A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome

Autor: Suhn Kyong Rhie, Andrew A. Perez, Fides D. Lay, Shannon Schreiner, Jiani Shi, Jenevieve Polin, Peggy J. Farnham

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

In prostate cancer, chromatin structure can impact the transcriptome. Here, the authors develop high resolution chromatin interaction maps in prostate cancer cells using in situ Hi-C, revealing prostate cancer-specific TADs and enhancer-promoter loop

Externí odkaz: https://doaj.org/article/bf4333a7da084e70ab3ac3f87cbcc657

A Prostate Cancer Risk Element Functions as a Repressive Loop that Regulates HOXA13

Autor: Peggy J. Farnham, Suhn K. Rhie, Zhifei Luo, Fides D. Lay

Publikováno v: Cell Reports, Vol 21, Iss 6, Pp 1411-1417 (2017)

Summary: Prostate cancer (PCa) is the leading cancer among men in the United States, with genetic factors contributing to ∼42% of the susceptibility to PCa. We analyzed a PCa risk region located at 7p15.2 to gain insight into the mechanisms by whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ebd00c3400fa13d74469d1264359c2
https://doi.org/10.1016/j.celrep.2017.10.048

Cbx3 maintains lineage specificity during neural differentiation

Autor: Robin McKee, Kathrin Plath, Yong Xue, Michael Carey, Chengyang Huang, Fides D. Lay, James A. Wohlschlegel, Meiyang Li, Ajay A. Vashisht, Chen Cheng, Trent Su, Siavash K. Kurdistani, Bennett G. Novitch

Publikováno v: Huang, Chengyang; Su, Trent; Xue, Yong; Cheng, Chen; Lay, Fides D; McKee, Robin A; et al.(2017). Cbx3 maintains lineage specificity during neural differentiation.. Genes & development, 31(3), 241-246. doi: 10.1101/gad.292169.116. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5b39v19j

Chromobox homolog 3 (Cbx3/heterochromatin protein 1γ [HP1γ]) stimulates cell differentiation, but its mechanism is unknown. We found that Cbx3 binds to gene promoters upon differentiation of murine embryonic stem cells (ESCs) to neural progenitor c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22e2ff533cc53192bd38acffe15f0e9
https://doi.org/10.1101/gad.292169.116

Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation

Autor: Peggy J. Farnham, Fides D. Lay, Chris Armoskus, Heather Witt, Benjamin P. Berman, Suhn K. Rhie, Adrian Camarena, Valeria N. Spitsyna, Yu Guo, Shannon Schreiner, James A. Knowles, Oleg V. Evgrafov

Publikováno v: Science Advances

Profiling olfactory neuronal cells from many individuals reveals variations in epigenetic signatures.
As part of PsychENCODE, we developed a three-dimensional (3D) epigenomic map of primary cultured neuronal cells derived from olfactory neuroepi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a699bd0ac7a62c3ada341f10d65b694
https://pubmed.ncbi.nlm.nih.gov/30555922

MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment

Autor: Vincenzo Calvanese, Andrew T. Nguyen, Timothy J. Bolan, Anastasia Vavilina, Trent Su, Lydia K. Lee, Yanling Wang, Fides D. Lay, Mattias Magnusson, Gay M. Crooks, Siavash K. Kurdistani, Hanna K. A. Mikkola

Publikováno v: Nature
Nature, vol 576, iss 7786

Limited knowledge of the mechanisms that govern the self-renewal of human haematopoietic stem cells (HSCs), and why this fails in culture, have impeded the expansion of HSCs for transplantation1. Here we identify MLLT3 (also known as AF9) as a crucia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e898ae27f9a1364d035a6bbd18b99b7d
https://pubmed.ncbi.nlm.nih.gov/31776511