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Double-stranded polynucleotides as interferon inducers

Autor: Maurice R. Hilleman, Nemes Mm, Lampson Gp, Alfred A. Tytell, Field Ak

Publikováno v: The Journal of General Physiology

A discussion of factors considered influential in making a polynucleotide an efficient inducer of interferon was presented. These factors were double-strandedness of the polynucleotides, the sugar moiety of the polynucleotides, thermal stability, res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93535de1d5811aa8e21697e4e267c722
https://pubmed.ncbi.nlm.nih.gov/19873677

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Safety Assessment of Poly I: C in NZB/NZW Mice

Autor: B. Mendlowski, Maurice R. Hilleman, Field Ak, Alfred A. Tytell

Publikováno v: Experimental Biology and Medicine. 148:476-483

SummaryThe present report confirms the findings by Steinberg et al. (9) that repeated intraperitoneal injections of poly I:C (3 μg/g, three times per wk, 40-52 doses) enhanced the incidence and severity of glomer-ular lesions that occur spontaneousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aed485264071abee1f56bb5208860c71
https://doi.org/10.3181/00379727-148-38565

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Relationship of Molecular Size of rIn:rCn (Poly I:C) to Induction of Interferon and Host Resistance

Autor: Nemes Mm, Field Ak, Alfred A. Tytell, Maurice R. Hilleman, Lampson Gp

Publikováno v: Experimental Biology and Medicine. 135:911-916

SummaryPreparations of high molecular weight rIn:rCn were exposed to sonic radiation. A decrease in the average molecular weight of the polynucleotide complexes after treatment was accompanied by an exponential decrease in viscosity of the preparatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad6650187ff4098aeba6a995d746b25
https://doi.org/10.3181/00379727-135-35169

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Inducers of Interferon and Host Resistance VI. Antiviral Efficacy of Poly I:C in Animal Models

Autor: Maurice R. Hilleman, Lampson Gp, Alfred A. Tytell, Nemes Mm, Field Ak

Publikováno v: Experimental Biology and Medicine. 132:776-783

SummaryStudies were conducted in mice and chicks to measure the prophylactic and therapeutic efficacy of poly I:C in a variety of infections by both DNA and RNA viruses. Drug and virus were given by a variety of routes in a number of different regime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc5522a90243e38166f87cc362aaaac
https://doi.org/10.3181/00379727-132-34308

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Influence of Polyamines on Induction of Interferon and Resistance to Viruses by Synthetic Polynucleotides

Autor: Maurice R. Hilleman, Lampson Gp, Alfred A. Tytell, Nemes Mm, Field Ak

Publikováno v: Experimental Biology and Medicine. 132:212-218

SummaryCertain basic polyamines, such as neomycin, neamine, kanamycin, streptomycin, and spermine, added to poly I:C increased the Tm. The degree of termal stabilization was influenced by the molecular ratio of polyamine to poly I:C and by the ionic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed51df0592ddc85dbe098cefd8532b4d
https://doi.org/10.3181/00379727-132-34182

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Demonstration of Double-Stranded Ribonucleic Acid in Concentrates of RNA Viruses

Autor: Maurice R. Hilleman, Lampson Gp, Field Ak, Alfred A. Tytell

Publikováno v: Experimental Biology and Medicine. 141:440-444

SummaryNucleic acid preparations from unpurified concentrates of Newcastle disease virus, Sindbis virus and Semliki Forest virus were found to contain up to 2% double-stranded RNA. Double-stranded RNA was identified by reaction with antisera specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97db9d5449c40ce6a4c493c69555ed3
https://doi.org/10.3181/00379727-141-36793

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Antigenicity of Double-Stranded Ribonucleic Acids Including Poly I:C

Autor: Field Ak, Alfred A. Tytell, Maurice R. Hilleman, Lampson Gp

Publikováno v: Experimental Biology and Medicine. 139:1113-1119

SummaryRabbits repeatedly injected intravenously with poly I:C developed antibodies reactive with poly I:C. However, oral or nasal administration of poly I:C to rabbits failed to stimulate detectable circulating antibodies. Intravenous injection of I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3d72bd20fe6452651a26c6864380cd
https://doi.org/10.3181/00379727-139-36310

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