A Proteomic Approach Identified TFEB as a Key Player in the Protective Action of Novel CB2R Bitopic Ligand FD22a against the Deleterious Effects Induced by β-Amyloid in Glial Cells.

Autor: Polini B; Department of Pathology, University of Pisa, 56100 Pisa, Italy., Zallocco L; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy., Gado F; Department of Pharmaceutical Sciences, University of Milan, 20133 Milano, Italy.; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Ferrisi R; Department of Pharmaceutical Sciences, University of Milan, 20133 Milano, Italy.; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Ricardi C; Department of Pathology, University of Pisa, 56100 Pisa, Italy., Zuccarini M; Department of Medical, Oral and Biotechnological Sciences, University G. D'Annunzio of Chieti-Pescara, 66100 Chieti, Italy., Carnicelli V; Department of Pathology, University of Pisa, 56100 Pisa, Italy., Manera C; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Ronci M; Department of Medical, Oral and Biotechnological Sciences, University G. D'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.; Interuniversitary Consortium for Engineering and Medicine (COIIM), 86100 Campobasso, Italy., Lucacchini A; Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy., Zucchi R; Department of Pathology, University of Pisa, 56100 Pisa, Italy., Giusti L; School of Pharmacy, University of Camerino, 62032 Camerino, Italy., Chiellini G; Department of Pathology, University of Pisa, 56100 Pisa, Italy.

Publikováno v: Cells [Cells] 2024 May 19; Vol. 13 (10). Date of Electronic Publication: 2024 May 19.

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New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2.

Autor: Ferrisi R; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Polini B; Department of Pathology, University of Pisa, 56126 Pisa, Italy., Ricardi C; Department of Pathology, University of Pisa, 56126 Pisa, Italy., Gado F; Department of Pharmaceutical Sciences, University of Milan, 20133 Milano, Italy., Mohamed KA; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Baron G; Department of Pharmaceutical Sciences, University of Milan, 20133 Milano, Italy., Faiella S; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Poli G; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Rapposelli S; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Saccomanni G; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Aldini G; Department of Pathology, University of Pisa, 56126 Pisa, Italy., Chiellini G; Department of Pathology, University of Pisa, 56126 Pisa, Italy., Laprairie RB; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Department of Pharmacology, College of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada., Manera C; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Ortore G; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 21; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 21.

Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands.

Autor: Gado F; Department of Pharmacy, University of Pisa, Pisa 56126, Italy., Ferrisi R; Department of Pharmacy, University of Pisa, Pisa 56126, Italy., Polini B; Department of Pharmacy, University of Pisa, Pisa 56126, Italy.; Department of Pathology, University of Pisa, Pisa 56126, Italy., Mohamed KA; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon SK S7N 5E5, Canada., Ricardi C; Department of Pathology, University of Pisa, Pisa 56126, Italy., Lucarini E; Department of Neuroscience, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence 50139, Italy., Carpi S; Department of Pharmacy, University of Pisa, Pisa 56126, Italy.; NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro, Pisa 56126, Italy., Domenichini F; Department of Pharmacy, University of Pisa, Pisa 56126, Italy., Stevenson LA; Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, U.K., Rapposelli S; Department of Pharmacy, University of Pisa, Pisa 56126, Italy.; CISUP, Centre for Instrumentation Sharing Pisa University, Lungarno Pacinotti 43, Pisa 56126, Italy., Saccomanni G; Department of Pharmacy, University of Pisa, Pisa 56126, Italy., Nieri P; Department of Pharmacy, University of Pisa, Pisa 56126, Italy., Ortore G; Department of Pharmacy, University of Pisa, Pisa 56126, Italy., Pertwee RG; Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, U.K., Ghelardini C; Department of Neuroscience, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence 50139, Italy., Di Cesare Mannelli L; Department of Neuroscience, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence 50139, Italy., Chiellini G; Department of Pathology, University of Pisa, Pisa 56126, Italy.; CISUP, Centre for Instrumentation Sharing Pisa University, Lungarno Pacinotti 43, Pisa 56126, Italy., Laprairie RB; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon SK S7N 5E5, Canada.; Department of Pharmacology, College of Medicine, Dalhousie University, Halifax B3H 4R2, Nova Scotia, Canada., Manera C; Department of Pharmacy, University of Pisa, Pisa 56126, Italy.; CISUP, Centre for Instrumentation Sharing Pisa University, Lungarno Pacinotti 43, Pisa 56126, Italy.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Jul 28; Vol. 65 (14), pp. 9918-9938. Date of Electronic Publication: 2022 Jul 18.

CB1 receptor binding sites for NAM and PAM: A first approach for studying, new n‑butyl‑diphenylcarboxamides as allosteric modulators.

Autor: Gado F; Department of Pharmacy, University of Pisa, 56126 Pisa Italy., Ceni C; Department of Pharmacy, University of Pisa, 56126 Pisa Italy; Doctoral school in Life Sciences, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Ferrisi R; Department of Pharmacy, University of Pisa, 56126 Pisa Italy., Sbrana G; Department of Pharmacy, University of Pisa, 56126 Pisa Italy., Stevenson LA; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, AB25 2ZD Aberdeen, Scotland, UK., Macchia M; Department of Pharmacy, University of Pisa, 56126 Pisa Italy., Pertwee RG; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, AB25 2ZD Aberdeen, Scotland, UK., Bertini S; Department of Pharmacy, University of Pisa, 56126 Pisa Italy., Manera C; Department of Pharmacy, University of Pisa, 56126 Pisa Italy., Ortore G; Department of Pharmacy, University of Pisa, 56126 Pisa Italy.

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2022 Feb 01; Vol. 169, pp. 106088. Date of Electronic Publication: 2021 Dec 01.