Zobrazeno 1 - 10
of 12 061
pro vyhledávání: '"Fibroblast growth factor receptor"'
Autor:
Anas Shamsi, Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Mohammad Furkan, Rizwan Hasan Khan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Developing new therapeutic strategies to target specific molecular pathways has become a primary focus in modern drug discovery science. Fibroblast growth factor receptor 2 (FGFR2) is a critical signaling protein involved in various cellular
Externí odkaz:
https://doaj.org/article/949016c0b9af465587dfc868099a92e8
Autor:
Dereje E. Bogale
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Bladder cancer is one of the most frequently occurring cancers worldwide. At diagnosis, 75% of urothelial bladder cancer cases have non-muscle invasive bladder cancer while 25% have muscle invasive or metastatic disease. Aberrantly activated
Externí odkaz:
https://doaj.org/article/0f39e133ecfe4951bd109a6ff367534c
Publikováno v:
Nigerian Journal of Paediatrics, Vol 47, Iss 3, Pp 277-279 (2024)
Thanatophoric dysplasia is a lethal form of skeletal dysplasia seen in neonates. The word ‘thanatophoric’ is derived from the Greek word thanatophorus meaning death bringing. Thanatophoric dysplasia results from mutations within the Fibroblast Gr
Externí odkaz:
https://doaj.org/article/0900439d31244af7a8f4d8c633319805
Publikováno v:
Animal Cells and Systems, Vol 28, Iss 1, Pp 216-227 (2024)
ABSTRACTTyrosine kinase inhibitors (TKIs) have emerged as a potential treatment strategy for glioblastoma multiforme (GBM). However, their efficacy is limited by various drug resistance mechanisms. To devise more effective treatments for GBM, genetic
Externí odkaz:
https://doaj.org/article/26d79f4d4ab7426ab2628d192cc2c124
Autor:
Heng-Zhen Li, Jing-lve Zhang, Dong-Liang Yuan, Wen-Qing Xie, Christoph H. Ladel, Ali Mobasheri, Yu-Sheng Li
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-23 (2024)
Abstract Fibroblast growth factor (FGF) signaling encompasses a multitude of functions, including regulation of cell proliferation, differentiation, morphogenesis, and patterning. FGFs and their receptors (FGFR) are crucial for adult tissue repair pr
Externí odkaz:
https://doaj.org/article/4ceb09a5a6724476871ca3feebd558f8
Publikováno v:
Endocrine Journal, Vol 71, Iss 7, Pp 643-650 (2024)
Achondroplasia (ACH) is a representative skeletal disorder characterized by rhizomelic shortened limbs and short stature. ACH is classified as belonging to the fibroblast growth factor receptor 3 (FGFR3) group. The downstream signal transduction of F
Externí odkaz:
https://doaj.org/article/f10d452caa274538b4c80158bd60eb0d
Autor:
Issahy Cano, Melissa Wild, Urvi Gupta, Suman Chaudhary, Yin Shan Eric Ng, Magali Saint-Geniez, Patricia A. D’Amore, Zhengping Hu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract The endothelial glycocalyx, located at the luminal surface of the endothelium, plays an important role in the regulation of leukocyte adhesion, vascular permeability, and vascular homeostasis. Endomucin (EMCN), a component of the endothelial
Externí odkaz:
https://doaj.org/article/f866f4dfaaaf46d7b2fa5d0f1a92f343
Autor:
Zhifeng Huang, Tongtong Pan, Liang Xu, Lu Shi, Xiong Ma, Liya Zhou, Luyao Wang, Jiaojiao Wang, Guoqing Zhu, Dazhi Chen, Lingtao Song, Xiaomin Pan, Xiaodong Wang, Xiaokun Li, Yongde Luo, Yongping Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 4, Pp 1605-1623 (2024)
Immune-mediated liver injury (ILI) is a condition where an aberrant immune response due to various triggers causes the destruction of hepatocytes. Fibroblast growth factor 4 (FGF4) was recently identified as a hepatoprotective cytokine; however, its
Externí odkaz:
https://doaj.org/article/5756349c51df4eb880a69f903e1fcdd2
Publikováno v:
Zhongguo linchuang yanjiu, Vol 37, Iss 2, Pp 192-196 (2024)
The incidence and mortality of gastric cancer are in the forefront of the tumor, and the prognosis is poor, especially in the middle and advanced stage. Even with comprehensive treatment, the 5- year survival is very low. The development of precision
Externí odkaz:
https://doaj.org/article/065a6de60deb46f59ec1c4a820d2cf70
Autor:
I. Tsimafeyeu, P. Makhov, D. Ovcharenko, J. Smith, Y. Khochenkova, A. Olshanskaya, D. Khochenkov
Publikováno v:
Immuno-Oncology and Technology, Vol 23, Iss , Pp 100725- (2024)
Background: Fibroblast growth factor receptor 1 (FGFR1) plays a crucial role in carcinogenesis. Exploring the combination of the novel humanized monoclonal anti-FGFR1 antibody OM-RCA-01 and immunotherapy was intriguing due to involvement of FGFR1 in
Externí odkaz:
https://doaj.org/article/43c022b902de482aa5ac5965b28157dd