CRISPR-Cas9 mediated endogenous utrophin upregulation improves Duchenne Muscular Dystrophy

Autor: Simon Guiraud, Sumitava Dastidar, Fetta Mazed, Fatima Amor, Maelle Ralu, Anne de Cian, Isabelle Richard, Giuseppe Ronzitti, Francesco Saverio Tedesco, Mario Amendola

Duchenne muscular dystrophy (DMD) is a lethal neuromuscular disorder caused by loss of dystrophin. Upregulation of utrophin (UTRN), a dystrophin paralogue, is a promising therapeutic avenue. Here, we present a CRISPR-Cas9-mediated strategy to increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::159ae072038fc356fb00d2e0d1aa60ca
https://doi.org/10.1101/2023.04.18.536394

Supplementary Table S3 from Extracellular ATP and CD39 Activate cAMP-Mediated Mitochondrial Stress Response to Promote Cytarabine Resistance in Acute Myeloid Leukemia

Autor: Jean-Emmanuel Sarry, François Vergez, Christian Récher, Jérome Tamburini, Carine Joffre, Tony Kaoma, Francisco Azuaje, Nathalie Nicot, Jean-Charles Portais, Floriant Bellvert, Nathalie Bonnefoy, Mathilde Gotanègre, Camille Laurent, Charlotte Syrykh, Muriel Picard, Massimiliano Bardotti, Sarah Gandarillas, Latifa Jarrou, Clément Larrue, Fetta Mazed, Marie Sabatier, Lucille Stuani, Claudie Bosc, Thomas Farge, Pierre-Luc Mouchel, Mohsen Hosseini, Fabienne de Toni, Ryan Gwilliam, Estelle Saland, Marie-Laure Nicolau-Travers, Margherita Ghisi, Emeline Boet, Nesrine Aroua

Table S3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f4b4eca73a9c2b7e69352f0d00ca0b
https://doi.org/10.1158/2159-8290.22536358.v1

Supplementary Table S5 from Extracellular ATP and CD39 Activate cAMP-Mediated Mitochondrial Stress Response to Promote Cytarabine Resistance in Acute Myeloid Leukemia

Autor: Jean-Emmanuel Sarry, François Vergez, Christian Récher, Jérome Tamburini, Carine Joffre, Tony Kaoma, Francisco Azuaje, Nathalie Nicot, Jean-Charles Portais, Floriant Bellvert, Nathalie Bonnefoy, Mathilde Gotanègre, Camille Laurent, Charlotte Syrykh, Muriel Picard, Massimiliano Bardotti, Sarah Gandarillas, Latifa Jarrou, Clément Larrue, Fetta Mazed, Marie Sabatier, Lucille Stuani, Claudie Bosc, Thomas Farge, Pierre-Luc Mouchel, Mohsen Hosseini, Fabienne de Toni, Ryan Gwilliam, Estelle Saland, Marie-Laure Nicolau-Travers, Margherita Ghisi, Emeline Boet, Nesrine Aroua

Table S5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4e1be999918da9e75e1b163ae18e19
https://doi.org/10.1158/2159-8290.22536352.v1

Extracellular ATP and CD39 Activate cAMP-Mediated Mitochondrial Stress Response to Promote Cytarabine Resistance in Acute Myeloid Leukemia

Autor: Margherita Ghisi, Jerome Tamburini, Marie Sabatier, Massimiliano Bardotti, Francisco Azuaje, Jean-Charles Portais, Christian Récher, Carine Joffre, Lucille Stuani, Pierre-Luc Mouchel, Camille Laurent, Marie-Laure Nicolau-Travers, Fetta Mazed, Claudie Bosc, Nathalie Nicot, Nesrine Aroua, Mathilde Gotanègre, Jean-Emmanuel Sarry, Estelle Saland, Clément Larrue, Floriant Bellvert, Fabienne De Toni, Latifa Jarrou, Mohsen Hosseini, Charlotte Syrykh, Ryan Gwilliam, François Vergez, Tony Kaoma, Sarah Gandarillas, Muriel Picard, Thomas Farge, Emeline Boet, Nathalie Bonnefoy

Publikováno v: Cancer Discovery
Cancer Discovery, 2020, 10 (10), pp.1544-1565. ⟨10.1158/2159-8290.CD-19-1008⟩
Cancer Discovery, American Association for Cancer Research, 2020, 10 (10), pp.1544-1565. ⟨10.1158/2159-8290.CD-19-1008⟩

Relapses driven by chemoresistant leukemic cell populations are the main cause of mortality for patients with acute myeloid leukemia (AML). Here, we show that the ectonucleotidase CD39 (ENTPD1) is upregulated in cytarabine-resistant leukemic cells fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d1d987207bbabb0832871f8ebdd298
https://hal.inrae.fr/hal-02983257

RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia

Autor: Rudy Birsen, Didier Bouscary, Christian Récher, Nathalie Jacque, Pierre Sujobert, M. Le Gall, Estelle Saland, Laury Poulain, Fetta Mazed, V Salnot, Alexa S. Green, Michaela Fontenay, Clément Larrue, Patrick Mayeux, Olivier Kosmider, E.F. Gautier, Arnaud Jacquel, Justine Decroocq, Jerome Tamburini, J-E Sarry, Mireille Lambert, Patrick Auberger, Johanna Mondesir

Publikováno v: Leukemia
Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 2018, 32 (3), pp.597-605. ⟨10.1038/leu.2017.284⟩

Acute myeloid leukemia (AML) with the FLT3 internal tandem duplication (FLT3-ITD AML) accounts for 20–30% of AML cases. This subtype usually responds poorly to conventional therapies, and might become resistant to FLT3 tyrosine kinase inhibitors (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dca7c172c1409d54329a8aa2fa318f5
https://pubmed.ncbi.nlm.nih.gov/28914261