Chronic in utero mitral inflow obstruction unloads left ventricular volume in a novel late gestation fetal lamb modelCentral MessagePerspective

Autor: Daisuke Onohara, MD, PhD, Matthew Hagen, PhD, Samantha Louey, PhD, George Giraud, MD, PhD, Sonnet Jonker, PhD, Muralidhar Padala, PhD

Publikováno v: JTCVS Open, Vol 16, Iss , Pp 698-707 (2023)

Objective: The in utero no flow/no grow hypothesis postulates that reduced inflow of blood into the left ventricle due to a stenotic mitral valve could lead to ventricular hypoplasia and hypoplastic left heart syndrome. This has been demonstrated in

Externí odkaz: https://doaj.org/article/31015283eadb4b4a96395f45133de81f

An Artificial Placenta Experimental System in Sheep: Critical Issues for Successful Transition and Survival up to One Week

Autor: Elisenda Eixarch, Miriam Illa, Raquel Fucho, Kambiz Rezaei, Ameth Hawkins-Villarreal, Sara Bobillo-Pérez, Paula C. Randanne, Miguel Moran, Marina Chorda, Sergio Sanchez-Martinez, Yolanda J. D. de Roo-Puente, Maria del Mar Velilla, Ruth del Rio, Marc Gallego, Daniel Sanin-Ramirez, Victor Narvaez, Fatima Crispi, Elisenda Bonet-Carne, Eduard Gratacos

Publikováno v: Biomedicines, Vol 11, Iss 3, p 702 (2023)

Objective: To describe the development of an artificial placenta (AP) system in sheep with learning curve and main bottlenecks to allow survival up to one week. Methods: A total of 28 fetal sheep were transferred to an AP system at 110–115 days of

Externí odkaz: https://doaj.org/article/eee599bcbf8740709bb9071dce1ded86

The EXTrauterine Environment for Neonatal Development Supports Normal Intestinal Maturation and Development

Autor: Aimee G Kim, Melissa N. Orr, Robert O. Heuckeroth, Kendall M. Lawrence, Haiying Li, Heron D. Baumgarten, William H. Peranteau, Marcus G. Davey, Grace Hwang, Ali Y. Mejaddam, Lauren J. Brown, Christina M. Wright, Alan W. Flake, Barbara E. Coons, Zoya Butt, Patrick E. McGovern, Ronald C. Rubenstein, Avery C. Rossidis, Antoneta Radu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 623-637 (2020)

Background and Aims The Extra-Uterine Environment for Neonatal Development (EXTEND) aims to avoid the complications of prematurity, such as NEC. Our goal was to determine if bowel development occurs normally in EXTEND-supported lambs, with specific e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e844cee198714a018c7bd1873f98d86e
https://doi.org/10.1016/j.jcmgh.2020.05.006

Pharmacokinetics and pharmacodynamics of sildenafil in fetal lambs on extracorporeal support

Autor: Zexuan Yang, Marcus G. Davey, Pieter Annaert, Barbara E. Coons, Felix De Bie, Chengcheng Pang, Francesca Maria Russo, James Moon, Janaina C. Senra, Camilla Omann, Jan Deprest, Pieter Van Brantegem, Karel Allegaert, Alan W. Flake

Publikováno v: Biomedicine & Pharmacotherapy, Vol 143, Iss, Pp 112161-(2021)
Biomedicine and Pharmacotherapy, 143:112161. Elsevier Masson

BACKGROUND: Maternal transplacental administration of sildenafil is being considered for a variety of fetal conditions. Clinical translation also requires evaluation of fetal safety in a higher species, such as the fetal lamb. Experiments with the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8ac41eafb699a7120de7992ed5e74f
https://lirias.kuleuven.be/handle/123456789/682523

New insights into congenital diaphragmatic hernia (CDH)- a surgeon’s introduction to CDH animal models.

Autor: Priscilla Pui Lam Chiu

Publikováno v: Frontiers in Pediatrics, Vol 2 (2014)

In recent decades, new research into the developmental defects and pathophysiological basis of congenital diaphragmatic hernia has revealed opportunities for the development of innovative therapies. Importantly, the use of animal models to represent

Externí odkaz: https://doaj.org/article/497d5caedae24ab2aceea44ca4930b39