Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms

Autor: Pecquet, C, Papadopoulos, N, Balligand, T, Chachoua, I, Tisserand, A, Vertenoeil, G, Nédélec, A, Vertommen, D, Roy, A, Marty, C, Nivarthi, H, Defour, J-P, El-Khoury, M, Hug, E, Majoros, A, Xu, E, Zagrijtschuk, O, Fertig, TE, Marta, DS, Gisslinger, H, Gisslinger, B, Schalling, M, Casetti, I, Rumi, E, Pietra, D, Cavalloni, C, Arcaini, L, Cazzola, M, Komatsu, N, Kihara, Y, Sunami, Y, Edahiro, Y, Araki, M, Lesyk, R, Buxhofer-Ausch, V, Heibl, S, Pasquier, F, Havelange, V, Plo, I, Vainchenker, W, Kralovics, R, Constantinescu, SN

Publikováno v: Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms, Vol. 141, no. 8, p. 917-929 (2023)

Mutant calreticulin (CALR) proteins resulting from a −1/+2 frameshifting mutation of the CALR exon 9 carry a novel C-terminal amino acid sequence and drive the development of myeloproliferative neoplasms (MPNs). Mutant CALRs were shown to interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e9b8c21dd22fb6d72ded0ad3f2c03b
https://pubmed.ncbi.nlm.nih.gov/36356299

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms.

Autor: Pecquet C; Ludwig Cancer Research, Brussels, Belgium.; Université Catholique de Louvain and de Duve Institute, SIGN Unit, Brussels, Belgium., Papadopoulos N; Ludwig Cancer Research, Brussels, Belgium.; Université Catholique de Louvain and de Duve Institute, SIGN Unit, Brussels, Belgium., Balligand T; Ludwig Cancer Research, Brussels, Belgium.; Université Catholique de Louvain and de Duve Institute, SIGN Unit, Brussels, Belgium., Chachoua I; Ludwig Cancer Research, Brussels, Belgium.; Université Catholique de Louvain and de Duve Institute, SIGN Unit, Brussels, Belgium.; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey., Tisserand A; INSERM, Unité Mixte de Recherche (UMR) 1287, Gustave Roussy, Villejuif, France.; Université Paris Cité, UMR 1287, Gustave Roussy, Villejuif, France.; UMR 1287, Gustave Roussy, Villejuif, France., Vertenoeil G; Ludwig Cancer Research, Brussels, Belgium.; Université Catholique de Louvain and de Duve Institute, SIGN Unit, Brussels, Belgium., Nédélec A; Ludwig Cancer Research, Brussels, Belgium.; Université Catholique de Louvain and de Duve Institute, SIGN Unit, Brussels, Belgium., Vertommen D; Université Catholique de Louvain and de Duve Institute, SIGN Unit, Brussels, Belgium., Roy A; Ludwig Cancer Research, Brussels, Belgium.; Université Catholique de Louvain and de Duve Institute, SIGN Unit, Brussels, Belgium., Marty C; INSERM, Unité Mixte de Recherche (UMR) 1287, Gustave Roussy, Villejuif, France.; UMR 1287, Gustave Roussy, Villejuif, France.; Université Paris-Saclay, UMR 1287, Gustave Roussy, Villejuif, France., Nivarthi H; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Defour JP; Ludwig Cancer Research, Brussels, Belgium.; Université Catholique de Louvain and de Duve Institute, SIGN Unit, Brussels, Belgium., El-Khoury M; INSERM, Unité Mixte de Recherche (UMR) 1287, Gustave Roussy, Villejuif, France.; UMR 1287, Gustave Roussy, Villejuif, France.; Université Paris-Saclay, UMR 1287, Gustave Roussy, Villejuif, France., Hug E; MyeloPro Diagnostics and Research GmbH, Vienna, Austria., Majoros A; MyeloPro Diagnostics and Research GmbH, Vienna, Austria., Xu E; MyeloPro Diagnostics and Research GmbH, Vienna, Austria., Zagrijtschuk O; MyeloPro Diagnostics and Research GmbH, Vienna, Austria., Fertig TE; MyeloPro Diagnostics and Research GmbH, Vienna, Austria., Marta DS; Ultrastructural Pathology Lab and Bioimaging, Institute of Pathology Victor Babeș, Bucharest, Romania., Gisslinger H; Division of Hematology and Blood Coagulation, Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna, Vienna, Austria., Gisslinger B; Division of Hematology and Blood Coagulation, Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna, Vienna, Austria., Schalling M; Division of Hematology and Blood Coagulation, Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna, Vienna, Austria., Casetti I; Division of Hematology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy., Rumi E; Division of Hematology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy., Pietra D; Division of Hematology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy., Cavalloni C; Division of Hematology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy., Arcaini L; Division of Hematology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy., Cazzola M; Division of Hematology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy., Komatsu N; Department of Hematology, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Kihara Y; Department of Hematology, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Sunami Y; Department of Hematology, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Edahiro Y; Department of Hematology, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Araki M; Department of Transfusion Medicine and Stem Cell Regulation, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Lesyk R; Department of Biotechnology and Cell Biology, Medical College, University of Information Technology and Management in Rzeszow, Rzeszow, Poland.; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine., Buxhofer-Ausch V; Department of Internal Medicine I with Hematology, Ordensklinikum Linz Elisabethinen, Stem Cell Transplantation Hemostaseology and Medical Oncology, Linz, Austria.; Medical Faculty, Johannes Kepler University Linz, Linz, Austria., Heibl S; Department of Internal Medicine IV, Klinikum Wels-Grieskirchen, Wels, Austria., Pasquier F; INSERM, Unité Mixte de Recherche (UMR) 1287, Gustave Roussy, Villejuif, France.; Université Paris Cité, UMR 1287, Gustave Roussy, Villejuif, France.; UMR 1287, Gustave Roussy, Villejuif, France.; Department of Hematology, Gustave Roussy, Villejuif, France., Havelange V; Université Catholique de Louvain and de Duve Institute, SIGN Unit, Brussels, Belgium.; Department of Hematology, Cliniques universitaires Saint-Luc, Brussels, Belgium., Plo I; INSERM, Unité Mixte de Recherche (UMR) 1287, Gustave Roussy, Villejuif, France.; UMR 1287, Gustave Roussy, Villejuif, France.; Université Paris-Saclay, UMR 1287, Gustave Roussy, Villejuif, France., Vainchenker W; INSERM, Unité Mixte de Recherche (UMR) 1287, Gustave Roussy, Villejuif, France.; UMR 1287, Gustave Roussy, Villejuif, France.; Université Paris-Saclay, UMR 1287, Gustave Roussy, Villejuif, France., Kralovics R; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria., Constantinescu SN; Ludwig Cancer Research, Brussels, Belgium.; Université Catholique de Louvain and de Duve Institute, SIGN Unit, Brussels, Belgium.; Walloon Excellence in Life Sciences and Biotechnology, Brussels, Belgium.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom.

