The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

Autor: Job van Riet, Harmen J. G. van de Werken, Edwin Cuppen, Ferry A. L. M. Eskens, Margot Tesselaar, Linde M. van Veenendaal, Heinz-Josef Klümpen, Marcus W. Dercksen, Gerlof D. Valk, Martijn P. Lolkema, Stefan Sleijfer, Bianca Mostert

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) display heterogeneous clinical and genetic characteristics. Here, the authors investigate the mutational landscape of 85 aNEN by whole genome sequencing and identify distinct subpopulati

Externí odkaz: https://doaj.org/article/c4e59c95fe6b477fbcc18e6c64953ba9

Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma

Autor: Krijn K. Dijkstra, José G. van den Berg, Fleur Weeber, Joris van de Haar, Arno Velds, Sovann Kaing, Dennis D. G. C. Peters, Ferry A. L. M. Eskens, Derk-Jan A. de Groot, Margot E. T. Tesselaar, Emile E. Voest

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a poorly understood disease with limited treatment options. A better understanding of this disease would greatly benefit from the availability of representative preclinical models. Here, we

Externí odkaz: https://doaj.org/article/737cc6a2352e4ea98121176d9873021f

Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension

Autor: Leni van Doorn, Wesley J. Visser, Daan C. H. van Dorst, Katrina M. Mirabito Colafella, Stijn L. W. Koolen, Anneke van Egmond- de Mik, Ingrid M. Garrelds, Dominique M. Bovée, Esther Oomen- de Hoop, Sander Bins, Ferry A. L. M. Eskens, Ewout J. Hoorn, A. H. Jan Danser, Ron H. J. Mathijssen, Jorie Versmissen

Publikováno v: British Journal of Cancer, 128(2), 354-362. Nature Publishing Group

Background: Vascular endothelial growth factor inhibitors (VEGFIs) are effective anticancer agents which often induce hypertension. VEGFI-induced hypertension is sodium-sensitive in animal studies. Therefore, the efficacy of dietary sodium restrictio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d572507affc1cf127bfcd0c0de67f2
https://doi.org/10.1038/s41416-022-02036-6

Harmonising patient-access programmes:the Dutch DRUG Access Protocol platform

Autor: Laurien J Zeverijn, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Anke A M G Pisters van Roy, Lonneke Timmers, T H Ly Tran, Jolanda E de Boer, Gijsbrecht F de Wit, Birgit S Geurts, Hans Gelderblom, Henk M W Verheul, Nicole Blijlevens, A N Machteld Wymenga, Ferry A L M Eskens, Egbert F Smit, Haiko J Bloemendal, Emile E Voest

Publikováno v: Zeverijn, L J, van Waalwijk van Doorn-Khosrovani, S B, van Roy, A A M G P, Timmers, L, Ly Tran, T H, de Boer, J E, de Wit, G F, Geurts, B S, Gelderblom, H, Verheul, H M W, Blijlevens, N, Wymenga, A N M, Eskens, F A L M, Smit, E F, Bloemendal, H J & Voest, E E 2022, ' Harmonising patient-access programmes : the Dutch DRUG Access Protocol platform ', The Lancet Oncology, vol. 23, no. 2, pp. 198-201 . https://doi.org/10.1016/S1470-2045(21)00707-5
The Lancet Oncology, 23(2), 198-201. Lancet Publishing Group
Lancet Oncology, 23, 198-201
Lancet Oncology, 23, 2, pp. 198-201

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e79f0dca3475d812d212a606ef4951
https://research.vumc.nl/en/publications/3b1be06b-d5da-4ce0-8d91-ec8744ecd5cb

CX-072 (pacmilimab), a Probody

Autor: Aung, Naing, Fiona, Thistlethwaite, Elisabeth G E, De Vries, Ferry A L M, Eskens, Nataliya, Uboha, Patrick A, Ott, Patricia, LoRusso, Javier, Garcia-Corbacho, Valentina, Boni, Johanna, Bendell, Karen A, Autio, Manreet, Randhawa, Greg, Durm, Marta, Gil-Martin, Mark, Stroh, Alison L, Hannah, Hendrik-Tobias, Arkenau, Alexander, Spira

Publikováno v: Journal for Immunotherapy of Cancer

Background Probody® therapeutics are antibody prodrugs that are activated in the tumor microenvironment by tumor-associated proteases, thereby restricting the activity to the tumor microenvironment and minimizing ‘off-tumor’ toxicity. We report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb7d36e72940b72fb8bd9aeecd968bd8
https://pubmed.ncbi.nlm.nih.gov/34301809