Zobrazeno 1 - 10
of 2 851
pro vyhledávání: '"Fgfr1"'
Autor:
Shuai Fan, Yuxin Chen, Wenyu Wang, Wanting Xu, Mei Tian, Yuetong Liu, Yutong Zhou, Dan Liu, Qin Xia, Lei Dong
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 11, Pp 13131-13150 (2024)
FGFR1 is a key member of the fibroblast growth factor receptor family, mediating critical signaling pathways such as RAS-MAPK and PI3K-AKT. which are integral to regulating essential cellular processes, including proliferation, differentiation, and s
Externí odkaz:
https://doaj.org/article/09d94349025d4808995a33dec426c932
Publikováno v:
Asian Journal of Andrology, Vol 26, Iss 4, Pp 426-432 (2024)
Fibroblast growth factor receptor 1 (FGFR1) mutations are associated with congenital hypogonadotropic hypogonadism (CHH) through inheritance or spontaneous occurrence. We detected FGFR1 mutations in a Chinese cohort of 210 CHH patients at Peking Unio
Externí odkaz:
https://doaj.org/article/f8e12e0c33064e8ea9f8759bc105d73e
Autor:
Yanran Bi, Ruiling Zheng, Jiahao Hu, Ruiqing Shi, Junfeng Shi, Yutao Wang, Peng Wang, Wenyi Jiang, Gyudong Kim, Zhiguo Liu, Xiaokun Li, Li Lin
Publikováno v:
Genes and Diseases, Vol 11, Iss 1, Pp 479-494 (2024)
Glioblastoma (GBM) is a malignant brain tumor that grows quickly, spreads widely, and is resistant to treatment. Fibroblast growth factor receptor (FGFR)1 is a receptor tyrosine kinase that regulates cellular processes, including proliferation, survi
Externí odkaz:
https://doaj.org/article/e1c66d690f71456aac0e238237e5caf8
Autor:
Dominika Żukowska, Aleksandra Chorążewska, Krzysztof Ciura, Aleksandra Gędaj, Marta Kalka, Marta Poźniak, Natalia Porębska, Łukasz Opaliński
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Fibroblast growth factor receptor 1 (FGFR1) is a N-glycosylated cell surface receptor tyrosine kinase, which upon recognition of specific extracellular ligands, fibroblast growth factors (FGFs), initiates an intracellular signaling. FGFR1 si
Externí odkaz:
https://doaj.org/article/65935c36d3104f28b101dad5fb8822b0
Autor:
Tianxiang Hu, Bo Cheng, Atsuko Matsunaga, Ting Zhang, Xiaocui Lu, Hui Fang, Stephanie F. Mori, Xuexiu Fang, Gavin Wang, Hongyan Xu, Huidong Shi, John K. Cowell
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-20 (2024)
Abstract Background Leukemias driven by activated, chimeric FGFR1 kinases typically progress to AML which have poor prognosis. Mouse models of this syndrome allow detailed analysis of cellular and molecular changes occurring during leukemogenesis. We
Externí odkaz:
https://doaj.org/article/4bb949b779d9401693749daf13e351b5
Autor:
Issahy Cano, Melissa Wild, Urvi Gupta, Suman Chaudhary, Yin Shan Eric Ng, Magali Saint-Geniez, Patricia A. D’Amore, Zhengping Hu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract The endothelial glycocalyx, located at the luminal surface of the endothelium, plays an important role in the regulation of leukocyte adhesion, vascular permeability, and vascular homeostasis. Endomucin (EMCN), a component of the endothelial
Externí odkaz:
https://doaj.org/article/f866f4dfaaaf46d7b2fa5d0f1a92f343
Autor:
Xiong Chen, Jinfu Qian, Shiqi Liang, Jianchang Qian, Wu Luo, Yujuan Shi, Hong Zhu, Xiang Hu, Gaojun Wu, Xiaokun Li, Guang Liang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 4, Pp 1693-1710 (2024)
Protein tyrosine kinases (RTKs) modulate a wide range of pathophysiological events in several non-malignant disorders, including diabetic complications. To find new targets driving the development of diabetic cardiomyopathy (DCM), we profiled an RTKs
Externí odkaz:
https://doaj.org/article/6c14b6a9fb5e4523a1c83f658d7fa81a
Autor:
Vladimira Zlinska, Zuzana Feketova, Aleksandra Czyrek, Julia Chudzian, Martina Lenarcic Zivkovic, Vlad-Constantin Ursachi, Pooja Dudeja, Bohumil Fafilek, Jan Rynes, Gustavo Rico-Llanos, Adolf Koudelka, Tanaya Roy, Martyna Biadun, Vendula Raskova, Katerina Svozilova, Michaela Stroblova, Mateusz Krzyscik, Kalina Hristova, Daniel Krowarsch, Silvie Foldynova-Trantirkova, Malgorzata Zakrzewska, Lukas Trantirek, Pavel Krejci
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 36, Iss 1, Pp 102405- (2025)
Impaired fibroblast growth factor receptor (FGFR) signaling is associated with many human conditions, including growth disorders, degenerative diseases, and cancer. Current FGFR therapeutics are based on chemical inhibitors of FGFR tyrosine kinase ac
Externí odkaz:
https://doaj.org/article/ad06bb25575b42c4981efaaf0a6ec8c5
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Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
BackgroundFibroblast growth factor receptor 1 (FGFR1) is known to play a crucial role in the pathogenesis of asthma, although the precise mechanism remains unclear. This study aims to investigate how DNA methylation-mediated silencing of FGFR1 contri
Externí odkaz:
https://doaj.org/article/aa0e2ac0466d4348bcb9f7483ae84765