Recombinant expression and antigenicity of two peptide families of neurotoxins from Androctonus sp.

Autor: Samuel Cardoso-Arenas, Herlinda Clement, Iván Arenas, Felipe Olvera, Fernando Zamudio, Figen Caliskan, Ligia Luz Corrales-García, Gerardo Corzo

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 28 (2022)

Abstract Background: Scorpion neurotoxins such as those that modify the mammalian voltage-gated sodium ion channels (Nav) are the main responsible for scorpion envenomation. Their neutralization is crucial in the production of antivenoms against scor

Externí odkaz: https://doaj.org/article/c00a023288d34bedb97e84ea3ae59063

An in vitro methodology for discovering broadly-neutralizing monoclonal antibodies

Autor: Andreas Hougaard Laustsen, Manuela Berto Pucca, Christoffer V. Sørensen, Figen Caliskan, Rahel Janke, Line Ledsgaard, Erwin M. Schoof, Jonas A. Jürgensen, Shirin Ahmadi

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Ahmadi, S, Pucca, M B, Jürgensen, J A, Janke, R, Ledsgaard, L, Schoof, E M, Sørensen, C V, Çalışkan, F & Laustsen, A H 2020, ' An in vitro methodology for discovering broadly-neutralizing monoclonal antibodies ', Scientific Reports, vol. 10, no. 1, 10765 . https://doi.org/10.1038/s41598-020-67654-7

Broadly-neutralizing monoclonal antibodies are of high therapeutic utility against infectious diseases caused by bacteria and viruses, as well as different types of intoxications. Snakebite envenoming is one such debilitating pathology, which is curr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8566aa682938caaaa7b2a9f0ceb19b
http://link.springer.com/article/10.1038/s41598-020-67654-7

Scorpion Venom: Detriments and Benefits

Autor: Andreas Hougaard Laustsen, Manuela Berto Pucca, Lídia M. Argemí, Julius M. Knerr, Figen Caliskan, Shirin Ahmadi, Karla de Castro Figueiredo Bordon, Eliane Candiani Arantes, Felipe Augusto Cerni

Publikováno v: Ahmadi, S, Knerr, J M, Argemi, L, Bordon, K C F, Pucca, M B, Cerni, F A, Arantes, E C, Çalışkan, F & Laustsen, A H 2020, ' Scorpion Venom: Detriments and Benefits ', Biomedicines, vol. 8, no. 5, 118 . https://doi.org/10.3390/biomedicines8050118
Biomedicines
Biomedicines, Vol 8, Iss 118, p 118 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Scorpion venom may cause severe medical complications and untimely death if injected into the human body. Neurotoxins are the main components of scorpion venom that are known to be responsible for the pathological manifestations of envenoming. Beside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d913ab04e8fb05b4c0318753aabf8b
https://orbit.dtu.dk/en/publications/fe8ed231-f852-4432-a779-9eb9b7875347

Production of an alkaline protease using Bacillus pumilus D3 without inactivation by SDS, its characterization and purification

Autor: Serap Gedikli, Burcin Ozcelik, Figen Caliskan, Ahmet Çabuk, Pınar Aytar, Ezgi Yardımcı

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry. 29:388-396

In this study, protease-producing capacity of Bacillus pumilus D3, isolated from hydrocarbon contaminated soil, was evaluated and optimized. Optimum growing conditions for B. pumilus D3 in terms of protease production were determined as 1% optimum in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb559d40fb74556993e1bb55e77fa73
https://doi.org/10.3109/14756366.2013.788503

The Mediterranean scorpion Mesobuthus gibbosus (Scorpiones, Buthidae): transcriptome analysis and organization of the genome encoding chlorotoxin-like peptides

Autor: Jan Tytgat, Elia Diego-García, Figen Caliskan

Publikováno v: BMC Genomics

Background Transcrof toxin genes of scorpion species have been published. Up to this moment, no information on the gene characterization of M. gibbosus is available. Results This study provides the first insight into gene expression in venom glands f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9c1547a4789a2120cf9adc54356d2e
https://doi.org/10.1186/1471-2164-15-295