Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Feschotte, P."'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Transposable elements (TEs) comprise ~50% of our genome, but knowledge of how TEs affect genome evolution remains incomplete. Leveraging ENCODE4 data, we provide the most comprehensive study to date of TE contributions to the regulatory geno
Externí odkaz:
https://doaj.org/article/e54702c720d643f38dd0c835f84214b2
Autor:
Nicholas Dopkins, Bhavya Singh, Stephanie Michael, Panpan Zhang, Jez L. Marston, Tongyi Fei, Manvendra Singh, Cedric Feschotte, Nicholas Collins, Matthew L. Bendall, Douglas F. Nixon
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the human genome. Our understanding of HERVs in physiology primarily surrounds their non-coding fu
Externí odkaz:
https://doaj.org/article/b795fcd1fa0147f6a7b6d5bddd81345f
Akademický článek
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Autor:
Danielle E. Lyons, Priti Kumar, Nadia R. Roan, Patricia A. Defechereux, Cedric Feschotte, Ulrike C. Lange, Niren Murthy, Pauline Sameshima, Eric Verdin, Julie A. Ake, Matthew S. Parsons, Avindra Nath, Sara Gianella, Davey M. Smith, Esper G. Kallas, Thomas J. Villa, Richard Strange, Betty Mwesigwa, Robert L. Furler O’Brien, Douglas F. Nixon, Lishomwa C. Ndhlovu, Susana T. Valente, Melanie Ott
Publikováno v:
Viruses, Vol 15, Iss 11, p 2171 (2023)
Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound competent latent and transcriptionally active reservoir cells persevere despite antiretroviral therapy and rekindle infection due to inefficient proviral silencing. We p
Externí odkaz:
https://doaj.org/article/e4df173514554fe9824778fa69c18045
Autor:
Matt Kanke, Meaghan M. Kennedy Ng, Sean Connelly, Manvendra Singh, Matthew Schaner, Michael T. Shanahan, Elizabeth A. Wolber, Caroline Beasley, Grace Lian, Animesh Jain, Millie D. Long, Edward L. Barnes, Hans H. Herfarth, Kim L. Isaacs, Jonathon J. Hansen, Muneera Kapadia, Jose Gaston Guillem, Cedric Feschotte, Terrence S. Furey, Shehzad Z. Sheikh, Praveen Sethupathy
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 6, Pp 1717-1740 (2022)
Background & Aims: The intestinal barrier comprises a monolayer of specialized intestinal epithelial cells (IECs) that are critical in maintaining mucosal homeostasis. Dysfunction within various IEC fractions can alter intestinal permeability in a ge
Externí odkaz:
https://doaj.org/article/f26eceddd75d46159db62af17e2aa45c
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background Transposable elements are increasingly recognized as a source of cis-regulatory variation. Previous studies have revealed that transposons are often bound by transcription factors and some have been co-opted into functional enhanc
Externí odkaz:
https://doaj.org/article/4cc8eca260c442fa9395bb15efb11ddc
Akademický článek
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Akademický článek
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Autor:
Thomas A Carter, Manvendra Singh, Gabrijela Dumbović, Jason D Chobirko, John L Rinn, Cédric Feschotte
Publikováno v:
eLife, Vol 11 (2022)
The human endogenous retrovirus type-H (HERVH) family is expressed in the preimplantation embryo. A subset of these elements are specifically transcribed in pluripotent stem cells where they appear to exert regulatory activities promoting self-renewa
Externí odkaz:
https://doaj.org/article/8e4eb247256d4b97bde382a3e457328e
Autor:
Jez L. Marston, Matthew Greenig, Manvendra Singh, Matthew L. Bendall, Rodrigo R.R. Duarte, Cédric Feschotte, Luis P. Iñiguez, Douglas F. Nixon
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
SARS-CoV-2 promotes an imbalanced host response that underlies the development and severity of COVID-19. Infections with viruses are known to modulate transposable elements (TEs), which can exert downstream effects by modulating host gene expression,
Externí odkaz:
https://doaj.org/article/5f450c2df1094712aae65226d29bf52d