegeno, Douglas Kwon, Robert L. Modlin, Sarah M. Fortune
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
GM-CSF has been implicated in Mycobacterium tuberculosis (Mtb) host control. Here, the authors show that activation of GM-CSF discriminates Mtb-restrictive from -permissive macrophages while co-infection with HIV disrupts GM-CSF-mediated signaling, r
Externí odkaz:
https://doaj.org/article/7b1cd08cca8c4de48969bd62ffdea2d7