Selective inhibition of HDAC6 by N-acylhydrazone derivative reduces the proliferation and induces senescence in carcinoma hepatocellular cells.

Autor: Ferreira-Silva GÁ; Institute of Biomedical Sciences, Federal University of Alfenas, MG 37130-001, Brazil., Rodrigues DA; Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, CCS, Rio de Janeiro, RJ, Brazil., Pressete CG; Institute of Biomedical Sciences, Federal University of Alfenas, MG 37130-001, Brazil., Caixeta ES; Institute of Biomedical Sciences, Federal University of Alfenas, MG 37130-001, Brazil., Gamero AMC; Human Genetics Laboratory, Institute of Natural Science, Federal University of Alfenas, zip-code 37130-001, Alfenas, MG, Brazil., Miyazawa M; School of Dentistry, Federal University of Alfenas, 37130-001 MG, Brazil., Hanemann JAC; School of Dentistry, Federal University of Alfenas, 37130-001 MG, Brazil., Fraga CAM; Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, CCS, Rio de Janeiro, RJ, Brazil., Aissa AF; Institute of Biomedical Sciences, Federal University of Alfenas, MG 37130-001, Brazil. Electronic address: aissa@unifesp.br., Ionta M; Institute of Biomedical Sciences, Federal University of Alfenas, MG 37130-001, Brazil. Electronic address: marisa.ionta@unifal-mg.edu.br.

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2024 Aug; Vol. 99, pp. 105884. Date of Electronic Publication: 2024 Jun 28.

Synthesis and Structure-Activity Relationship Studies of Novel Aryl Sulfonamides and Their Activity against Human Breast Cancer Cell Lines.

Autor: Azevedo-Barbosa H; LQFar - Laboratory of Pharmaceutical Chemistry Research, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, 700, Gabriel Monteiro da Silva, 37130-001, Alfenas, MG, Brazil., Ferreira-Silva GÁ; LABAInt - Laboratory of Integrative Animal Biology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Brazil., do Vale BP; LQFar - Laboratory of Pharmaceutical Chemistry Research, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, 700, Gabriel Monteiro da Silva, 37130-001, Alfenas, MG, Brazil., Hawkes JA; LQFar - Laboratory of Pharmaceutical Chemistry Research, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, 700, Gabriel Monteiro da Silva, 37130-001, Alfenas, MG, Brazil., Ionta M; LABAInt - Laboratory of Integrative Animal Biology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Brazil., Carvalho DT; LQFar - Laboratory of Pharmaceutical Chemistry Research, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, 700, Gabriel Monteiro da Silva, 37130-001, Alfenas, MG, Brazil.

Publikováno v: Chemistry & biodiversity [Chem Biodivers] 2022 Dec; Vol. 19 (12), pp. e202200831. Date of Electronic Publication: 2022 Nov 15.

Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E down-regulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell line.

Autor: Azevedo-Barbosa H; LQFar - Laboratory of Research in Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, 37130-001 Alfenas, MG, Brazil., Ferreira-Silva GÁ; LabaInt - Laboratory of Integrative Animal Biology, Institute of Biomedical Sciences, Federal University of Alfenas, 37130-001 Alfenas, MG, Brazil., Silva CF; LQFar - Laboratory of Research in Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, 37130-001 Alfenas, MG, Brazil., de Souza TB; School of Pharmacy, Federal University of Ouro Preto, 35400-000 Ouro Preto, MG, Brazil., Dias DF; LFQM - Laboratory of Phytochemistry and Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, 37130-001 Alfenas, MG, Brazil., de Paula ACC; Department of Pharmaceutical Sciences, College of Pharmacy, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil., Ionta M; LabaInt - Laboratory of Integrative Animal Biology, Institute of Biomedical Sciences, Federal University of Alfenas, 37130-001 Alfenas, MG, Brazil. Electronic address: marisa.ionta@unifal-mg.edu.br., Carvalho DT; LQFar - Laboratory of Research in Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, 37130-001 Alfenas, MG, Brazil. Electronic address: diogo.carvalho@unifal-mg.edu.br.

