Výsledky vyhledávání

Akademický článek

Predicting FFAR4 agonists using structure-based machine learning approach based on molecular fingerprints

Autor: Zaid Anis Sherwani, Syeda Sumayya Tariq, Mamona Mushtaq, Ali Raza Siddiqui, Mohammad Nur-e-Alam, Aftab Ahmed, Zaheer Ul-Haq

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Free Fatty Acid Receptor 4 (FFAR4), a G-protein-coupled receptor, is responsible for triggering intracellular signaling pathways that regulate various physiological processes. FFAR4 agonists are associated with enhancing insulin release and

Externí odkaz: https://doaj.org/article/0cbd32252fec4f7fac3faf5fbba8a4ad

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

FFAR4 activation inhibits lung adenocarcinoma via blocking respiratory chain complex assembly associated mitochondrial metabolism

Autor: Zhe Wang, Jinyou Li, LongFei Wang, Yaowei Liu, Wei Wang, JiaYao Chen, HuiJun Liang, Y. Q. Chen, ShengLong Zhu

Publikováno v: Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-18 (2024)

Abstract Despite notable advancements in the investigation and management of lung adenocarcinoma (LUAD), the mortality rate for individuals afflicted with LUAD remains elevated, and attaining an accurate prognosis is challenging. LUAD exhibits intric

Externí odkaz: https://doaj.org/article/5886ab7982c94a3ea8bc9a1945b2fb66

Zobrazit plný text záznamu

Akademický článek

Central activation of the fatty acid sensor GPR120 suppresses microglia reactivity and alleviates sickness- and anxiety-like behaviors

Autor: Shingo Nakajima, Geneviève Demers, Arturo Israel Machuca-Parra, Zahra Dashtehei Pour, Diane Bairamian, Khalil Bouyakdan, Alexandre Fisette, Anita Kabahizi, Josephine Robb, Demetra Rodaros, Cyril Laurent, Guillaume Ferreira, Nathalie Arbour, Thierry Alquier, Stephanie Fulton

Publikováno v: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-15 (2023)

Abstract G protein-coupled receptor 120 (GPR120, Ffar4) is a sensor for long-chain fatty acids including omega-3 polyunsaturated fatty acids (n-3 PUFAs) known for beneficial effects on inflammation, metabolism, and mood. GPR120 mediates the anti-infl

Externí odkaz: https://doaj.org/article/f87ce8b1f2204c9eb17e5b7be56e1bd7

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Akkermansia muciniphila supplementation improves glucose tolerance in intestinal Ffar4 knockout mice during the daily light to dark transition

Autor: Zhe Wang, Siyuan Cui, TingTing Zhang, Wei Wang, JiaYu Li, Y. Q. Chen, Sheng long Zhu

Publikováno v: mSystems, Vol 8, Iss 5 (2023)

ABSTRACT Disruption of blood glucose utilization may lead to diabetes mellitus, which has complex genetic and environmental aspects, and free fatty acid receptors (FFARs) may bridge the genetic and dietary aspects. FFAR4 has been identified as a new

Externí odkaz: https://doaj.org/article/3238b882f8ce49658f564f36210578a3

Zobrazit plný text záznamu

Akademický článek

GPCR-mediated effects of fatty acids and bile acids on glucose homeostasis

Autor: Antwi-Boasiako Oteng, Liu Liu

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

Fatty acids and glucose are key biomolecules that share several commonalities including serving as energy substrates and as signaling molecules. Fatty acids can be synthesized endogenously from intermediates of glucose catabolism via de-novo lipogene

Externí odkaz: https://doaj.org/article/c37cc58a2da94ebea9ce64d0fc219b85

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome

Autor: Naixin Zhang, Brian Harsch, Michael J. Zhang, Dylan J. Gyberg, Jackie A. Stevens, Brandon M. Wagner, Jenna Mendelson, Michael T. Patterson, Devin A. Orchard, Chastity L. Healy, Jesse W. Williams, DeWayne Townsend, Gregory C. Shearer, Katherine A. Murphy, Timothy D. O'Connell

Publikováno v: Journal of Lipid Research, Vol 64, Iss 6, Pp 100374- (2023)

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome, but a predominant subset of HFpEF patients has metabolic syndrome (MetS). Mechanistically, systemic, nonresolving inflammation associated with MetS might drive HFp

Externí odkaz: https://doaj.org/article/c4ae48406a7f4bc885e88878c82ca9d0

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids

Autor: Tomotaka Nagasawa, Masaki Horitani, Shin‐ichi Kawaguchi, Shigeki Higashiyama, Yoichiro Hama, Susumu Mitsutake

Publikováno v: FEBS Open Bio, Vol 11, Iss 11, Pp 3081-3089 (2021)

Free fatty acid receptor 4 (FFAR4)/GPR120 comprises a receptor for medium‐ and long‐chain fatty acids. We previously identified phytosphingosine (PHS) as a novel ligand of FFAR4. Although many natural FFAR4 ligands have carboxyl groups, PHS does

Externí odkaz: https://doaj.org/article/fe7b075bd2064db99a4e381cddb5c74c

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání