Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Fibroblasts/metabolism"'
Autor:
Dimitra Papadopoulou, Fani Roumelioti, Christos Tzaferis, Panagiotis Chouvardas, Anna-Kathrine Pedersen, Filippos Charalampous, Eleni Christodoulou-Vafeiadou, Lydia Ntari, Niki Karagianni, Maria C. Denis, Jesper V. Olsen, Alexios N. Matralis, George Kollias
Publikováno v:
Papadopoulou, D, Roumelioti, F, Tzaferis, C, Chouvardas, P, Pedersen, A-K, Charalampous, F, Christodoulou-Vafeiadou, E, Ntari, L, Karagianni, N, Denis, M C, Olsen, J V, Matralis, A N & Kollias, G 2023, ' Repurposing the antipsychotic drug amisulpride for targeting synovial fibroblast activation in arthritis ', JCI insight, vol. 8, no. 9, e165024 . https://doi.org/10.1172/jci.insight.165024
Synovial fibroblasts (SFs) are key pathogenic drivers in rheumatoid arthritis (RA). Their in vivo activation by TNF is sufficient to orchestrate full arthritic pathogenesis in animal models, and TNF blockade proved efficacious for a high percentage o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4e599266cb2031c1ac782736bbc371
https://doi.org/10.1172/jci.insight.165024
https://doi.org/10.1172/jci.insight.165024
Autor:
Lidia H. Pulz, Yonara G. Cordeiro, Greice C. Huete, Karine G. Cadrobbi, Arina L. Rochetti, Pedro L. P. Xavier, Adriana Tomoko Nishiya, Silvio Henrique de Freitas, Heidge Fukumasu, Ricardo F. Strefezzi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Pulz, L H, Cordeiro, Y G, Huete, G C, Cadrobbi, K G, Rochetti, A L, Xavier, P L P, Nishiya, A T, de Freitas, S H, Fukumasu, H & Strefezzi, R F 2021, ' Intercellular interactions between mast cells and stromal fibroblasts obtained from canine cutaneous mast cell tumours ', Scientific Reports, vol. 11, no. 1, 23881 . https://doi.org/10.1038/s41598-021-03390-w
Scientific Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Pulz, L H, Cordeiro, Y G, Huete, G C, Cadrobbi, K G, Rochetti, A L, Xavier, P L P, Nishiya, A T, de Freitas, S H, Fukumasu, H & Strefezzi, R F 2021, ' Intercellular interactions between mast cells and stromal fibroblasts obtained from canine cutaneous mast cell tumours ', Scientific Reports, vol. 11, no. 1, 23881 . https://doi.org/10.1038/s41598-021-03390-w
Scientific Reports
Mast cell tumours (MCTs) are the most frequent malignant skin neoplasm in dogs. Due to the difficulty in purifying large numbers of canine neoplastic mast cells, relatively little is known about their properties. A reproducible in vitro model is need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be14cf2e94e56b2d8f49bc044e49497a
https://doaj.org/article/7232bd8e834947de85de5505c2daee64
https://doaj.org/article/7232bd8e834947de85de5505c2daee64
Autor:
Wenxia Wang, Swarna Bale, Jun Wei, Bharath Yalavarthi, Dibyendu Bhattacharyya, Jing Jing Yan, Hiam Abdala-Valencia, Dan Xu, Hanshi Sun, Roberta G. Marangoni, Erica Herzog, Sergejs Berdnikovs, Stephen D. Miller, Amr H. Sawalha, Pei-Suen Tsou, Kentaro Awaji, Takashi Yamashita, Shinichi Sato, Yoshihide Asano, Chinnaswamy Tiruppathi, Anjana Yeldandi, Bettina C. Schock, Swati Bhattacharyya, John Varga
Publikováno v:
Wang, W, Bale, S, Wei, J, Yalavarthi, B, Bhattacharyya, D, Yan, J J, Abdala-Valencia, H, Xu, D, Sun, H, Marangoni, R G, Herzog, E, Berdnikovs, S, Miller, S D, Sawalha, A H, Tsou, P-S, Awaji, K, Yamashita, T, Sato, S, Asano, Y, Tiruppathi, C, Yeldandi, A, Schock, B C, Bhattacharyya, S & Varga, J 2022, ' Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs ', Nature Communications, vol. 13, 6358 . https://doi.org/10.1038/s41467-022-33767-y
