Retinoic acid signaling acts as a rheostat to balance Treg function.

Autor: Thangavelu G; Department of Pediatrics, Center for Immunology, University of Minnesota, Minneapolis, MN, USA. govindarajan.thangavelu@gmail.com., Andrejeva G; Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA., Bolivar-Wagers S; Department of Pediatrics, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Jin S; Department of Pediatrics, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Zaiken MC; Department of Pediatrics, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Loschi M; Department of Pediatrics, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Aguilar EG; Department of Pediatrics, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Furlan SN; Department of Pediatrics, University of Washington, Seattle, WA, USA.; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Brown CC; Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lee YC; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Lebanon, USA., Hyman CM; Department of Pediatrics, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Feser CJ; Department of Pediatrics, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Panoskaltsis-Mortari A; Department of Pediatrics, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Hippen KL; Department of Pediatrics, Center for Immunology, University of Minnesota, Minneapolis, MN, USA., MacDonald KP; Department of Immunology, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute and School of Medicine, University of Queensland, Brisbane, QLD, Australia., Murphy WJ; Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, USA., Maillard I; Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hill GR; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Munn DH; Georgia Cancer Center, Augusta University, Augusta, GA, USA., Zeiser R; Department of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Freiburg University Medical Centre, Freiburg, Germany., Kean LS; Boston Children's Hospital and the Dana-Farber Cancer Institute, Boston, MA, USA., Rathmell JC; Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA., Chi H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Noelle RJ; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Lebanon, USA., Blazar BR; Department of Pediatrics, Center for Immunology, University of Minnesota, Minneapolis, MN, USA.

Publikováno v: Cellular & molecular immunology [Cell Mol Immunol] 2022 Jul; Vol. 19 (7), pp. 820-833. Date of Electronic Publication: 2022 May 17.

Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing.

Autor: Knipping F; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA., Newby GA; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., Eide CR; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA., McElroy AN; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA., Nielsen SC; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA., Smith K; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA., Fang Y; Institute for Transfusion Medicine and Gene Therapy, Medical Center, University of Freiburg, Freiburg 79106, Germany; Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Freiburg 79106, Germany; MD Program, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany., Cornu TI; Institute for Transfusion Medicine and Gene Therapy, Medical Center, University of Freiburg, Freiburg 79106, Germany; Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Freiburg 79106, Germany; Faculty of Medicine, University of Freiburg 79106, Germany., Costa C; CIRI - International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, F-69007 Lyon, France., Gutierrez-Guerrero A; CIRI - International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, F-69007 Lyon, France., Bingea SP; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA., Feser CJ; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA., Steinbeck B; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA., Hippen KL; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA., Blazar BR; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA., McCaffrey A; TriLink BioTechnologies, San Diego, CA 92121, USA., Mussolino C; Institute for Transfusion Medicine and Gene Therapy, Medical Center, University of Freiburg, Freiburg 79106, Germany; Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Freiburg 79106, Germany; Faculty of Medicine, University of Freiburg 79106, Germany., Verhoeyen E; CIRI - International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, F-69007 Lyon, France; Université Côte d'Azur, INSERM, C3M, 06204 Nice, France., Tolar J; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., Osborn MJ; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: osbor026@umn.edu.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2022 Jan 05; Vol. 30 (1), pp. 130-144. Date of Electronic Publication: 2021 Nov 02.

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality.

Autor: Saha A; Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA., Taylor PA; Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA., Lees CJ; Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA., Panoskaltsis-Mortari A; Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA., Osborn MJ; Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA., Feser CJ; Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA., Thangavelu G; Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA., Melchinger W; Department of Hematology, Oncology, and Stem-Cell Transplantation, Freiburg University Medical Center, Albert Ludwigs University Freiburg, Freiburg, Germany., Refaeli Y; Department of Dermatology, University of Colorado, Aurora, Colorado, USA., Hill GR; Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA., Munn DH; Department of Pediatrics, Georgia Health Sciences University, Augusta, Georgia, USA., Murphy WJ; Department of Dermatology, UC Davis School of Medicine, Sacramento, California, USA., Serody JS; Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Maillard I; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Kreymborg K; Department of Immunology and Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA., van den Brink M; Department of Immunology and Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Dong C; Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China., Huang S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Zang X; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Allison JP; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Zeiser R; Department of Hematology, Oncology, and Stem-Cell Transplantation, Freiburg University Medical Center, Albert Ludwigs University Freiburg, Freiburg, Germany., Blazar BR; Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA.

Publikováno v: JCI insight [JCI Insight] 2019 Oct 03; Vol. 4 (19). Date of Electronic Publication: 2019 Oct 03.

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease.

Autor: McDonald-Hyman C; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; The Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Muller JT; Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, NYU School of Medicine, New York, New York, USA., Loschi M; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; The Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Thangavelu G; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; The Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Saha A; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; The Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Kumari S; Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, NYU School of Medicine, New York, New York, USA., Reichenbach DK; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; The Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Smith MJ; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; The Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Zhang G; Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, NYU School of Medicine, New York, New York, USA., Koehn BH; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; The Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Lin J; Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, NYU School of Medicine, New York, New York, USA., Mitchell JS; The Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.; Division of Rheumatology, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Fife BT; The Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.; Division of Rheumatology, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Panoskaltsis-Mortari A; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Feser CJ; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Kirchmeier AK; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Osborn MJ; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Hippen KL; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Kelekar A; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Serody JS; Lineberger Comprehensive Cancer Center, Division of Hematology/Oncology, University of North Carolina, Chapel Hill, North Carolina, USA., Turka LA; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA., Munn DH; Department of Pediatrics, Georgia Health Sciences University, Augusta, Georgia, USA., Chi H; Department of Immunology, Saint Jude Children's Research Hospital, Memphis, Tennessee, USA., Neubert TA; Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, NYU School of Medicine, New York, New York, USA., Dustin ML; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom., Blazar BR; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; The Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2018 Oct 01; Vol. 128 (10), pp. 4604-4621. Date of Electronic Publication: 2018 Aug 14.

Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD.

Autor: Matta BM; Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA;, Reichenbach DK; Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN;, Zhang X; Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; Xiangya School of Medicine, Central South University, Changsha, Hunan, China;, Mathews L; Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA;, Koehn BH; Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN;, Dwyer GK; Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA;, Lott JM; Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA;, Uhl FM; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University Medical Center Freiburg, Albert-Ludwigs University, Freiburg, Germany;, Pfeifer D; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University Medical Center Freiburg, Albert-Ludwigs University, Freiburg, Germany;, Feser CJ; Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN;, Smith MJ; Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN;, Liu Q; Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Cardiovascular Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, China;, Zeiser R; Department of Hematology and Oncology, University Medical Center, Albert-Ludwigs University, Freiburg, Germany; and., Blazar BR; Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN;, Turnquist HR; Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Publikováno v: Blood [Blood] 2016 Jul 21; Vol. 128 (3), pp. 427-39. Date of Electronic Publication: 2016 May 24.