Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum

Autor: Wim Annaert, Katleen Dillen, Randy Schekman, Ragna Sannerud, Bertrand Kleizen, Rosanne Wouters, David Demedts, Christine Michiels, Abril Escamilla Ayala, Wendy Vermeire

Publikováno v: Journal of Cell Biology, 220(9), 1. Rockefeller University Press

γ-Secretase affects many physiological processes through targeting >100 substrates; malfunctioning links γ-secretase to cancer and Alzheimer's disease. The spatiotemporal regulation of its stoichiometric assembly remains unresolved. Fractionation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d9039d96590f096bfacb0662aeabdb
https://doi.org/10.1083/jcb.201911104

Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

Autor: D. Proverbio, T. Kralj, Madelon M. Maurice, Piet Gros, Sarah Stryeck, M. Goldflam, C. Ullman, G. Hermans, T. Aastrup, R.C. van Scherpenzeel, T.Z. Bass, Ingrid Jordens, Nicola Fenderico

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications, 10(1), 365. Nature Publishing Group
'Nature Communications ', vol: 10, pages: 365-1-365-13 (2019)

Wnt-induced β-catenin-mediated transcription is a driving force for stem cell self-renewal during adult tissue homeostasis. Enhanced Wnt receptor expression due to mutational inactivation of the ubiquitin ligases RNF43/ZNRF3 recently emerged as a le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76861a7482ab43d1a66ddb22e588929a
https://doaj.org/article/5a4f5bbea0514b429431ef3636e2ef04

Relief of talin autoinhibition triggers a force-independent association with vinculin

Autor: Igor L. Barsukov, Franziska Lausecker, Christoph Ballestrem, Andrew P. Gilmore, David R. Critchley, Alexandre F. Carisey, Paul Atherton

Publikováno v: Atherton, P, Lausecker, F, Carisey, A, Gilmore, A, Critchley, D, Barsukov, I & Ballestrem, C 2020, ' Relief of talin autoinhibition triggers a force-independent association with vinculin ', The Journal of cell biology, vol. 219, no. 1 . https://doi.org/10.1083/jcb.201903134
JOURNAL OF CELL BIOLOGY
The Journal of Cell Biology
Atherton, P, Lausecker, F, Carisey, A, Gilmore, A, Critchley, D, Barsukov, I & Ballestrem, C 2019, ' Relief of talin autoinhibition triggers a force-independent association with vinculin ', The Journal of cell biology, vol. 219, no. 1, e201903134, pp. 1-16 . https://doi.org/10.1083/jcb.201903134

Talin and vinculin control mechanosensing by linking adhesion receptors to the contractile actin cytoskeleton. Using a mitochondrial targeting system, Atherton et al. elucidate mechanisms regulating conformational changes required for vinculin bindin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b9e39aa3f56a04f10d008fdc73da8c
https://www.research.manchester.ac.uk/portal/en/publications/relief-of-talin-autoinhibition-triggers-a-forceindependent-association-with-vinculin(bb6e044b-4af7-4453-ae9a-c09b2c22400e).html

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis

Autor: Lise Secardin, William Vainchenker, Olivier Bernard, Alexander A. Ishchenko, Murat Saparbaev, Emna Mahfoudhi, Philippe Rameau, Véronique Della Valle, Ibtissam Talhaoui, Isabelle Plo, Xenia Cabagnols, Salem Abbes

Publikováno v: DNA Repair
DNA Repair, Elsevier, 2016, 43, pp.78-88. <10.1016/j.dnarep.2016.05.031>
DNA Repair, Elsevier, 2016, 43, pp.78-88. ⟨10.1016/j.dnarep.2016.05.031⟩
DNA Repair, 2016, 43, pp.78-88. ⟨10.1016/j.dnarep.2016.05.031⟩

International audience; The family of Ten-Eleven Translocation (TET) proteins is implicated in the process of active DNA demethy-lation and thus in epigenetic regulation. TET 1, 2 and 3 proteins are oxygenases that can hydroxylate 5-methylcytosine (5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62d059a77d68707fe91ef4741f2a19f
https://doi.org/10.1016/j.dnarep.2016.05.031

Stem cell dynamics, migration and plasticity during wound healing

Autor: Cédric Blanpain, Sophie Dekoninck

Publikováno v: Nature cell biology, 21 (1

Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem cells recruited from various skin regions together with other ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3301ee78f3c6ab17e923ffd82960138c
https://pubmed.ncbi.nlm.nih.gov/30602767