Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Ferreiro, Diego"'
Protein folding and evolution are intimately linked phenomena. Here, we revisit the concept of exons as potential protein folding modules across 38 abundant and conserved protein families. Taking advantage of genomic exon-intron organization and exte
Externí odkaz:
http://arxiv.org/abs/2401.02371
We propose that spontaneous folding and molecular evolution of biopolymers are two universal aspects that must concur for life to happen. These aspects are fundamentally related to the chemical composition of biopolymers and crucially depend on the s
Externí odkaz:
http://arxiv.org/abs/2310.00067
We propose an application of molecular information theory to analyze the folding of single domain proteins. We analyze results from various areas of protein science, such as sequence-based potentials, reduced amino acid alphabets, backbone configurat
Externí odkaz:
http://arxiv.org/abs/2206.14706
Autor:
Galpern, Ezequiel A., Marchi, Jacopo, Mora, Thierry, Walczak, Aleksandra M., Ferreiro, Diego U.
Repeat proteins are made with tandem copies of similar amino acid stretches that fold into elongated architectures. Due to their symmetry, these proteins constitute excellent model systems to investigate how evolution relates to structure, folding an
Externí odkaz:
http://arxiv.org/abs/2202.12223
We propose a mesoscale model structure for the coronavirus nucleocapsid, assembled from the high resolution structures of the basic building blocks of the N-protein, CryoEM imaging and mathematical constraints for an overall quasi-spherical particle.
Externí odkaz:
http://arxiv.org/abs/2005.12165
Publikováno v:
A&A 629, A50 (2019)
In order to study the slope and strength of the non-stellar continuum, we analyzed a sample of nearby Narrow Line Seyfert 1 (NLS1). Also, we re-examined the location of NLS1 galaxies on the M $-$ $\sigma$ relation using the stellar velocity dispersio
Externí odkaz:
http://arxiv.org/abs/1906.07909
Autor:
Marchi, Jacopo, Galpern, Ezequiel A., Espada, Rocio, Ferreiro, Diego U., Walczak, Aleksandra M., Mora, Thierry
Publikováno v:
PLoS Comput Biol 15(8): e1007282 (2019)
The coding space of protein sequences is shaped by evolutionary constraints set by requirements of function and stability. We show that the coding space of a given protein family--the total number of sequences in that family--can be estimated using m
Externí odkaz:
http://arxiv.org/abs/1905.04493
We present a detailed heuristic method to quantify the degree of local energetic frustration manifested by protein molecules. Current applications are realized in computational experiments where a protein structure is visualized highlighting the ener
Externí odkaz:
http://arxiv.org/abs/1812.05965
Akademický článek
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Autor:
Turjanski, Pablo, Ferreiro, Diego U.
All known terrestrial proteins are coded as continuous strings of ~20 amino acids. The patterns formed by the repetitions of elements in groups of finite sequences describes the natural architectures of protein families. We present a method to search
Externí odkaz:
http://arxiv.org/abs/1807.10394