Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Fidzinski, P"'
Autor:
Franz X. Mittermaier, Thilo Kalbhenn, Ran Xu, Julia Onken, Katharina Faust, Thomas Sauvigny, Ulrich W. Thomale, Angela M. Kaindl, Martin Holtkamp, Sabine Grosser, Pawel Fidzinski, Matthias Simon, Henrik Alle, Jörg R. P. Geiger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Synaptic mechanisms that contribute to human memory consolidation remain largely unexplored. Consolidation critically relies on sleep. During slow wave sleep, neurons exhibit characteristic membrane potential oscillations known as UP and DOW
Externí odkaz:
https://doaj.org/article/57a27b36c7d94d5e94272d6236ac910e
Autor:
Ali Rifat, Bernardino Ossola, Roland W. Bürli, Lee A. Dawson, Nicola L. Brice, Anna Rowland, Marina Lizio, Xiao Xu, Keith Page, Pawel Fidzinski, Julia Onken, Martin Holtkamp, Frank L. Heppner, Jörg R. P. Geiger, Christian Madry
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Neuroinflammation is highly influenced by microglia, particularly through activation of the NLRP3 inflammasome and subsequent release of IL-1β. Extracellular ATP is a strong activator of NLRP3 by inducing K+ efflux as a key signaling event,
Externí odkaz:
https://doaj.org/article/208476be51d34f6da4991c7759669750
Akademický článek
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Akademický článek
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Autor:
Alexandra S Agostinho, Mario Mietzsch, Luca Zangrandi, Iwona Kmiec, Anna Mutti, Larissa Kraus, Pawel Fidzinski, Ulf C Schneider, Martin Holtkamp, Regine Heilbronn, Christoph Schwarzer
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-16 (2019)
Abstract Focal epilepsy represents one of the most common chronic CNS diseases. The high incidence of drug resistance, devastating comorbidities, and insufficient responsiveness to surgery pose unmet medical challenges. In the quest of novel, disease
Externí odkaz:
https://doaj.org/article/480489b3db774418b348f8ecb6933d15
Autor:
Sophie Schlabitz, Laura Monni, Alienor Ragot, Matthias Dipper-Wawra, Julia Onken, Martin Holtkamp, Pawel Fidzinski
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Epileptiform activity alters gene expression in the central nervous system, a phenomenon that has been studied extensively in animal models. Here, we asked whether also in vitro models of seizures are in principle suitable to investigate changes in g
Externí odkaz:
https://doaj.org/article/fcdaab168daa48499cd302eadcc4995d
Loss of Long-Term Potentiation at Hippocampal Output Synapses in Experimental Temporal Lobe Epilepsy
Autor:
Sabine Grosser, Nadine Buck, Karl-Heinz Braunewell, Kate E. Gilling, Christian Wozny, Pawel Fidzinski, Joachim Behr
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Patients suffering from temporal lobe epilepsy (TLE) show severe problems in hippocampus dependent memory consolidation. Memory consolidation strongly depends on an intact dialog between the hippocampus and neocortical structures. Deficits in hippoca
Externí odkaz:
https://doaj.org/article/0984827d839d47f8b95f1e1d033d1ce9
Autor:
Larissa Kraus, Florian Hetsch, Ulf C. Schneider, Helena Radbruch, Martin Holtkamp, Jochen C. Meier, Pawel Fidzinski
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy with about 30% of patients developing pharmacoresistance. These patients continue to suffer from seizures despite polytherapy with antiepileptic drugs (AEDs) and have an increased
Externí odkaz:
https://doaj.org/article/dc42ef085b784e66bf52d706199a93a6
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Up to date, preclinical screening for new antiepileptic substances is performed by a combination of different in vivo models of acute seizures, for which large numbers of animals are necessary. So far, little attention has been paid to in vitro model
Externí odkaz:
https://doaj.org/article/b23df167ea944a27b110a4f39380ce38
Akademický článek
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