Publikováno v: Blood [Blood] 2023 Feb 23; Vol. 141 (8), pp. 917-929.

The atomic portrait of SARS-CoV-2 as captured by cryo-electron microscopy.

Autor: Fertig TE; Ultrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania.; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania., Chitoiu L; Ultrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania., Terinte-Balcan G; Ultrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania., Peteu VE; Ultrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania., Marta D; Ultrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania., Gherghiceanu M; Ultrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania.; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Publikováno v: Journal of cellular and molecular medicine [J Cell Mol Med] 2022 Jan; Vol. 26 (1), pp. 25-34. Date of Electronic Publication: 2021 Dec 14.

Plasma Small Extracellular Vesicles Derived miR-21-5p and miR-92a-3p as Potential Biomarkers for Hepatocellular Carcinoma Screening.

Autor: Sorop A; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, Romania.; Faculty of Biology, University of Bucharest, Bucharest, Romania., Iacob R; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, Romania.; 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.; Digestive Diseases and Liver Transplantation Center, Fundeni Clinical Institute, Bucharest, Romania., Iacob S; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, Romania.; 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.; Digestive Diseases and Liver Transplantation Center, Fundeni Clinical Institute, Bucharest, Romania., Constantinescu D; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, Romania., Chitoiu L; Ultrastructural Pathology Laboratory, Victor Babeş National Institute, Bucharest, Romania., Fertig TE; 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.; Ultrastructural Pathology Laboratory, Victor Babeş National Institute, Bucharest, Romania., Dinischiotu A; Faculty of Biology, University of Bucharest, Bucharest, Romania., Chivu-Economescu M; Faculty of Biology, University of Bucharest, Bucharest, Romania.; Department of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Bucharest, Romania., Bacalbasa N; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, Romania.; 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania., Savu L; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, Romania.; 'Titu Maiorescu' University of Medicine and Pharmacy, Bucharest, Romania., Gheorghe L; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, Romania.; 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.; Digestive Diseases and Liver Transplantation Center, Fundeni Clinical Institute, Bucharest, Romania., Dima S; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, Romania.; Digestive Diseases and Liver Transplantation Center, Fundeni Clinical Institute, Bucharest, Romania., Popescu I; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, Bucharest, Romania.; Digestive Diseases and Liver Transplantation Center, Fundeni Clinical Institute, Bucharest, Romania.; 'Titu Maiorescu' University of Medicine and Pharmacy, Bucharest, Romania.

Publikováno v: Frontiers in genetics [Front Genet] 2020 Jul 23; Vol. 11, pp. 712. Date of Electronic Publication: 2020 Jul 23 (Print Publication: 2020).

Unveiling Ga(III) phthalocyanine-a different photosensitizer in neuroblastoma cellular model.

Autor: Constantin C; Immunology Department, 'Victor Babes' National Institute of Pathology, Bucharest, Romania.; Pathology Department, 'Colentina' Clinical Hospital, Bucharest, Romania., Lupu AR; Immunology Department, 'Victor Babes' National Institute of Pathology, Bucharest, Romania., Fertig TE; The Pathology Unit, 'Victor Babes' National Institute of Pathology, Bucharest, Romania., Gherghiceanu M; The Pathology Unit, 'Victor Babes' National Institute of Pathology, Bucharest, Romania., Pop S; Molecular and Cellular Medicine Department, 'Victor Babes' National Institute of Pathology, Bucharest, Romania., Ion RM; Nanomedicine Research Group, National Institute for Research & Development in Chemistry and Petrochemistry, Bucharest, Romania., Neagu M; Immunology Department, 'Victor Babes' National Institute of Pathology, Bucharest, Romania.; Pathology Department, 'Colentina' Clinical Hospital, Bucharest, Romania.; Doctoral School, Faculty of Biology, University of Bucharest, Bucharest, Romania.

Publikováno v: Journal of cellular and molecular medicine [J Cell Mol Med] 2019 Feb; Vol. 23 (2), pp. 1086-1094. Date of Electronic Publication: 2018 Nov 19.