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2019 Sep; Vol. 59, pp. 150-160. Date of Electronic Publication: 2019 Apr 22.

Pro-apoptotic activity of ruthenium 1-methylimidazole complex on non-small cell lung cancer.

Autor: Dias JSM; Instituto de Química, Universidade Federal de Alfenas, CEP 37130-001 Alfenas, MG, Brazil., Silva HVR; Instituto de Química, Universidade Federal de Alfenas, CEP 37130-001 Alfenas, MG, Brazil., Ferreira-Silva GÁ; Departamento de Ciências Biomédicas, Universidade Federal de Alfenas, CEP 37130-001, Alfenas, MG, Brazil., Ionta M; Departamento de Ciências Biomédicas, Universidade Federal de Alfenas, CEP 37130-001, Alfenas, MG, Brazil., Corrêa CC; Departamento de Química, ICE Universidade Federal de Juiz de Fora, CEP 36036-900 Juiz de Fora, MG, Brazil., Almeida F; Instituto de Ciências Biomédicas - icb4, Universidade de São Paulo, CEP 05508-900 São Paulo, SP, Brazil., Colina-Vegas L; Departamento de Química, Universidade Federal de São Carlos, CEP 13565-905 São Carlos, SP, Brazil., Barbosa MIF; Instituto de Química, Universidade Federal de Alfenas, CEP 37130-001 Alfenas, MG, Brazil. Electronic address: mariliaifrazaob@gmail.com., Doriguetto AC; Instituto de Química, Universidade Federal de Alfenas, CEP 37130-001 Alfenas, MG, Brazil. Electronic address: doriguetto@unifal-mg.edu.br.

Publikováno v: Journal of inorganic biochemistry [J Inorg Biochem] 2018 Oct; Vol. 187, pp. 1-13. Date of Electronic Publication: 2018 Jul 04.

Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.

Autor: Dias Viegas FP; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., de Freitas Silva M; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Divino da Rocha M; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Castelli MR; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Riquiel MM; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Machado RP; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Vaz SM; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Simões de Lima LM; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Mancini KC; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Marques de Oliveira PC; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Morais ÉP; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Gontijo VS; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., da Silva FMR; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ 21941-902, Brazil., D'Alincourt da Fonseca Peçanha D; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ 21941-902, Brazil., Castro NG; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ 21941-902, Brazil., Neves GA; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ 21941-902, Brazil., Giusti-Paiva A; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil., Vilela FC; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil., Orlandi L; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil., Camps I; Institute of Exact Sciences, Federal University of Alfenas, MG 37130-000, Brazil., Veloso MP; Faculty of Pharmacy, Federal University of Alfenas, MG 37130-000, Brazil., Leomil Coelho LF; Laboratory of Vaccines, Institute of Biomedical Sciences, Federal University of Alfenas, MG 37130-000, Brazil., Ionta M; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil., Ferreira-Silva GÁ; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil., Pereira RM; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil., Dardenne LE; National Laboratory of Computational Sciences, Petrópolis, RJ 25651-075, Brazil., Guedes IA; National Laboratory of Computational Sciences, Petrópolis, RJ 25651-075, Brazil., de Oliveira Carneiro Junior W; Institute of Biological Sciences, Federal University of Minas Gerais, MG 31270-901, Brazil., Quaglio Bellozi PM; Institute of Biological Sciences, Federal University of Minas Gerais, MG 31270-901, Brazil., Pinheiro de Oliveira AC; Institute of Biological Sciences, Federal University of Minas Gerais, MG 31270-901, Brazil., Ferreira FF; Centre of Natural and Human Sciences, Federal University of ABC, Santo André, SP 09210-580, Brazil., Pruccoli L; Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Rimini 47921, Italy., Tarozzi A; Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Rimini 47921, Italy., Viegas C Jr; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil. Electronic address: cvjviegas@gmail.com.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2018 Mar 10; Vol. 147, pp. 48-65. Date of Electronic Publication: 2018 Jan 31.