Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration

Autor: Andrea Armirotti, Debora Russo, Andrea Nuzzi, Paolo Di Fruscia, Daniela Pizzirani, Chiara Pagliuca, Giovanni Bottegoni, Annalisa Fiasella, Ilaria Penna, Jose Antonio Ortega, Elisa Romeo, Francesca Giacomina, Sine Mandrup Bertozzi, Angelo Reggiani, Maria Summa, Anna Carbone, Roberta Giampà, Rosalia Bertorelli, Francesco Berti, Tiziano Bandiera, Luisa Mengatto, Stefano Ponzano, Glauco Tarozzo, Fabio Bertozzi

Publikováno v: Journal of Medicinal Chemistry

Inhibition of intracellular N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity is a promising approach to manage the inflammatory response under disabling conditions. In fact, NAAA inhibition preserves endogenous palmitoylethanolamide (PEA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25d6abb364b90e4db233d64f4ecf7b3
https://doi.org/10.1021/acs.jmedchem.1c00575

Idiopathic Pulmonary Lymphoid Diffuse Hyperplasia

Autor: P.A. Canessa, L. Pratticò, F. Fiasella, A. Cavazza, B. Bacigalupo, F. Fedeli

Publikováno v: Monaldi Archives for Chest Disease, Vol 71, Iss 2 (2016)

We describe a 70 year old woman affected by diffuse pulmonary lymphoid hyperplasia (DPLH). DPLH is a rare clinical-pathological entity generally associated with connective tissue diseases, but we diagnosed our case as an idiopathic DPLH. To the best

Externí odkaz: https://doaj.org/article/477d6446898d4b9dbffbd53161ea3e7f

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Association between Satisfaction with Dialysis Treatment and Quality of Life: A Cross-Sectional Study

Autor: Matteo Pernazza, Pietro Dattolo, Alessandro Toccafondi, Luigi Cirillo, Roberta Cutruzzulà, Alessandra Miraglia Raineri, Susanna Fiasella

Publikováno v: Blood purification. 50(2)

Introduction: CKD is associated with a reduction of patients’ health-related quality of life. Considering the time spent in dialysis, satisfaction with care is essential for patients QOL. Objective: Since the possible association between satisfacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d52242a614ff45da41a8385afe4f6d
https://pubmed.ncbi.nlm.nih.gov/32846414

An Important Role for N-Acylethanolamine Acid Amidase in the Complete Freunds Adjuvant Rat Model of Arthritis

Autor: Fabiola Bonezzi, Oscar Sasso, Silvia Pontis, Natalia Realini, Fabio Bertozzi, Daniele Piomelli, Stefano Ponzano, Andrea Nuzzi, Annalisa Fiasella, Elisa Romeo

Publikováno v: Bonezzi, FT; Sasso, O; Pontis, S; Realini, N; Romeo, E; Ponzano, S; et al.(2016). An Important Role for N-Acylethanolamine Acid Amidase in the Complete Freund's Adjuvant Rat Model of Arthritis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 356(3), 656-663. doi: 10.1124/jpet.115.230516. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9f1335w5

The endogenous lipid amides, palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), exert marked antinociceptive and anti-inflammatory effects in animal models by engaging nuclear peroxisome proliferator-activated receptor-α. PEA and OEA are prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74873a3af9c373b4f663ee47e81d99f8
https://doi.org/10.1124/jpet.115.230516