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Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors.

Autor: Sharp PP; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia., Garnier JM; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia., Hatfaludi T; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia., Xu Z; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia., Segal D; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia., Jarman KE; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia., Jousset H; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia., Garnham A; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia., Feutrill JT; Synthesis MedChem, 399 Royal Parade, Parkville, VIC 3052, Australia., Cuzzupe A; Synthesis MedChem, 399 Royal Parade, Parkville, VIC 3052, Australia., Hall P; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia., Taylor S; St. Vincent's Institute of Medical Research and Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, VIC 3052, Australia., Walkley CR; St. Vincent's Institute of Medical Research and Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, VIC 3052, Australia., Tyler D; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Dawson MA; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.; Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, East Melbourne, VIC 3002, Australia., Czabotar P; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia., Wilks AF; Synthesis MedChem, 399 Royal Parade, Parkville, VIC 3052, Australia., Glaser S; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia., Huang DCS; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia., Burns CJ; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia.; School of Chemistry, The Bio21 Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2017 Nov 14; Vol. 8 (12), pp. 1298-1303. Date of Electronic Publication: 2017 Nov 14 (Print Publication: 2017).

Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).

Autor: Burns CJ; Cytopia Research Pty Ltd, 576 Swan St, Richmond, VIC 3121, Australia., Bourke DG, Andrau L, Bu X, Charman SA, Donohue AC, Fantino E, Farrugia M, Feutrill JT, Joffe M, Kling MR, Kurek M, Nero TL, Nguyen T, Palmer JT, Phillips I, Shackleford DM, Sikanyika H, Styles M, Su S, Treutlein H, Zeng J, Wilks AF

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Oct 15; Vol. 19 (20), pp. 5887-92. Date of Electronic Publication: 2009 Aug 23.