Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia

Autor: Ali Rifat, Bernardino Ossola, Roland W. Bürli, Lee A. Dawson, Nicola L. Brice, Anna Rowland, Marina Lizio, Xiao Xu, Keith Page, Pawel Fidzinski, Julia Onken, Martin Holtkamp, Frank L. Heppner, Jörg R. P. Geiger, Christian Madry

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)

Abstract Neuroinflammation is highly influenced by microglia, particularly through activation of the NLRP3 inflammasome and subsequent release of IL-1β. Extracellular ATP is a strong activator of NLRP3 by inducing K+ efflux as a key signaling event,

Externí odkaz: https://doaj.org/article/208476be51d34f6da4991c7759669750

Membrane potential states gate synaptic consolidation in human neocortical tissue.

Autor: Mittermaier FX; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neurophysiology, Berlin, Germany., Kalbhenn T; Department of Neurosurgery (Evangelisches Klinikum Bethel), University of Bielefeld Medical Center OWL, Bielefeld, Germany., Xu R; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Onken J; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Faust K; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Sauvigny T; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Thomale UW; Pediatric Neurosurgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Kaindl AM; Department of Pediatric Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Holtkamp M; Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Grosser S; Institute for Integrative Neuroanatomy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Fidzinski P; Neuroscience Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, NeuroCure Cluster of Excellence, Berlin, Germany., Simon M; Department of Neurosurgery (Evangelisches Klinikum Bethel), University of Bielefeld Medical Center OWL, Bielefeld, Germany., Alle H; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neurophysiology, Berlin, Germany., Geiger JRP; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neurophysiology, Berlin, Germany. joerg.geiger@charite.de.

Publikováno v: Nature communications [Nat Commun] 2024 Dec 12; Vol. 15 (1), pp. 10340. Date of Electronic Publication: 2024 Dec 12.

Dynorphin‐based 'release on demand' gene therapy for drug‐resistant temporal lobe epilepsy

Autor: Alexandra S Agostinho, Mario Mietzsch, Luca Zangrandi, Iwona Kmiec, Anna Mutti, Larissa Kraus, Pawel Fidzinski, Ulf C Schneider, Martin Holtkamp, Regine Heilbronn, Christoph Schwarzer

Publikováno v: EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-16 (2019)

Abstract Focal epilepsy represents one of the most common chronic CNS diseases. The high incidence of drug resistance, devastating comorbidities, and insufficient responsiveness to surgery pose unmet medical challenges. In the quest of novel, disease

Externí odkaz: https://doaj.org/article/480489b3db774418b348f8ecb6933d15

Loss of Long-Term Potentiation at Hippocampal Output Synapses in Experimental Temporal Lobe Epilepsy

Autor: Sabine Grosser, Nadine Buck, Karl-Heinz Braunewell, Kate E. Gilling, Christian Wozny, Pawel Fidzinski, Joachim Behr

Publikováno v: Frontiers in Molecular Neuroscience, Vol 13 (2020)

Patients suffering from temporal lobe epilepsy (TLE) show severe problems in hippocampus dependent memory consolidation. Memory consolidation strongly depends on an intact dialog between the hippocampus and neocortical structures. Deficits in hippoca

Externí odkaz: https://doaj.org/article/0984827d839d47f8b95f1e1d033d1ce9

The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs

Autor: Hanno Heuzeroth, Matthias Wawra, Pawel Fidzinski, Ramazan Dag, Martin Holtkamp

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

Up to date, preclinical screening for new antiepileptic substances is performed by a combination of different in vivo models of acute seizures, for which large numbers of animals are necessary. So far, little attention has been paid to in vitro model

Externí odkaz: https://doaj.org/article/b23df167ea944a27b110a4f39380ce38