Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Fidel Cai"'
Autor:
Selina Shiqing K. Teh, Kirsten Bowland, Alexis Bennett, Eitan Halper-Stromberg, Alyza Skaist, Aparna Pallavajjala, Jacqueline Tang, Fidel Cai, Antonella Macoretta, Hong Liang, Sarah Wheelan, Ming-Tseh Lin, Ralph H. Hruban, Robert B. Scharpf, Nicholas J. Roberts, James R. Eshleman
Publikováno v:
bioRxiv
Somatic mutations in malignant cells genetically distinguish malignant cells from normal cells. We attempted to determine the type of somatic mutation in cancers that would create the largest number of novel CRISPR-Cas9 target sites. Whole genome seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa413f1c2c6b3e2b399975f964a890e2
https://doi.org/10.1101/2023.04.15.537042
https://doi.org/10.1101/2023.04.15.537042
Autor:
Selina Shiqing K. Teh, Eitan Halper-Stromberg, Laura Morsberger, Alexis Bennett, Kirsten Bowland, Alyza Skaist, Fidel Cai, Hong Liang, Ralph H. Hruban, Nicholas J. Roberts, Robert B. Scharpf, Ying S. Zou, James R. Eshleman
When we transduced pancreatic cancers with sgRNAs that targeted 2-16 target sites in the human genome, we found that increasing the number of CRISPR-Cas9 target sites produced greater cytotoxicity, with >99% growth inhibition observed by targeting on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfce08e6990151926d1c1b26d9d04f01
https://doi.org/10.1101/2023.04.03.535384
https://doi.org/10.1101/2023.04.03.535384