Translatability of preclinical to early clinical tolerable and pharmacologically active dose ranges for central nervous system active drugs

Autor: Ferreira, Guilherme S, Dijkstra, Francis M, Veening-Griffioen, Désirée H, Boon, Wouter P C, Schellekens, Huub, Moors, Ellen H M, van Meer, Peter J K, Stuurman, Frederik E, van Gerven, Joop M A, Afd Pharmaceutics, Innovation and Sustainability, Innovation Studies, Dep Farmaceutische wetenschappen

Publikováno v: Translational Psychiatry, 13(1). Nature Publishing Group

The primary purpose of this study was to assess the translatability of preclinical to early clinical tolerable and pharmacologically active dose ranges for central nervous system (CNS) active drugs. As a part of this, IBs were reviewed on reporting q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2150d8d082e72552d1c0c258824ef2
https://doi.org/10.1038/s41398-023-02353-1

Pathways in the Drug Development for Alzheimer’s Disease (1906-2016): A Bibliometric Study

Autor: Schilder, Isabel PA, Veening-Griffioen, Désirée H, Ferreira, Guilherme S, Meer, Peter JK Van, Wied, Christine C Gispen-de, Schellekens, Huub, Boon, Wouter PC, Moors, Ellen HM, Afd Pharmaceutics, Innovation and Sustainability, Innovation Studies, Pharmaceutics

Publikováno v: Journal of Scientometric Research, 9(3), 277

Investments in drug development for Alzheimer's disease (AD) have not led to the availability of a treatment to cure or halt the progression of the disease. This study aimed to provide insights into the current lack of an effective therapy against AD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31c1540990ebd5466dc3f18ff5ebd14
https://doi.org/10.5530/jscires.9.3.35

Levelling the Translational Gap for Animal to Human Efficacy Data

Autor: Ferreira, Guilherme S., Veening-Griffioen, Désirée H., Boon, Wouter P. C., Moors, Ellen H. M., van Meer, Peter J. K., Afd Pharmaceutics, Innovation and Sustainability, Innovation Studies, Pharmaceutics

Publikováno v: Animals : an Open Access Journal from MDPI
Animals, 10(7). Multidisciplinary Digital Publishing Institute (MDPI)
Animals, Vol 10, Iss 1199, p 1199 (2020)

Simple Summary The value of animal research has been increasingly debated, owing to high failure rates in drug development. A potential contributor to this situation is the lack of predictivity of animal models of disease. Until recently, most initia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59dc7ead95e01e72d1d5413a0da2804
http://europepmc.org/articles/PMC7401509

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