Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Fiach C. O'Mahony"'
Autor:
Alexander L. R. Lubbock, Grant D. Stewart, Fiach C. O’Mahony, Alexander Laird, Peter Mullen, Marie O’Donnell, Thomas Powles, David J. Harrison, Ian M. Overton
Publikováno v:
BMC Medicine, Vol 15, Iss 1, Pp 1-12 (2017)
Abstract Background Metastatic clear cell renal cell cancer (mccRCC) portends a poor prognosis and urgently requires better clinical tools for prognostication as well as for prediction of response to treatment. Considerable investment in molecular ri
Externí odkaz:
https://doaj.org/article/aa90bc574f0f41a1b1be9cae25200d23
Autor:
Rafia S. Al-Lamki, Nicholas J. Hudson, John R. Bradley, Anne Y. Warren, Tim Eisen, Sarah J. Welsh, Antony C. P. Riddick, Fiach C. O’Mahony, Arran Turnbull, Thomas Powles, SCOTRRCC Collaborative, Antonio Reverter, David J. Harrison, Grant D. Stewart
Publikováno v:
Biology, Vol 9, Iss 4, p 74 (2020)
Anti-angiogenic agents, such as the multi-tyrosine kinase inhibitor sunitinib, are key first line therapies for metastatic clear cell renal cell carcinoma (ccRCC), but their mechanism of action is not fully understood. Here, we take steps towards val
Externí odkaz:
https://doaj.org/article/bdec240a0b9e42e0af0a9f88f0e82598
Autor:
Thomas Powles, David J. Harrison, Ian M. Overton, Michael Aitchison, Axel Bex, Daniel Berney, Antony C.P. Riddick, S. Alan McNeill, Peter Mullen, Marie O'Donnell, Jyoti Nanda, Alan Mackay, Alexander L.R. Lubbock, Lel Eory, Alexander Laird, Fiach C. O'Mahony, Grant D. Stewart
Purpose: The aim of this study was to investigate the effect of VEGF-targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC).Experimental Design: Multiple tumor samples (n = 187 sample
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738a2f7a83396a6b73601baba6b814bd
https://doi.org/10.1158/1078-0432.c.6523416
https://doi.org/10.1158/1078-0432.c.6523416
Autor:
Thomas Powles, David J. Harrison, Ian M. Overton, Michael Aitchison, Axel Bex, Daniel Berney, Antony C.P. Riddick, S. Alan McNeill, Peter Mullen, Marie O'Donnell, Jyoti Nanda, Alan Mackay, Alexander L.R. Lubbock, Lel Eory, Alexander Laird, Fiach C. O'Mahony, Grant D. Stewart
Supplementary Figures 1-2, Supplementary Tables 1-2. Fig. S1. Histogram showing lack of correlation between differential protein and RNA expression levels between sunitinib naive and treated patient samples; Figure S2: Dendrograms illustrating superv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129c6bfacb49741bef08bee8ccb39e15
https://doi.org/10.1158/1078-0432.22456785
https://doi.org/10.1158/1078-0432.22456785
Autor:
Alexander Laird, Fiach C O'Mahony, Jyoti Nanda, Antony C P Riddick, Marie O'Donnell, David J Harrison, Grant D Stewart
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60483 (2013)
Renal cell carcinoma (RCC) is the most deadly of urological malignancies. Metastatic disease affects one third of patients at diagnosis with a further third developing metastatic disease after extirpative surgery. Heterogeneity in the clinical course
Externí odkaz:
https://doaj.org/article/a7361a2fec1345fa971f95bf8789058f
Autor:
Alison Ramsey, Duncan McLaren, Robert Nairn, Kevin M. O'Connor, Gavin W.A. Lamb, Jane Hair, Alexander Laird, Brian Little, Ian Dunn, David J. Harrison, S. Alan McNeill, Roderick Campbell, Liza McLornan, Antony C. P. Riddick, Maeve A. Rahilly, Paul Fineron, Craig Marshall, Michael Aitchison, Steve Leung, Marie O'Donnell, Linda MacLeod, Anne-Marie Pollock, Morag Seywright, Frances Rae, Grant D. Stewart, Ian Wilson, Fiach C. O'Mahony, Torquil Macleod, Grenville Oades
Publikováno v:
The Surgeon. 13:181-186
Background High quality human biosamples with associated high quality clinical data are essential for successful translational research. Despite this, the traditional approach is for the surgeon to act as a technician in the tissue collection act. Bi
Autor:
Alexander Laird, Thomas Powles, Tim De Meyer, Wim Van Criekinge, Grant D. Stewart, David J. Harrison, Filip Van Nieuwerburgh, Christophe Van Neste, Fiach C. O'Mahony, Dieter Deforce
This work was supported by the Chief Scientist Office, Scotland (ETM37; GDS, DJH), Cancer Research UK (Experimental Cancer Medicine Centre; TP, London, DJH, Edinburgh), Medical Research Council (AL, DJH), Royal College of Surgeons of Edinburgh Robert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7185a77f2fcd66d0ae8909b59a16a503
https://hdl.handle.net/10023/12459
https://hdl.handle.net/10023/12459
Autor:
Alexander L R, Lubbock, Grant D, Stewart, Fiach C, O'Mahony, Alexander, Laird, Peter, Mullen, Marie, O'Donnell, Thomas, Powles, David J, Harrison, Ian M, Overton
Publikováno v:
BMC Medicine
Background Metastatic clear cell renal cell cancer (mccRCC) portends a poor prognosis and urgently requires better clinical tools for prognostication as well as for prediction of response to treatment. Considerable investment in molecular risk strati
Publikováno v:
Analytical Letters. 43:1746-1755
A screening assay for the measurement of activity and inhibition of cholinesterase enzymes is described. It employs a coupled bi-enzymatic reaction of butyrylcholinesterase and choline oxidase and quenched-phosphorescence detection of dissolved oxyge
Publikováno v:
Food Control. 20:129-135
A simple test for determining total aerobic viable counts in raw meat is presented. Homogenates of meat samples are prepared in full PBW medium, dispensed in the wells of 96-well plate together with the oxygen-sensing probe, Redlight, covered with oi