Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Fetene Tekle"'
Autor:
Mohamed Kreir, Dea Putri, Fetene Tekle, Francesca Pibiri, Constantin d’Ydewalle, Karel Van Ammel, Helena Geys, Ard Teisman, David J. Gallacher, Hua Rong Lu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
We investigated drug-induced acute neuronal electrophysiological changes using Micro-Electrode arrays (MEA) to rat primary neuronal cell cultures. Data based on 6-key MEA parameters were analyzed for plate-to-plate vehicle variability, effects of pos
Externí odkaz:
https://doaj.org/article/6519f93f4908451c87b4f64f1cc25244
Autor:
Hua-Rong Lu, Manabu Seo, Mohamed Kreir, Tetsuya Tanaka, Rie Yamoto, Cristina Altrocchi, Karel van Ammel, Fetene Tekle, Ly Pham, Xiang Yao, Ard Teisman, David J. Gallacher
Publikováno v:
Cells, Vol 12, Iss 6, p 958 (2023)
Drug-induced seizure liability is a significant safety issue and the basis for attrition in drug development. Occurrence in late development results in increased costs, human risk, and delayed market availability of novel therapeutics. Therefore, the
Externí odkaz:
https://doaj.org/article/30146c9b38b545e3a4445329880d9e44
Autor:
Hua Rong Lu, Mohamed Kreir, Van Ammel Karel, Fetene Tekle, Danny Geyskens, Ard Teisman, David J. Gallacher
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Introduction: Early identification of cardiac risk is essential for reducing late-stage attrition in drug development. We adapted the previously published cardiac hazard risk-scoring system using a calcium transient assay in human stem cell-derived C
Externí odkaz:
https://doaj.org/article/55eee77037354205947cc96ae57ef5ed
Autor:
Deborah Dhuyvetter, Fetene Tekle, Maxim Nazarov, Rob J. Vreeken, Herman Borghys, Frederik Rombouts, Ilse Lenaerts, Astrid Bottelbergs
Publikováno v:
Drug Delivery, Vol 27, Iss 1, Pp 1597-1607 (2020)
The blood–brain barrier (BBB) is often a limiting factor for getting drugs in the brain. Bypassing the BBB by intranasal (IN), or also called nose to brain (NTB), route is an interesting and frequently investigated concept for brain drug delivery.
Externí odkaz:
https://doaj.org/article/3a2c73fb65e34179bd76465154cdf0e3
Autor:
Ivan Kopljar, Hua Rong Lu, Karel Van Ammel, Martin Otava, Fetene Tekle, Ard Teisman, David J. Gallacher
Publikováno v:
Stem Cell Reports, Vol 11, Iss 6, Pp 1365-1377 (2018)
Summary: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising cardiac safety platform, demonstrated by numerous validation studies using drugs with known cardiac adverse effects in humans. However, the ch
Externí odkaz:
https://doaj.org/article/c94301ff0e65459abf10dca1af2b44a1
Autor:
Chelsea Fischer, Iosune Ibiricu Urriza, Christina A Bulman, K C Lim, Jiri Gut, Sophie Lachau-Durand, Marc Engelen, Ludo Quirynen, Fetene Tekle, Benny Baeten, Brenda Beerntsen, Sara Lustigman, Judy Sakanari
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0006787 (2019)
River blindness and lymphatic filariasis are two filarial diseases that globally affect millions of people mostly in impoverished countries. Current mass drug administration programs rely on drugs that primarily target the microfilariae, which are re
Externí odkaz:
https://doaj.org/article/242d359b1ba14723bac1cecbb901a1d9
Autor:
Hanna T Sjoberg, Nicolas Pionnier, Ghaith Aljayyoussi, Haelly M Metuge, Abdel J Njouendou, Valerine C Chunda, Fanny F Fombad, Dizzle B Tayong, Narcisse V T Gandjui, Desmond N Akumtoh, Patrick W N Chounna, Bertrand L Ndzeshang, Sophie Lachaud, Fetene Tekle, Ludo Quirynen, Marc Engelen, Benny Baeten, Andrew Steven, Stephen A Ward, Mark J Taylor, Samuel Wanji, Joseph D Turner
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0006356 (2019)
The Onchocerca ochengi adult implant and Brugia malayi microfilariemic Severe-Combined Immunodeficient (SCID) mouse models are validated screens to measure macrofilaricidal and microfilaricidal activities of candidate onchocerciasis drugs. The purpos
Externí odkaz:
https://doaj.org/article/fe1c618c58354c30b115c91c359195be
Autor:
Marc P Hübner, Alexandra Ehrens, Marianne Koschel, Bettina Dubben, Franziska Lenz, Stefan J Frohberger, Sabine Specht, Ludo Quirynen, Sophie Lachau-Durand, Fetene Tekle, Benny Baeten, Marc Engelen, Charles D Mackenzie, Achim Hoerauf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0006320 (2019)
Flubendazole (FBZ) is highly efficacious against filarial nematodes after parenteral administration and presents a promising macrofilaricidal drug candidate for the elimination of onchocerciasis and other filariae. In the present study the efficacy o
Externí odkaz:
https://doaj.org/article/b3ac1e90612a4f61bf8699e5f26adb14
Autor:
Hanneke Drewes, Janneke van Til-de Jong, Jeroen Struijs, Caroline Baan, Fetene Tekle, Bert Meijboom, Gert Westert
Publikováno v:
International Journal of Integrated Care, Vol 12, Iss 8 (2012)
Background: The patient assessment of chronic illness care (PACIC) is a promising instrument to evaluate the chronic care experiences of patients, yet additional validation is needed to improve its usefulness.Methods: A total of 1941 patients with di
Externí odkaz:
https://doaj.org/article/4489cc6d6bbc4d0cb24a9cd639625b89
Publikováno v:
In Journal of Pharmacological and Toxicological Methods July-August 2020 104