Zobrazeno 1 - 10
of 2 577
pro vyhledávání: '"Fgfr2"'
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-7 (2024)
Abstract Combined hepatocellular-cholangiocarcinoma (cHCC-CCA), an extremely rare and underinvestigated subtype of primary liver cancer in children, generally has a poor prognosis and greater aggressiveness. Histological diagnosis of cHCC-CCA is diff
Externí odkaz:
https://doaj.org/article/db2b96e8b9a54b658dbab57ff3bd651d
Autor:
Yue Li, Du He, Zi-Jian Lu, Xia-Fei Gu, Xiao-Yu Liu, Min Chen, Yin-Xia Tu, Yu Zhou, Gemma Owen, Xian Zhang, Dan Jiang
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract There is limited research on the clinicopathological characteristics of combined hepatocellular-cholangiocarcinoma (cHCC-CCA) currently. The aim of this study is to summerize the clinicopathological factors and prognosis of cHCC-CCA, which c
Externí odkaz:
https://doaj.org/article/825a203b36ef429ba31d59d46ad8fce3
Autor:
Anas Shamsi, Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Mohammad Furkan, Rizwan Hasan Khan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Developing new therapeutic strategies to target specific molecular pathways has become a primary focus in modern drug discovery science. Fibroblast growth factor receptor 2 (FGFR2) is a critical signaling protein involved in various cellular
Externí odkaz:
https://doaj.org/article/949016c0b9af465587dfc868099a92e8
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
FGFR2 fusion is one of the classes of emerging therapeutic targets of precision oncology and is observed in many solid tumor types. Our understanding of oncogenic mechanisms and therapy effects of molecular targets tends to reflect those occurring in
Externí odkaz:
https://doaj.org/article/0fc3e107d3ce4eaf992b9d850c453469
Publikováno v:
Current Oncology, Vol 31, Iss 8, Pp 4305-4317 (2024)
Gastric cancer (GC) represents a major global health challenge as a highly prevalent disease with high mortality whose global incidence and mortality are predicted to worsen over the coming years. To date, our standard of care for advanced gastric ca
Externí odkaz:
https://doaj.org/article/633e4c714ea2473fad94192cc842ccc1
Autor:
Mar Ros-Buxó, Ezequiel Mauro, Tamara Sauri, Gemma Iserte, Carla Fuster-Anglada, Alba Díaz, Laura Sererols-Viñas, Silvia Affo, Alejandro Forner
Publikováno v:
Current Oncology, Vol 31, Iss 7, Pp 3615-3629 (2024)
Biliary tract cancers (BTCs) are rare and aggressive malignancies with an increasing incidence and poor prognosis. The standard systemic treatment for BTCs has evolved to include immune checkpoint inhibitors associated with gemcitabine–cisplatin as
Externí odkaz:
https://doaj.org/article/d3670fc29c4b4469b7fd093524993fbf
Autor:
Chih-Ping Chen, Jian-Pei Huang, Kun-Shuo Huang, Yi-Yung Chen, Fang-Tzu Wu, Yen-Ting Pan, Chien-Ling Chiu, Wayseen Wang
Publikováno v:
Taiwanese Journal of Obstetrics & Gynecology, Vol 63, Iss 3, Pp 387-390 (2024)
Objective: We present perinatal imaging findings of a fetus with Pfeiffer syndrome and a heterozygous c.1019A>G, p.Tyr340Cys (Y340C) mutation in FGFR2 presenting a cloverleaf skull, craniosynostosis and short limbs on prenatal ultrasound mimicking th
Externí odkaz:
https://doaj.org/article/efa37a57cf2c4f2c903310a1f3e459a8
Autor:
Monika Gorska-Arcisz, Marta Popeda, Marcin Braun, Dominika Piasecka, Joanna I. Nowak, Kamila Kitowska, Grzegorz Stasilojc, Marcin Okroj, Hanna M. Romanska, Rafal Sadej
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-22 (2024)
Abstract Background Genetic abnormalities in the FGFR signalling occur in 40% of breast cancer (BCa) patients resistant to anti-ER therapy, which emphasizes the potential of FGFR-targeting strategies. Recent findings indicate that not only mutated FG
Externí odkaz:
https://doaj.org/article/caa8231081c84d09b14913c64fbf8aae
Autor:
Nanfang Xu, Kan-Lin Hung, Xiaoli Gong, Dongwei Fan, Yinglun Tian, Ming Yan, Yuan Wei, Shenglin Wang
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Background Klippel–Feil syndrome (KFS) is a rare congenital disorder characterized by the fusion of two or more cervical vertebrae during early prenatal development. This fusion results from a failure of segmentation during the first trime
Externí odkaz:
https://doaj.org/article/225eb10bf8eb43cb9474c9164b904072
Autor:
N. V. Mitiushkina, E. N. Imyanitov
Publikováno v:
Сибирский онкологический журнал, Vol 23, Iss 1, Pp 130-141 (2024)
The aim of the study was to assess the frequency and clinical significance of various molecular genetic aberrations in biliary tract tumors and to determine the optimal methods of their testing. Material and Methods. We searched the literature source
Externí odkaz:
https://doaj.org/article/5146f49b9ec74b2eadaeffab7139f122