Impact of Phosphorylation at Various Sites on the Active Pocket of Human Ferrochelatase: Insights from Molecular Dynamics Simulations.

Autor: Guo M; School of Chemistry, IGCME, Sun Yat-sen University, Guangzhou 510006, China., Lin Y; School of Chemistry, IGCME, Sun Yat-sen University, Guangzhou 510006, China., Obi CD; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Zhao P; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA., Dailey HA; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Medlock AE; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.; Augusta University/University of Georgia Medical Partnership, Athens, GA 30602, USA., Shen Y; School of Chemistry, IGCME, Sun Yat-sen University, Guangzhou 510006, China.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 08; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 08.

Proximal ligand tunes active site structure and reactivity in bacterial L. monocytogenes coproheme ferrochelatase.

Autor: Dali A; Dipartimento di Chimica 'Ugo Schiff' (DICUS), Università di Firenze, Via della Lastruccia 3-13, I-50019 Sesto Fiorentino (FI), Italy., Sebastiani F; Dipartimento di Chimica 'Ugo Schiff' (DICUS), Università di Firenze, Via della Lastruccia 3-13, I-50019 Sesto Fiorentino (FI), Italy., Gabler T; University of Natural Resources and Life Sciences, Department of Chemistry, Institute of Biochemistry, Muthgasse 18, A-1190 Vienna, Austria., Frattini G; Instituto de Química Rosario (IQUIR, CONICET-UNR) and Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina., Moreno DM; Instituto de Química Rosario (IQUIR, CONICET-UNR) and Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina., Estrin DA; Facultad de Ciencias Exactas y Naturales, Departamento de Química Inorgánica, Analítica y Química Física, Universidad de Buenos Aires, Intendente Güiraldes, 2160 Buenos Aires, Argentina; CONICET - Universidad de Buenos Aires, Instituto de Química-Física de los Materiales, Medio Ambiente y Energía (INQUIMAE), Ciudad Universitaria, Pabellón 2, Buenos Aires, Argentina., Becucci M; Dipartimento di Chimica 'Ugo Schiff' (DICUS), Università di Firenze, Via della Lastruccia 3-13, I-50019 Sesto Fiorentino (FI), Italy. Electronic address: maurizio.becucci@unifi.it., Hofbauer S; University of Natural Resources and Life Sciences, Department of Chemistry, Institute of Biochemistry, Muthgasse 18, A-1190 Vienna, Austria. Electronic address: stefan.hofbauer@boku.ac.at., Smulevich G; Dipartimento di Chimica 'Ugo Schiff' (DICUS), Università di Firenze, Via della Lastruccia 3-13, I-50019 Sesto Fiorentino (FI), Italy; INSTM Research Unit of Firenze, via della Lastruccia 3, I-50019 Sesto Fiorentino, Italy. Electronic address: giulietta.smulevich@unifi.it.

Publikováno v: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2024 May 15; Vol. 313, pp. 124120. Date of Electronic Publication: 2024 Mar 07.

Impact of Phosphorylation at Various Sites on the Active Pocket of Human Ferrochelatase: Insights from Molecular Dynamics Simulations

Autor: Mingshan Guo, Yuhong Lin, Chibuike David Obi, Peng Zhao, Harry A. Dailey, Amy E. Medlock, Yong Shen

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 12, p 6360 (2024)

Ferrochelatase (FECH) is the terminal enzyme in human heme biosynthesis, catalyzing the insertion of ferrous iron into protoporphyrin IX (PPIX) to form protoheme IX (Heme). Phosphorylation increases the activity of FECH, and it has been confirmed tha

Externí odkaz: https://doaj.org/article/2a31f5cb09a247979e040e9cd8d1d962

Mutation in a chlorophyll-binding motif of Brassica ferrochelatase enhances both heme and chlorophyll biosynthesis.

Autor: Liu M; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Ma W; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Su X; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Zhang X; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Lu Y; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Zhang S; Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, The University of Manchester, Manchester, UK., Yan J; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Feng D; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Ma L; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Taylor A; Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, The University of Manchester, Manchester, UK., Ge Y; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Cheng Q; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Xu K; Henan Key Laboratory of Crop Molecular Breeding & Bioreactor, Key Laboratory of Plant Genetics and Molecular Breeding, Zhoukou Normal University, Zhoukou 466001, China., Wang Y; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Li N; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Gu A; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Zhang J; Henan Key Laboratory of Crop Molecular Breeding & Bioreactor, Key Laboratory of Plant Genetics and Molecular Breeding, Zhoukou Normal University, Zhoukou 466001, China., Luo S; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Xuan S; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Chen X; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China., Scrutton NS; Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, The University of Manchester, Manchester, UK., Li C; Henan Key Laboratory of Crop Molecular Breeding & Bioreactor, Key Laboratory of Plant Genetics and Molecular Breeding, Zhoukou Normal University, Zhoukou 466001, China; College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China. Electronic address: lcw@haut.edu.cn., Zhao J; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China. Electronic address: jjz1971@aliyun.com., Shen S; State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, College of Horticulture, Hebei Agricultural University, Baoding 071000, China. Electronic address: shensx@hebau.edu.cn.

Publikováno v: Cell reports [Cell Rep] 2022 Dec 06; Vol. 41 (10), pp. 111758.

Glutamate dehydrogenase combined with ferrochelatase as a biomarker of liver injury induced by antituberculosis drugs.

Autor: He B; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Cheng X; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Xiang HR; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Li Y; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Zhang QZ; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Peng WX; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Pharmacy, the Second Xiangya Hospital, Institute of Clinical Pharmacy, Central South University, Changsha, Hunan, China., Yang B; Institute of Medical Laboratory, the First Hospital of Changsha City, Changsha, Hunan, China.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2023 Oct; Vol. 89 (10), pp. 3092-3104. Date of Electronic Publication: 2023 Jun 22.