Inhibiting RIPK1 Kinase Activity Is Protective in Experimental Models of COPD

Autor: Hannelore P. Van Eeckhoutte, Chantal Donovan, Richard Kim, Haroon Khan, Ranjith Jayaraman, Yves Dondelinger, Tom Delanghe, Allison Beal, Brad Geddes, John Bertin, Tom Vanden Berghe, Peter Vandenabeele, Bart Vanaudenaerde, Dieter Deforce, Sonja Skevin, Filip Van Nieuwerburgh, Fien Verhamme, Guy Joos, Guy Brusselle, Mathieu Bertrand, Philip Hansbro, Ken Bracke

Publikováno v: B21. BASIC, CLINICAL, AND TRANSLATIONAL COPD STUDIES: THE ONGOING HUNT FOR UNDERLYING MECHANISMS AND THERAPEUTIC TARGETS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fcc9cfd73ac41a2772ddb0cdb5a87f
https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2407

Expression of Receptor Interacting Protein Kinase-3 and Mixed Lineage Kinase Domain-Like Protein in Patients with COPD

Autor: T Buyle-Huybrecht, Tom Vanden Berghe, Hannelore Van Eeckhoutte, Peter Vandenabeele, Fien Verhamme, Guy Brusselle, Ken R. Bracke

Publikováno v: C63. MECHANISTIC STUDIES IN COPD.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afee7df3576b23f98d287315252b685d
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5363

Heritability and genome-wide association study of diffusing capacity of the lung (DLCO)

Autor: Daan Loth, Fien Verhamme, Guy Brusselle, Fanfgui Sun, Josée Dupuis, Ken R. Bracke, George O'Conner, Natalie Terzikhan, Hieab H.H. Adams, Lies Lahousse, Bruno H. Stricker

Publikováno v: Genes and environment.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b45386dd4b25a96ecdc1517483ffc8a9
https://doi.org/10.1183/13993003.congress-2018.oa2189

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Autor: Wenbo Tang, Stephen B. Kritchevsky, Ian P. Hall, Alexessander Couto Alves, Henry Völzke, Kim de Jong, Sina A. Gharib, Louise V. Wain, Adaikalavan Ramasamy, John M. Starr, Tatijana Zemunik, André G. Uitterlinden, Isabelle Pin, A. Bill Musk, Lina Zgaga, Ernst Omenaas, Mi Kyeong Lee, Nadia N. Hansel, Lewis J. Smith, Dana B. Hancock, Anne Viljanen, Anneli Pouta, Erik Melén, Nora Franceschini, Susan Campbell, Alicja R. Rudnicka, Melissa E. Garcia, Jemma B. Wilk, Igor Rudan, John Beilby, Fernando Rivadeneira, Gudny Eiriksdottir, Lenore J. Launer, Kristin M. Burkart, Ozren Polasek, Pieter S. Hiemstra, Regina Hampel, Jerome I. Rotter, Markku Heliövaara, Harald Grallert, Tim D. Spector, Andrew P. Morris, Jennifer E. Huffman, Pau Navarro, Jing Hua Zhao, Robert A. Scott, Bruno H. Stricker, Christopher Oldmeadow, Yeon-Mok Oh, Christian Gieger, Tove Fall, Caroline Hayward, Rodney J. Scott, Mika Kähönen, Vilmundur Gudnason, Guy Brusselle, Stefan Karrasch, Anne B. Newman, Alan James, Ida Surakka, Peter K. Joshi, R. Graham Barr, Fien Verhamme, Alexander Teumer, Ulf Gyllensten, Joohon Sung, Marjolein J. Peters, Ryan L. Minster, Kirsi H. Pietiläinen, Ian J. Deary, Lorna M. Lopez, Matthias Wjst, Myriam Fornage, Susan Redline, Wei Gao, Taina Rantanen, David J. Lederer, Gail Davies, Mary K. Wojczynski, Kari E. North, Beate Koch, Guo Li, George T. O'Connor, Blair H. Smith, Harry Campbell, Wendy B. White, Juha Pekkanen, Eva Albrecht, Sven Gläser, Joyce B. J. van Meurs, Stephen S. Rich, Wendy L. McArdle, Deborah Jarvis, Ani Manichaikul, Pirro G. Hysi, Christopher J Hammond, Erik Ingelsson, Albert V. Smith, John Attia, O. Dale Williams, Tamara B. Harris, Susan R. Heckbert, Josée Dupuis, Bruce M. Psaty, Åsa Johansson, Xin-Qun Wang, Samuli Ripatti, Woo Jin Kim, Patricia A. Cassano, H. Marike Boezen, David J. Porteous, Esteban G. Burchard, Kurt Lohman, Ivana Kolcic, Lies Lahousse, James F. Wilson, Dirkje S. Postma, Holly Trochet, Nicholas J. Wareham, Ana Viñuela, María Soler Artigas, Lars Lind, Jennie Hui, Bharat Thyagarajan, Judith M. Vonk, Marcy F. Petrini, Bonnie R. Joubert, Marjo-Riitta Järvelin, Xiangjun Gu, Claudia Flexeder, Generation Scotland, Sarah H. Wild, Nicholas D. Hastie, Thomas Lumley, Veronique Vitart, Laura R. Loehr, Joachim Heinrich, Yongmei Liu, Akshay Sood, Tess D. Pottinger, Alan F. Wright, Albert Hofman, Rajesh Kumar, Cisca Wijmenga, Elizabeth G. Holliday, Ian Sayers, David P. Strachan, Martin D. Tobin, Stefan Enroth, Thor Aspelund, Leslie A. Lange, Qing Duan, Daan W. Loth, Ken R. Bracke, Nathan C. Gaddis, David Couper, Stephanie J. London, Alanna C. Morrison, Holger Schulz, Jaakko Kaprio

Publikováno v: Nature Genetics, 46(7), 669-677. Nature Publishing Group
Nature Genetics, 46(7), 669-677

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611ff780062642f5d40293514c9d3b6e
https://doi.org/10.1038/ng.3011

Transcriptome analysis of the human airway epithelium duringin vitrodifferentiation

Autor: Michael Lindner, Jürgen Behr, Fien Verhamme, Oliver Eickelberg, Andrea C. Schamberger

Publikováno v: 3.2 Airway Cell Biology and Immunopathology.

Background: The human airway epithelium is composed of a pseudostratified layer of basal, secretory, ciliated, and neuroendocrine cells. Basal cells serve as progenitor cells for the other epithelial cell types, a process which can be recapitulated b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::337c9c6910f7068acfb00c1af9a135c4
https://doi.org/10.1183/13993003.congress-2016.pa3993