Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Fidan, Seker"'
Autor:
Emily M. Pujadas Liwag, Xiaolong Wei, Nicolas Acosta, Lucas M. Carter, Jiekun Yang, Luay M. Almassalha, Surbhi Jain, Ali Daneshkhah, Suhas S. P. Rao, Fidan Seker-Polat, Kyle L. MacQuarrie, Joe Ibarra, Vasundhara Agrawal, Erez Lieberman Aiden, Masato T. Kanemaki, Vadim Backman, Mazhar Adli
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-42 (2024)
Abstract Background B-type lamins are critical nuclear envelope proteins that interact with the three-dimensional genomic architecture. However, identifying the direct roles of B-lamins on dynamic genome organization has been challenging as their joi
Externí odkaz:
https://doaj.org/article/4305f5fcf633415aacff6d99aeabee41
Autor:
Kadir Buyukcelebi, Alexander J. Duval, Fatih Abdula, Hoda Elkafas, Fidan Seker-Polat, Mazhar Adli
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Uterine fibroids (UF), that can disrupt normal uterine function and cause significant physical and psychological health problems, are observed in nearly 70% of women of reproductive age. Although heritable genetics is a significant risk fact
Externí odkaz:
https://doaj.org/article/cb4cff71b346416789a546546ce12594
Autor:
Ezgi Ozyerli-Goknar, Ezgi Yagmur Kala, Ali Cenk Aksu, Ipek Bulut, Ahmet Cingöz, Sheikh Nizamuddin, Martin Biniossek, Fidan Seker-Polat, Tunc Morova, Can Aztekin, Sonia H. Y. Kung, Hamzah Syed, Nurcan Tuncbag, Mehmet Gönen, Martin Philpott, Adam P. Cribbs, Ceyda Acilan, Nathan A. Lack, Tamer T. Onder, H. T. Marc Timmers, Tugba Bagci-Onder
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Glioblastoma is the most common and aggressive primary brain tumor with extremely poor prognosis, highlighting an urgent need for developing novel treatment options. Identifying epigenetic vulnerabilities of cancer cells can provi
Externí odkaz:
https://doaj.org/article/c47591d07edf46c2af096d40cbb069fd
Autor:
Kadir Buyukcelebi, Xintong Chen, Fatih Abdula, Hoda Elkafas, Alexander James Duval, Harun Ozturk, Fidan Seker-Polat, Qiushi Jin, Ping Yin, Yue Feng, Serdar E. Bulun, Jian Jun Wei, Feng Yue, Mazhar Adli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Nearly 70% of Uterine fibroid (UF) tumors are driven by recurrent MED12 hotspot mutations. Unfortunately, no cellular models could be generated because the mutant cells have lower fitness in 2D culture conditions. To address this, we employ
Externí odkaz:
https://doaj.org/article/f796869116f04aa3836b1d309cad5481
Autor:
Nihal Olcay Dogan, Ugur Bozuyuk, Pelin Erkoc, Alp Can Karacakol, Ahmet Cingoz, Fidan Seker-Polat, Muhammad Anwaar Nazeer, Metin Sitti, Tugba Bagci-Onder, Seda Kizilel
Publikováno v:
Advanced NanoBiomed Research, Vol 2, Iss 1, Pp n/a-n/a (2022)
Experimentation of nanomedicine is labor‐intensive, time‐consuming, and requires costly laboratory consumables. Constructing a reliable mathematical model for such systems is also challenging due to the difficulties in gathering a sufficient numb
Externí odkaz:
https://doaj.org/article/a6dbc2ba15de4ed19bb6da41bc3bf8ab
Drug Repositioning Screen on a New Primary Cell Line Identifies Potent Therapeutics for Glioblastoma
Autor:
Filiz Senbabaoglu, Ali Cenk Aksu, Ahmet Cingoz, Fidan Seker-Polat, Esra Borklu-Yucel, İhsan Solaroglu, Tugba Bagci-Onder
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Glioblastoma is a malignant brain cancer with limited treatment options and high mortality rate. While established glioblastoma cell line models provide valuable information, they ultimately lose most primary characteristics of tumors under long-term
Externí odkaz:
https://doaj.org/article/81515be51a0c4324bb5f19fc51784655
Uterine fibroids (UF), also called leiomyomas, are observed in nearly 70% of women of reproductive age. These tumors disrupt normal uterine function and cause significant physical and psychological health problems. Although heritable genetics is a si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d623f5ef8d10b68b1dfc3836b714a26b
https://doi.org/10.21203/rs.3.rs-2548537/v1
https://doi.org/10.21203/rs.3.rs-2548537/v1
Autor:
Kadir Buyukcelebi, Xintong Chen, Fatih Abdula, Alexander Duval, Harun Ozturk, Fidan Seker-Polat, Qiushi Jin, Ping Yin, Yue Feng, Jian-Jun Wei, Serdar Bulun, Feng Yue, Mazhar Adli
Uterine fibroid (UF) tumors originate from a mutated smooth muscle cell (SMC). Nearly 70% of these tumors are driven by hotspot recurrent somatic mutations in the MED12 gene; however, there are no tractable genetic models to study the biology of UF t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32b45cfbb44aeb215080c69e17dfed95
https://doi.org/10.21203/rs.3.rs-2537075/v1
https://doi.org/10.21203/rs.3.rs-2537075/v1
Autor:
Ezgi Ozyerli-Goknar, Ezgi Yagmur Kala, Ali Cenk Aksu, Ipek Bulut, Ahmet Cingöz, Sheikh Nizamuddin, Martin Biniossek, Fidan Seker-Polat, Tunc Morova, Can Aztekin, Sonia H.A. Kung, Hamzah Syed, Nurcan Tuncbag, Mehmet Gonen, Martin Philpott, Adam P. Cribbs, Ceyda Acilan, Nathan A. Lack, Tamer T. Onder, H.T. Marc Timmers, Tugba Bagci-Onder
Glioblastoma is the most common and aggressive primary brain tumor with poor prognosis, highlighting an urgent need for novel treatment strategies. In this study, we investigated epigenetic regulators of glioblastoma cell survival through CRISPR/Cas9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f032a1c762f5114e54d2d4605bc4daef
https://doi.org/10.1101/2022.08.17.504245
https://doi.org/10.1101/2022.08.17.504245
Autor:
Ahmet Cingoz, Tunc Morova, Zeynep H. Gümüş, Tugba Bagci-Onder, Ihsan Solaroglu, Ezgi Ozyerli-Goknar, Fidan Seker-Polat, Myvizhi Esai Selvan, Deepak Bhere, Khalid Shah
Publikováno v:
Oncogene. 40:3201-3216
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces tumor cell-specific apoptosis, making it a prime therapeutic candidate. However, many tumor cells are either innately TRAIL-resistant, or they acquire resistance with adaptive me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b24d60efb79fffc24cb2ba711c306e40
https://doi.org/10.1038/s41388-021-01697-6
https://doi.org/10.1038/s41388-021-01697-6