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Toxicogenetic assessment of a pre-workout supplement: In vitro mutagenicity, cytotoxicity, genotoxicity and glutathione determination in liver cell lines and in silico ADMET approaches.

Autor: Carrão Dantas EK; Laboratory of Environmental Mutagenicity, Department of Biophysics and Biometry, Rio de Janeiro State University, UERJ, Rio de Janeiro, Brazil; Department of Genetics and Molecular Biology, Federal University of Rio de Janeiro State, UNIRIO, Rio de Janeiro, Brazil. Electronic address: eduardokennedy10@gmail.com., Araújo-Lima CF; Laboratory of Environmental Mutagenicity, Department of Biophysics and Biometry, Rio de Janeiro State University, UERJ, Rio de Janeiro, Brazil; Department of Genetics and Molecular Biology, Federal University of Rio de Janeiro State, UNIRIO, Rio de Janeiro, Brazil. Electronic address: biomed.carlos@gmail.com., Ferreira CLS; Laboratory of Environmental Mutagenicity, Department of Biophysics and Biometry, Rio de Janeiro State University, UERJ, Rio de Janeiro, Brazil; Department of Genetics and Molecular Biology, Federal University of Rio de Janeiro State, UNIRIO, Rio de Janeiro, Brazil. Electronic address: carolinelsferreira@gmail.com., Goldstein ADC; Laboratory of Environmental Mutagenicity, Department of Biophysics and Biometry, Rio de Janeiro State University, UERJ, Rio de Janeiro, Brazil; Department of Genetics and Molecular Biology, Federal University of Rio de Janeiro State, UNIRIO, Rio de Janeiro, Brazil. Electronic address: alanacgold@gmail.com., Aiub CAF; Department of Genetics and Molecular Biology, Federal University of Rio de Janeiro State, UNIRIO, Rio de Janeiro, Brazil. Electronic address: aiub.claudia@gmail.com., Coelho MGP; Department of Biochemistry, Rio de Janeiro State University, UERJ, Rio de Janeiro, Brazil. Electronic address: marsengpc@gmail.com., Felzenszwalb I; Laboratory of Environmental Mutagenicity, Department of Biophysics and Biometry, Rio de Janeiro State University, UERJ, Rio de Janeiro, Brazil. Electronic address: uerj.felzen@gmail.com.

Publikováno v: Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2022 Jul-Aug; Vol. 879-880, pp. 503517. Date of Electronic Publication: 2022 Jun 22.