Data from Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors

Autor: Jaap Verweij, Johann S. deBono, Paul Workman, Ferry Eskens, Stan B. Kaye, Ian R. Judson, Begona de las Heras, Luis López Lázaro, Lyndsey Welsh, Alison Reid, Sarah Reade, Andre Planting, Paul A. Clarke, Jos Kitzen, Richard D. Baird

A dose-escalation, phase I study evaluated the safety, pharmacokinetics, pharmacogenomics, and efficacy of ES-285, a novel agent isolated from a marine mollusc, in adult cancer patients. Patients received a 24-hour i.v. infusion of ES-285 once every

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228786cb352833472f7309cb8bcd8f9c
https://doi.org/10.1158/1535-7163.c.6531548

Supplementary Fig. S1 from Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors

Autor: Jaap Verweij, Johann S. deBono, Paul Workman, Ferry Eskens, Stan B. Kaye, Ian R. Judson, Begona de las Heras, Luis López Lázaro, Lyndsey Welsh, Alison Reid, Sarah Reade, Andre Planting, Paul A. Clarke, Jos Kitzen, Richard D. Baird

Supplementary Fig. S1 from Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cdb119a0914d626552f8f01333b35f
https://doi.org/10.1158/1535-7163.22484717.v1

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial

Autor: Jony van Hilst, Thijs de Rooij, Koop Bosscha, David J Brinkman, Susan van Dieren, Marcel G Dijkgraaf, Michael F Gerhards, Ignace H de Hingh, Tom M Karsten, Daniel J Lips, Misha D Luyer, Olivier R Busch, Sebastiaan Festen, Marc G Besselink, Jony Van Hilst, Thijs De Rooij, Susan Van Dieren, Ignace H De Hingh, Hendrik A Marsman, Thomas M Van Gulik, Dennis A Wicherts, Wietse J Eshuis, Luna A Stibbe, Els JM Nieveen van Dijkum, Janine E Van Hooft, Paul Fockens, Hanneke W Van Laarhoven, Johanna W Wilmink, Marcel J Van de Vijver, Maarten F Bijlsma, Joanne Verheij, C Yung Nio, Krijn P Van Lienden, Geertjan Van Tienhoven, Annuska Schoorlemmer, Geert-Jan Creemers, Casper HJ Van Eijck, Bas Groot Koerkamp, Marco J Bruno, Ferry Eskens, Joost J Nuyttens, Chulja Pek, George P Van der Schelling, Tom C Seerden, Gijs A Patijn, Vincent B Nieuwenhuijs, Jan W De Groot, Bert A Bonsing, Alexander Vahrmeijer, Rutger J Swijnenburg, J Sven D Mieog, Erwin Van der Harst, Marcel Den Dulk, Steven Olde Damink, Cees HC Dejong, Ronald Van Dam, Judith MPGM De Vos, Mike SL Liem, Cees JHM Van Laarhoven, Harry Van Goor, Peter B Van den Boezem, B Marion Van der Kolk, Martijn WJ Stommel, John J Hermans, Erwin JM Van Geenen, Sandra A Radema, Lodewijk A Brosens, Joris JG Scheepers, Daphne Roos, Djamilla Boerma, Wouter Te Riele, Hjalmar C Van Santvoort, Thomas L Bollen, Fanny Wit, I Quintus Molenaar, Nadia Haj Mohammad, Maarten S Van Leeuwen, Annemarie Roele, Kees P De Jong, Vincent E De Meijer, Joost M Klaase, Geert Kazemier, Babs Zonderhuis, Freek Daams, Martijn R Meijerink, Anouk Latenstein, L Bengt Van Rijssen, Carolijn Nota, Emo Van Halsema, Eran Van Veldhuisen, Jantien Vogel, Kiki Janssen, Lianne Scholten, Lois Daamen, Marieke Walma, Marin Strijker, Mariska Prins, Maurice Zwart, Mustafa Suker, Steffi Rombouts, Timothy Mungroop, Frederique Vissers, Maarten Korrel

Publikováno v: Lancet Gastroenterology & Hepatology, 4, 3, pp. 199-207
The Lancet Gastroenterology and Hepatology, 4(3), 199-207. Elsevier Ltd
Lancet Gastroenterology & Hepatology, 4, 199-207
lancet. Gastroenterology & hepatology, 4(3), 199-207. Elsevier Limited
The Lancet Gastroenterology and Hepatology, 4(3), 199. Elsevier Limited
van Hilst, J, de Rooij, T, Bosscha, K, Brinkman, D J, van Dieren, S, Dijkgraaf, M G, Gerhards, M F, de Hingh, I H, Karsten, T M, Lips, D J, Luyer, M D, Busch, O R, Festen, S, Besselink, M G, Marsman, H A, van Gulik, T M, Wicherts, D A, Eshuis, W J, Stibbe, L A, Nieveen van Dijkum, E J M, van Hooft, J E, Fockens, P, van Laarhoven, H W, Wilmink, J W, van de Vijver, M J, Bijlsma, M F, Verheij, J, Nio, C Y, van Lienden, K P, van Tienhoven, G, Schoorlemmer, A, Creemers, G-J, van Eijck, C H J, Groot Koerkamp, B, Bruno, M J, Eskens, F, Nuyttens, J J, Pek, C, van der Schelling, G P, Seerden, T C, de Groot, J W, Swijnenburg, R J, van den Boezem, P B, van Geenen, E J M, Scheepers, J J G, Kazemier, G, Zonderhuis, B, Daams, F, Meijerink, M R, Rombouts, S, Dutch Pancreatic Cancer Group, Mungroop, T H, Vissers, F & Korrel, M 2019, ' Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial ', The Lancet Gastroenterology and Hepatology, vol. 4, no. 3, pp. 199-207 . https://doi.org/10.1016/S2468-1253(19)30004-4
The Lancet Gastroenterology and Hepatology, 4(3), 199-207. Elsevier Ltd.
The Lancet Gastroenterology and Hepatology, 4(3), 199-207. HANLEY & BELFUS-ELSEVIER INC

Item does not contain fulltext BACKGROUND: Laparoscopic pancreatoduodenectomy may improve postoperative recovery compared with open pancreatoduodenectomy. However, there are concerns that the extensive learning curve of this complex procedure could i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057f0ae7022196e8d034f27dbb18243c
https://hdl.handle.net/2066/205431