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Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain

Autor: Lu, F, Zhu, J, Guo, S, Wong, BJ, Chehab, FF, Ferriero, DM, Jiang, X

Publikováno v: Pediatric research, vol 83, iss 6
Lu, F; Zhu, J; Guo, S; Wong, BJ; Chehab, FF; Ferriero, DM; et al.(2018). Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain. PEDIATRIC RESEARCH, 83(6), 1218-1227. doi: 10.1038/pr.2018.49. UCSF: Retrieved from: http://www.escholarship.org/uc/item/8mn0t30t

BackgroundMaintenance of cholesterol homeostasis is crucial for brain development. Brain cholesterol relies on de novo synthesis and is cleared primarily by conversion to 24S-hydroxycholesterol (24S-HC) with brain-specific cholesterol 24-hydroxylase

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https://escholarship.org/uc/item/8mn0t30t

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Setting research priorities to improve global newborn health and prevent stillbirths by 2025

Autor: Yoshida, S, Martines, J, Lawn, JE, Wall, S, Souza, JP, Rudan, I, Cousens, S, Aaby, P, Adam, I, Adhikari, RK, Ambalavanan, N, Arifeen, SE, Aryal, DR, Asiruddin, S, Baqui, A, Barros, AJ, Benn, CS, Bhandari, V, Bhatnagar, S, Bhattacharya, S, Bhutta, ZA, Black, RE, Blencowe, H, Bose, C, Brown, J, Bührer, C, Carlo, W, Cecatti, JG, Cheung, PY, Clark, R, Colbourn, T, Conde-Agudelo, A, Corbett, E, Czeizel, AE, Das, A, Day, LT, Deal, C, Deorari, A, Dilmen, U, English, M, Engmann, C, Esamai, F, Fall, C, Ferriero, DM, Gisore, P, Hazir, T, Higgins, RD, Homer, CS, Hoque, DE, Irgens, L, Islam, MT, de Graft-Johnson, J, Joshua, MA, Keenan, W, Khatoon, S, Kieler, H, Kramer, MS, Lackritz, EM, Lavender, T, Lawintono, L, Luhanga, R, Marsh, D, McMillan, D, McNamara, PJ, Mol, BW, Molyneux, E, Mukasa, GK, Mutabazi, M, Nacul, LC, Nakakeeto, M, Narayanan, I, Olusanya, B, Osrin, D, Paul, V, Poets, C, Reddy, UM, Santosham, M, Sayed, R, Schlabritz-Loutsevitch, NE, Singhal, N, Smith, MA, Smith, PG, Soofi, S, Spong, CY, Sultana, S, Tshefu, A, van Bel, F, Gray, LV, Waiswa, P, Wang, W, Williams, SL, Wright, L, Zaidi, A, Zhang, Y, Zhong, N, Zuniga, I, Bahl, R

In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ad551b5d8f43a4057f33a428aa683e44
https://doi.org/10.7189/jogh.06.010508

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Early postnatal docosahexaenoic acid levels and improved preterm brain development

Autor: Ferriero, Donna, Tam, EWY, Chau, V, Barkovich, AJ, Ferriero, DM, Miller, SP, Rogers, EE, Grunau, RE, Synnes, AR, Xu, D, Foong, J

Publikováno v: Ferriero, Donna; Tam, EWY; Chau, V; Barkovich, AJ; Ferriero, DM; Miller, SP; et al.(2016). Early postnatal docosahexaenoic acid levels and improved preterm brain development. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8dp183dg

© 2016 International Pediatric Research Foundation, Inc.Preterm birth has a dramatic impact on polyunsaturated fatty acid exposures for the developing brain. This study examined the association between postnatal fatty acid levels and measures of bra

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http://www.escholarship.org/uc/item/8dp183dg

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Growth factors for the treatment of ischemic brain injury (growth factor treatment)

Autor: Ferriero, Donna, Gonzalez, Fernando, Larpthaveesarp, A, Ferriero, DM, Gonzalez, FF

Publikováno v: Ferriero, Donna; Gonzalez, Fernando; Larpthaveesarp, A; Ferriero, DM; & Gonzalez, FF. (2015). Growth factors for the treatment of ischemic brain injury (growth factor treatment).. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1cf110q5

In recent years, growth factor therapy has emerged as a potential treatment for ischemic brain injury. The efficacy of therapies that either directly introduce or stimulate local production of growth factors and their receptors in damaged brain tissu

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http://www.escholarship.org/uc/item/1cf110q5

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Stem cells for neonatal stroke- The future is here

Autor: Ferriero, Donna, van, CTJ, Gonzalez, F, Vexler, ZS, Ferriero, DM

Publikováno v: Ferriero, Donna; van, CTJ; Gonzalez, F; Vexler, ZS; & Ferriero, DM. (2014). Stem cells for neonatal stroke-The future is here. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7t66h7mv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e0996db4e984246eab03886e88ddc571
http://www.escholarship.org/uc/item/7t66h7mv

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Hypoxic preconditioning protection is eliminated in HIF-1 αknockout mice subjected to neonatal hypoxia ischemia

Autor: Ferriero, Donna, Ann, R, Lee, CL, Jiang, X, Knox, RN, Ferriero, DM

Publikováno v: Ferriero, Donna; Ann, R; Lee, CL; Jiang, X; Knox, RN; & Ferriero, DM. (2014). Hypoxic preconditioning protection is eliminated in HIF-1 αknockout mice subjected to neonatal hypoxia ischemia. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1mb452jz

Background:Hypoxic preconditioning (HPc) protects the neonatal brain in the setting of hypoxia-ischemia (HI). The mechanisms of protection may depend on activation of hypoxia-inducible factor (HIF-1). This study sought to clarify the role of HIF-1 af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::9c1fd22528b68d4c5fe04e291341f1e4
http://www.escholarship.org/uc/item/1mb452jz

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Perinatal cerebellar injury in human and animal models

Autor: Ferriero, Donna, Biran, V, Verney, C, Ferriero, DM

Publikováno v: Ferriero, Donna; Biran, V; Verney, C; & Ferriero, DM. (2012). Perinatal cerebellar injury in human and animal models. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8th0n9vt

Cerebellar injury is increasingly recognized through advanced neonatal brain imaging as a complication of premature birth. Survivors of preterm birth demonstrate a constellation of long-term neurodevelopmental deficits, many of which are potentially

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http://www.escholarship.org/uc/item/8th0n9vt

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