Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers.

Autor: Grippo JF; Roche Innovation Center, New York, New York, USA., Folitar I; Roche Innovation Center, Basel, Switzerland., Passe S; Roche Innovation Center, New York, New York, USA., Jiang Q; Roche Innovation Center Shanghai, Shanghai, China., Rodriguez I; Roche Innovation Center, New York, New York, USA., Fettner SH; Roche Innovation Center, New York, New York, USA., Calleja E; Roche Innovation Center, New York, New York, USA.

Publikováno v: Clinical and translational science [Clin Transl Sci] 2021 Jul; Vol. 14 (4), pp. 1524-1534. Date of Electronic Publication: 2021 Apr 09.

A phase Ib dose-escalation study of erlotinib, capecitabine and oxaliplatin in metastatic colorectal cancer patients.

Autor: Van Cutsem E; University Hospital Gasthuisberg, Leuven, Belgium. eric.vancutsem@uz.kuleuven.ac.be, Verslype C, Beale P, Clarke S, Bugat R, Rakhit A, Fettner SH, Brennscheidt U, Feyereislova A, Delord JP

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2008 Feb; Vol. 19 (2), pp. 332-9. Date of Electronic Publication: 2007 Nov 06.

Pharmacokinetic-pharmacodynamic (PK-PD) modeling for a new antihypertensive agent (neutral metalloendopeptidase inhibitor SCH 42354) in patients with mild to moderate hypertension.

Autor: Fettner SH; Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Kenilworth, NJ 07033-0530, USA., Pai S, Zhu GR, Kosoglou T, Banfield CR, Batra V

Publikováno v: European journal of clinical pharmacology [Eur J Clin Pharmacol] 1995; Vol. 48 (5), pp. 351-9.

Considering the Oral Bioavailability of Protein Kinase Inhibitors: Essential in Assessing the Extent of Drug–Drug Interaction and Improving Clinical Practice.

Autor: Le Louedec, Félicien, Puisset, Florent, Chatelut, Etienne, Tod, Michel

Publikováno v: Clinical Pharmacokinetics; Jan2023, Vol. 62 Issue 1, p55-66, 12p

Identification of rifampin-regulated functional modules and related microRNAs in human hepatocytes based on the protein interaction network.

Autor: Jin Li¹, Ying Wang^1,2, Lei Wang¹, Xuefeng Dai², Wang Cong¹, Weixing Feng¹, Chengzhen Xu¹, Yulin Deng¹, Yue Wang³, Skaar, Todd C.⁴, Hong Liang^1,5 lh@hrbeu.edu.cn, Yunlong Liu^1,3,5 yunliu@iupui.edu

Publikováno v: BMC Genomics. 8/22/2016, Vol. 17, p259-270. 12p. 5 Diagrams, 5 Charts, 1 Graph.