Výsledky vyhledávání

Impact of various central endoscopy reading models on treatment outcome in Crohn's disease using data from the randomized, controlled, exploratory cohort arm of the BERGAMOT trial

Autor: Fez Hussain, Marco Daperno, Daniel S. Mishkin, Azra Hassanali, Young S Oh, Stefan Schreiber, Rhian Jacob, Walter Reinisch

Publikováno v: Gastrointestinal endoscopy. 93(1)

Background and Aims Endoscopic assessment of mucosal appearance by independent central reading has become the standard method to assess Crohn’s disease activity in clinical trials. The performance characteristics of various endoscopy reading models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6a315f7cceacd604fc96b9f3fd5e60
https://pubmed.ncbi.nlm.nih.gov/33353616

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Central Endoscopy Reading in Inflammatory Bowel Diseases: Table 1

Autor: Brian G. Feagan, Barrett G. Levesque, Simon Travis, Fez Hussain, Julián Panés

Publikováno v: Journal of Crohn's and Colitis. 10:S542-S547

Endoscopic assessment of the presence and severity of endoscopic lesions has become an essential part of clinical trials in ulcerative colitis and Crohn's disease, for both patient eligibility and outcome measures. Variability in lesion interpretatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e76e3a76980479e59dec386db5b574d8
https://doi.org/10.1093/ecco-jcc/jjv171

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Su1928 EVALUATING ASSOCIATION BETWEEN FECAL CALPROTECTIN AND ENDOSCOPIC OUTCOMES IN ULCERATIVE COLITIS USING THE HICKORY OPEN-LABEL INDUCTION COHORT

Autor: Fez Hussain, Young S. Oh, Marco Daperno, Stuart R. Lacey, Bouchra El Azzouzi, Walter Reinisch, Azra Hassanali, Daniel S. Mishkin, Regan Li, K T Park

Publikováno v: Gastroenterology. 158:S-706

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6555e45303ab354b9bc1da31e7014227
https://doi.org/10.1016/s0016-5085(20)32454-9

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P233 Evaluating the association between faecal calprotectin and endoscopic outcomes in ulcerative colitis using the HICKORY open-label induction cohort

Autor: Daniel S. Mishkin, K T Park, Regan Li, Marco Daperno, Young S Oh, Fez Hussain, Azra Hassanali, B El Azzouzi, Walter Reinisch, Stuart Lacey

Publikováno v: Journal of Crohn's and Colitis. 14:S259-S259

Background In clinical practice, faecal calprotectin (FC) is used to monitor disease activity in ulcerative colitis (UC); however, there is no consensus on optimal cut-off values of FC for predicting endoscopic outcomes. FC performance has not been e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09acd66546b7573c46d8909fa81f01bc
https://doi.org/10.1093/ecco-jcc/jjz203.362

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Development of drugs for celiac disease: review of endpoints for Phase 2 and 3 trials

Autor: Fez Hussain, Joseph A. Murray, Klaus Gottlieb, Jill Dawson

Publikováno v: Gastroenterology Report

Celiac disease is a lifelong disorder for which there is currently only one known, effective treatment: a gluten-free diet. New treatment approaches have recently emerged; several drugs are in Phase 2 trials and results appear promising; however, dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df5e5db9522fefeb21a5d61ee988953
http://europepmc.org/articles/PMC4423465

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856 Evaluation of Paired and Separated Endoscopic Reads at Baseline and Week 14 in the Exploratory BERGAMOT Induction Cohort

Autor: Regan Li, Stuart Lacey, Azra Hassanali, Walter Reinisch, Stefan Schreiber, Fez Hussain, Marco Daperno, Young S. Oh, Daniel S. Mishkin

Publikováno v: American Journal of Gastroenterology. 114:S495-S495

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e77e973c45e8b2a2a4185b6a36b94074
https://doi.org/10.14309/01.ajg.0000592960.94504.fc

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Central Reading of Endoscopy Endpoints in Inflammatory Bowel Disease Trials

Autor: Brian G. Feagan, William J. Sandborn, Paul Rutgeerts, Klaus Gottlieb, Simon Travis, Fez Hussain

Publikováno v: Europe PubMed Central

BACKGROUND: Central reading of endoscopy (CROE) is crucial in determining who qualifies for a trial but also has a role, independent of the selected scoring system, in decreasing measurement noise that can obscure separation between placebo and activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e746f950e5d1dba01a86ebaaaf4ab9aa
http://ora.ox.ac.uk/objects/uuid:4aa420c5-e34a-455c-aa82-49a8bfeacf79

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The 2 + 1 paradigm: an efficient algorithm for central reading of Mayo endoscopic subscores in global multicenter phase 3 ulcerative colitis clinical trials

Autor: Klaus Gottlieb, Fez Hussain, Harris A. Ahmad

Publikováno v: Gastroenterology Report
Europe PubMed Central

Despite its importance and potential impact in clinical trials, central reading continues to be an under-represented topic in the literature about inflammatory bowel disease (IBD) clinical trials. Although several IBD studies have incorporated centra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18f13291610326d0bdccf5ed63019a4
https://pubmed.ncbi.nlm.nih.gov/26361984

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Voting for Image Scoring and Assessment (VISA) - theory and application of a 2 + 1 reader algorithm to improve accuracy of imaging endpoints in clinical trials

Autor: Klaus Gottlieb, Fez Hussain

Publikováno v: BMC Medical Imaging

Independent central reading or off-site reading of imaging endpoints is increasingly used in clinical trials. Clinician-reported outcomes, such as endoscopic disease activity scores, have been shown to be subject to bias and random error. Central rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db07fc146be9c33cc3bdce505b8ad3c3
https://doi.org/10.1186/s12880-015-0049-0

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