In addition to autoimmune and inflammatory diseases, variants of the TNFAIP3 gene encoding the ubiquitin-editing enzyme A20 are also associated with fibrosis in systemic sclerosis (SSc). However, it remains unclear how genetic factors contribute to S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a338b12062d469a0db07176e067af3
https://pure.qub.ac.uk/en/publications/8b36a497-37c9-40f4-b01a-2423feab81db
https://pure.qub.ac.uk/en/publications/8b36a497-37c9-40f4-b01a-2423feab81db
Autor:
Laura, Yerly, Christine, Pich-Bavastro, Jeremy, Di Domizio, Tania, Wyss, Stéphanie, Tissot-Renaud, Michael, Cangkrama, Michel, Gilliet, Sabine, Werner, François, Kuonen
Publikováno v:
Nature Communications, 13 (1)
Nature communications, vol. 13, no. 1, pp. 4897
Nature communications, vol. 13, no. 1, pp. 4897
Tumors invade the surrounding tissues to progress, but the heterogeneity of cell types at the tumor-stroma interface and the complexity of their potential interactions hampered mechanistic insight required for efficient therapeutic targeting. Here, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724d652487aa890b7e8fe942f98946b3
https://doi.org/10.26226/m.63185c4d7e215f5e7f3850cc
https://doi.org/10.26226/m.63185c4d7e215f5e7f3850cc
Autor:
Nataly Puerta Cavanzo, Sophie A. Riesmeijer, Iris L. Holt-Kedde, Paul M. N. Werker, Bram Piersma, Peter Olinga, Ruud A. Bank
Publikováno v:
Scientific Reports, 12(1):13940. Nature Publishing Group
Dupuytren’s disease is a chronic, progressive fibroproliferative condition of the hand fascia which results in digital contraction. So far, treatments do not directly interfere with the (myo)fibroblasts that are responsible for the formation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69b33ff2348ac13743ba2718e8355d1
https://research.rug.nl/en/publications/9f10b3e6-86c4-4448-9468-79e5d380f8f4
https://research.rug.nl/en/publications/9f10b3e6-86c4-4448-9468-79e5d380f8f4
Autor:
Jo Van Ginderachter
Publikováno v:
Cancer Research. 82:3882-3883
Immunotherapy of cancer is a burgeoning field of research since the realization that our immune system intrinsically has the capacity to restrict tumor occurrence and progression. Though strategies to maximize antitumor T-cell activation are well est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a44f2573261107417022e5c7dbba202
https://doi.org/10.1158/0008-5472.can-22-2774
https://doi.org/10.1158/0008-5472.can-22-2774
Autor:
Laura Capolupo, Irina Khven, Alex R. Lederer, Luigi Mazzeo, Galina Glousker, Sylvia Ho, Francesco Russo, Jonathan Paz Montoya, Dhaka R. Bhandari, Andrew P. Bowman, Shane R. Ellis, Romain Guiet, Olivier Burri, Johanna Detzner, Johannes Muthing, Krisztian Homicsko, François Kuonen, Michel Gilliet, Bernhard Spengler, Ron M. A. Heeren, G. Paolo Dotto, Gioele La Manno, Giovanni D’Angelo
Publikováno v:
Science, 376(6590):eabh1623. American Association for the Advancement of Science
Human cells produce thousands of lipids that change during cell differentiation and can vary across individual cells of the same type. However, we are only starting to characterize the function of these cell-to-cell differences in lipid composition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110e0c2c2d1411b0740884ffa8b0473d
https://doi.org/10.1126/science.abh1623
https://doi.org/10.1126/science.abh1623
Publikováno v:
Seminars in Cancer Biology
Seminars in cancer biology, 62
Seminars in cancer biology, 62
The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM) macromolecules filled with a collection of cells including cancer-associated fibroblasts (CAFs), blood vessel associated smooth muscle cells, pericytes, endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baaa1409d6eb1ab3f3b6133f9a7a5a00
https://doi.org/10.1016/j.semcancer.2019.08.004
https://doi.org/10.1016/j.semcancer.2019.08.004
Autor:
Dennis E. M. de Bakker, Esther Dronkers, Mara Bouwman, Filipa C. Simões, Jeroen Bakkers, Anke M. Smits, Marie-José Goumans, Paul R. Riley
Publikováno v:
Development (Cambridge), 148(19). Company of Biologists Ltd
Development (Cambridge, England)
article-version (VoR) Version of Record
DEVELOPMENT, 148(19). The Company of Biologists
Development (Cambridge, England)
article-version (VoR) Version of Record
DEVELOPMENT, 148(19). The Company of Biologists
Fibroblasts are activated to repair the heart following injury. Fibroblast activation in the mammalian heart leads to a permanent fibrotic scar that impairs cardiac function. In other organisms, such as zebrafish, cardiac injury is followed by transi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c333f021807b5558bf89247fe25b3e46
https://doi.org/10.1242/dev.198937
https://doi.org/10.1242/dev.198937
Autor:
Angelika Rieß, Shabab B. Hannan, Hessa S. Alsaif, Tadahiro Mitani, Ghassan Balousha, Siddharth Banka, Kendall C. Parks, Reza Azizi Malamiri, Henry Houlden, James R. Lupski, Elliott H. Sherr, Emanuela Argilli, Joseph J. Gleeson, Osama Balousha, Jakob Admard, Thomas Nägele, Adam Jackson, Zaid Ghanim, Alistair T. Pagnamenta, Ana Velic, Sarah Dyack, Reza Maroofian, Holger Hengel, Hamad Al-Zaidan, Stefanie Schuster, Amber Begtrup, Neda Mazaheri, Helen Kingston, Stephan Ossowski, Davut Pehlivan, Ludger Schöls, Mohammad Yahya Vahidi Mehrjardi, Stefan Hauser, Tobias B. Haack, Sara MacKay, Gholamreza Shariati, Hamid Galehdari, Mathew Osmond, Nicolas Casadei, Martin Fleger, Sevcan Tug Bozdogan, Andreas Kurringer, Ulrich A. Schatz, Boris Macek, Fowzan S. Alkuraya, Mohammadreza Dehghani
Publikováno v:
American journal of human genetics, vol 108, iss 6
The American journal of human genetics 108(6), 1069-1082 (2021). doi:10.1016/j.ajhg.2021.04.024
American Journal of Human Genetics
Care4Rare Canada Consortium 2021, ' Bi-allelic loss-of-function variants in BCAS3 cause a syndromic neurodevelopmental disorder ', American Journal of Human Genetics, vol. 108, no. 6, pp. 1069-1082 . https://doi.org/10.1016/j.ajhg.2021.04.024
The American journal of human genetics 108(6), 1069-1082 (2021). doi:10.1016/j.ajhg.2021.04.024
American Journal of Human Genetics
Care4Rare Canada Consortium 2021, ' Bi-allelic loss-of-function variants in BCAS3 cause a syndromic neurodevelopmental disorder ', American Journal of Human Genetics, vol. 108, no. 6, pp. 1069-1082 . https://doi.org/10.1016/j.ajhg.2021.04.024
Summary BCAS3 microtubule-associated cell migration factor (BCAS3) is a large, highly conserved cytoskeletal protein previously proposed to be critical in angiogenesis and implicated in human embryogenesis and tumorigenesis. Here, we established BCAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b3a8a3a40ba3c0e4b68246c46199e4
https://escholarship.org/uc/item/7rn0f207
https://escholarship.org/uc/item/7rn0f207