Výsledky vyhledávání - "Fibrinolysis/drug effects"

Enterococcus faecalis exploits the human fibrinolytic system to drive excess collagenolysis: implications in gut healing and identification of druggable targets

Autor: Benjamin D. Shogan, Richard A. Jacobson, Sanjiv Hyoju, Alexander Zaborin, Kiedo Wienholts, Olga Zaborina, Ashley J. Williamson, Sara Gaines, Harry van Goor, John C. Alverdy

Publikováno v: Jacobson, R A, Wienholts, K, Williamson, A J, Gaines, S, Hyoju, S, van Goor, H, Zaborin, A, Shogan, B D, Zaborina, O & Alverdy, J C 2020, ' Enterococcus faecalis exploits the human fibrinolytic system to drive excess collagenolysis : Implications in gut healing and identification of druggable targets ', American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 318, no. 1, pp. G1-G9 . https://doi.org/10.1152/AJPGI.00236.2019
American Journal of Physiology : Gastrointestinal and Liver Physiology, 318, G1-G9
American Journal of Physiology-Gastrointestinal and Liver Physiology, 318(1), G1-G9. American Physiological Society
American journal of physiology. Gastrointestinal and liver physiology, 318(1), G1-G9. American Physiological Society
Am J Physiol Gastrointest Liver Physiol
American Journal of Physiology : Gastrointestinal and Liver Physiology, 318, 1, pp. G1-G9

Perforations, anastomotic leak, and subsequent intra-abdominal sepsis are among the most common and feared complications of invasive interventions in the colon and remaining intestinal tract. During physiological healing, tissue protease activity is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3827b2013fda76b3b7ed5bcf13671f
https://doi.org/10.1152/ajpgi.00236.2019

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Fibrin clot structure - pro-fibrinolytic effect of oral contraceptives in apparently healthy women

Autor: Ulrich Winkler, Johannes Jakobsen Sidelmann, Andrea H. Krug, Jørgen Jespersen, Jørgen Gram, Cornelis Kluft

Publikováno v: Sidelmann, J J, Kluft, C, Krug, A H, Winkler, U, Jespersen, J & Gram, J B 2017, ' Fibrin clot structure-pro-fibrinolytic effect of oral contraceptives in apparently healthy women ', Thrombosis and Haemostasis, vol. 117, no. 4, pp. 700-705 . https://doi.org/10.1160/TH16-10-0748

SummaryFibrin metabolism is influenced by many factors. The velocity of fibrin formation, genetic polymorphisms, fibrinolytic features and the structure of the fibrin clot are determinants of fibrin turnover. Oral contraceptives (OCs) have significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6968af83130bc95076779ab188fdf54
https://pubmed.ncbi.nlm.nih.gov/28150855

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Thromboelastometry (TEM) findings in disseminated intravascular coagulation in a pig model of endotoxinemia

Autor: Heinz Redl, Arthur Schulz, Cristina Solomon, Herbert Schöchl, Martijn van Griensven, Alexander A. Hanke, Wolfgang G. Voelckel, Soheyl Bahrami

Publikováno v: Molecular Medicine. 17(3-4):266-72

Standard coagulation tests have a low specificity and sensitivity for diagnosing disseminated intravascular coagulation. The aim of this study was to determine whether whole blood thromboelastometry (TEM) detects lipopolysaccharide (LPS)-induced chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e8135f46f146b9bdcc6edeb02313ac
https://doi.org/10.2119/molmed.2010.00159

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Lysability of fibrin clots is a potential new determinant of stroke risk in atrial fibrillation

Autor: Jane Skov, Johannes Jakobsen Sidelmann, Jørgen Gram, Jørgen Jespersen, Else-Marie Bladbjerg

Publikováno v: Skov, J, Sidelmann, J J, Bladbjerg, E-M, Jespersen, J & Gram, J B 2014, ' Lysability of fibrin clots is a potential new determinant of stroke risk in atrial fibrillation ', Thrombosis Research, vol. 134, no. 3, pp. 717-722 . https://doi.org/10.1016/j.thromres.2014.06.031

MATERIALS AND METHODS: A total of 179 patients with atrial fibrillation in stable anticoagulant treatment were included. Thirty-two had a previous ischemic stroke. We measured thrombin generation, plasma concentrations of fibrinogen and C-reactive pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95d1c377c566c6234661e8813574a77
https://pubmed.ncbi.nlm.nih.gov/25042725

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Elektronická kniha

Synthetic Substrates in Clinical Blood Coagulation Assays

Autor: H.R. Lijnen

This book contains the proceedings of a symposium on the use of synthetic substrates in clinical blood coagulation assays, which was held at the University of Leuven, Belgium, on March 1st, 1980. This meeting was organized in order to exchange and di

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Effect of DDAVP on Endotoxin-Induced Intravascular Coagulation in Rabbits

Autor: M.J. Paloma, Eduardo Rocha, José A. Páramo

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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SummaryWe have evaluated the effect of l-Deamino-8D-arginine vasopressin (DDAVP) on an experimental model of intravascular coagulation (DIC) induced in rabbits by injection of 20 µg kg–1 h–1 during 6 h of E. coli lipopolysaccharide. DDAVP signif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec97842b6cf3537753d809a76cd69f9
https://doi.org/10.1055/s-0038-1656370

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In vivo clot lysis of human thrombus with intravenous abciximab immunobubbles and ultrasound

Autor: Mark Stroick, Angelika Alonso, Eric Allémann, Michael G. Hennerici, Katrin Zohsel, Alberto Della Martina, Marc Fatar, Carl-Erik Dempfle, Stephen Meairs

Publikováno v: Thrombosis Research, Vol. 124, No 1 (2009) pp. 70-74

Abciximab immunobubbles have been introduced recently for ultrasonographic molecular imaging of human thrombus. This study investigates the potential of using these novel bubbles for enhancing sonothrombolysis. In particular, it addresses the questio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b217e18eaed314f2d6c5968edb7fac
https://pubmed.ncbi.nlm.nih.gov/19349068

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Effect of barnidipine on blood pressure and serum metabolic parameters in patients with essential hypertension: a pilot study

Autor: Spirou, A., Rizos, E., Liberopoulos, E. N., Kolaitis, N., Achimastos, A., Tselepis, A. D., Elisaf, M. S.

The effect of barnidipine, a calcium channel blocker, on metabolic parameters is not well known. The authors conducted the present pilot study to evaluate the possible effects of barnidipine on parameters involved in atherogenesis, oxidative stress,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::a4a477cf231d2c3fa01d74c650eb9da0
http://olympias.lib.uoi.gr/jspui/handle/123456789/22235

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Reducción de los requerimientos de hemoderivados en el trasplante hepático con aprotinina

Autor: Monedero, P. (Pablo), Paramo, J.A. (José Antonio), Carrascosa, F. (Francisco), Herrero, J.I. (José Ignacio), Hidalgo, F. (Francisco), Iribarren, M.J. (M. J.), Garcia-Pedrajas, F. (F.)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Prophylactic use of aprotinin during surgery has a beneficial effect on hemostatic mechanisms, reducing the need for blood products. A reduction in fibrinolysis seems to contribute to this effect.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c9ae7c3ff960976b6f2cb548fdd60d5a
https://hdl.handle.net/10171/29257

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