Signal peptide exchange alters HIV-1 envelope antigenicity and immunogenicity.

Autor: Upadhyay C; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Rao P; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Behzadi MA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Feyznezhad R; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Lambert GS; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Kumar R; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Kumar M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Yang W; Department of Pathology, Johns Hopkins University, Baltimore, MD, United States., Jiang X; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, United States., Luo CC; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, United States., Nadas A; Department of Environment Medicine, New York University Grossman School of Medicine, New York, NY, United States., Arthos J; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States., Kong XP; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, United States., Zhang H; Department of Pathology, Johns Hopkins University, Baltimore, MD, United States., Hioe CE; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Research Service, James J. Peters VA Medical Center, Bronx, NY, United States., Duty JA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Sep 24; Vol. 15, pp. 1476924. Date of Electronic Publication: 2024 Sep 24 (Print Publication: 2024).

Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice.

Autor: Hioe CE; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; James J. Peters VA Medical Center, Bronx, New York, New York, United States of America., Li G; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America., Liu X; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Tsahouridis O; Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America., He X; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Funaki M; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Klingler J; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; James J. Peters VA Medical Center, Bronx, New York, New York, United States of America., Tang AF; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; School of Medicine, University of California, San Francisco, California, United States of America., Feyznezhad R; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Heindel DW; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Wang XH; VA New York Harbor Healthcare System-Manhattan, New York, New York, United States of America., Spencer DA; Division of Pathobiology & Immunology, Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, Oregon, United States of America., Hu G; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America., Satija N; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Prévost J; Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada., Finzi A; Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada., Hessell AJ; Division of Pathobiology & Immunology, Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, Oregon, United States of America., Wang S; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America., Lu S; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America., Chen BK; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Zolla-Pazner S; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Upadhyay C; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Alvarez R; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Su L; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis and Cancer, Institute of Human Virology, Departments of Pharmacology and Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2022 Jan 05; Vol. 18 (1), pp. e1010183. Date of Electronic Publication: 2022 Jan 05 (Print Publication: 2022).

A cross-reactive mouse monoclonal antibody against rhinovirus mediates phagocytosis in vitro.

Autor: Behzadi MA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Choi A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Duehr J; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Feyznezhad R; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Upadhyay C; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Schotsaert M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nachbagauer R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. raffael.nachbagauer@mssm.edu.

Publikováno v: Scientific reports [Sci Rep] 2020 Jun 16; Vol. 10 (1), pp. 9750. Date of Electronic Publication: 2020 Jun 16.

Beyond bNAbs: Uses, Risks, and Opportunities for Therapeutic Application of Non-Neutralising Antibodies in Viral Infection.

Autor: Mader, Kahlio¹ (AUTHOR), Dustin, Lynn B.¹ (AUTHOR) lynn.dustin@kennedy.ox.ac.uk

Publikováno v: Antibodies (2073-4468). Jun2024, Vol. 13 Issue 2, p28. 17p.

Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations.

Autor: Upadhyay C; Icahn School of Medicine at Mount Sinai, Division of Infectious Diseases, New York, New York, United States of America., Feyznezhad R; Icahn School of Medicine at Mount Sinai, Division of Infectious Diseases, New York, New York, United States of America., Yang W; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States of America., Zhang H; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States of America., Zolla-Pazner S; Icahn School of Medicine at Mount Sinai, Division of Infectious Diseases, New York, New York, United States of America., Hioe CE; Icahn School of Medicine at Mount Sinai, Division of Infectious Diseases, New York, New York, United States of America.; James J. Peters Veterans Affairs Medical Center, Research Service, Bronx, New York, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2018 Jan 25; Vol. 14 (1), pp. e1006812. Date of Electronic Publication: 2018 Jan 25 (Print Publication: 2018).