Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Feroze, Ujjainwalla"'
Autor:
Qiaoling Deng, Feroze Ujjainwalla, F. Anthony Romero, Jenna L. Terebetski, Jerry Di Salvo, Ying Li, Dorina Trusca, Ming Wang, Nicholas B. Hastings, Remond Moningka, Vincent Tong, Zhiqiang Guo, Richard G. Ball
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(23)
Here, we report the discovery of a new class of NPBWR1 antagonists identified from a fragment-based screen. Compound 1 (cAMP IC50 = 250 µM; LE = 0.29) emerged as an initial hit. Further optimization of 1 by SAR-by-catalogue and chemical modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e4a6a9cbe7d66ea64b2f90c58c7963
https://pubmed.ncbi.nlm.nih.gov/32898693
https://pubmed.ncbi.nlm.nih.gov/32898693
Autor:
Jiaqiang Cai, Bimjhana Bishwokarma, Dennis Leung, William J. Morris, Feroze Ujjainwalla, Candice Alleyne, Xiaoxing Du, Vincent J. Colandrea, Jennifer Piesvaux, Jianwu Bai, Liming Yang, Carla Alpert, Joseph M. Metzger, Vincenzo Pucci, Xiaofang Li, Jeffrey J. Hale, Dominique Stickens, Weiguo Quan, Byron G. DuBois, Rongqiang Liu, Mark Zielstorff, Chi-Sung Chiu, Christopher Joseph Sinz, Mangeng Cheng, Kallol Ray, Liping Wang, Ping Liu, Stella H. Vincent, Alejandro Crespo
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1193-1198
[Image: see text] We report herein the design and synthesis of a series of orally active, liver-targeted hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitors for the treatment of anemia. In order to mitigate the concerns for potential sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76215d13beffa00c0fc7a79f728fdec
https://doi.org/10.1021/acsmedchemlett.8b00274
https://doi.org/10.1021/acsmedchemlett.8b00274
Autor:
Weiguo Liu, Ramzi F. Sweis, Feroze Ujjainwalla, Remond Moningka, F. Anthony Romero, Yi Zang, Paul E. Finke, Zahid Hussain, Karen H. Dingley, Michael A. Plotkin, Andrew D. Howard, Jin Shang, Beth Ann Murphy, Jianming Bao, Gino Salituro, Harold B. Wood, Joseph L. Duffy
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1088-1093
[Image: see text] A series of structurally diverse azaspirodecanone and spirooxazolidinone analogues were designed and synthesized as potent and selective somatostatin receptor subtype 5 (SSTR5) antagonists. Four optimized compounds each representing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3022cb6ad0fbfbeb2a2945fb1685174d
https://doi.org/10.1021/acsmedchemlett.8b00306
https://doi.org/10.1021/acsmedchemlett.8b00306
Autor:
Joe Clemas, Jerry Andrew Taylor, Feroze Ujjainwalla, Jim Tata, Doris F. Cully, Tom Wisniewski, Wei Tang, Charlene Bopp, Clare London, Andreas Verras, Scott B. Hoyt, Andrea Sok, Elaine Tung, Douglas J. MacNeil, Gaochao Zhou, Amjad Ali, Qing Chen, Gino Salituro, Yusheng Xiong, Daniel R. McMasters, Mary Struthers, Ning Ren, Ruth A. Duffy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2384-2388
We report the discovery and hit-to-lead optimization of a structurally novel indazole series of CYP11B2 inhibitors. Benchmark compound 34 from this series displays potent inhibition of CYP11B2, high selectivity versus related steroidal and hepatic CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f9a114775b2eff2c4ce3ec96aa4668
https://doi.org/10.1016/j.bmcl.2017.04.021
https://doi.org/10.1016/j.bmcl.2017.04.021
Autor:
Melissa Kirkland, M A Powles, Francisco Velazquez, Eric R. Ashley, Nengxue Wang, Shah Unmesh G, Feroze Ujjainwalla, Taro E. Akiyama, Eric J. Gilbert, Charles Lee Jayne, Michele Pachanski, Dan Zhou, Scott D. Edmondson, Jerry Di Salvo, Andreas Verras, Maria Madeira, Takao Suzuki, Srikanth Venkatraman, Quang Truong, Wu Yin, Gregory L. Adams, Shouwu Miao
Publikováno v:
ACS Medicinal Chemistry Letters. 8:96-101
GPR120 (FFAR4) is a fatty acid sensing G protein coupled receptor (GPCR) that has been identified as a target for possible treatment of type 2 diabetes. A selective activator of GPR120 containing a chromane scaffold has been designed, synthesized, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5c4bd187bc901f79299111d7c132c57
https://doi.org/10.1021/acsmedchemlett.6b00394
https://doi.org/10.1021/acsmedchemlett.6b00394
Autor:
Dann L. Parker, Randal M. Bugianesi, Birgit T. Priest, Feroze Ujjainwalla, Edward C. Sherer, Stanley Mitelman, Sharon Tong, Matthew Lombardo, William K. Hagmann, Ravi P. Nargund, Melissa Costa, Christopher Joseph Sinz, Anka G. Ehrhardt, Scott D. Edmondson, Ravi Kurukulasuriya, Xiaofang Li, Karen H. Dingley, Kate Bender, Kevin S. Ratliff, Jonathan E. Wilson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2947-2951
A novel series of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists are described. The series was designed to address the suboptimal PK (pharmacokinetic) and off-target profile of a class of N-aryl-benzo-[1,4]-oxazepine-4-carboxamides, represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f4fd9aaf407b2d77d08816feb7cb20
https://doi.org/10.1016/j.bmcl.2016.04.018
https://doi.org/10.1016/j.bmcl.2016.04.018
Autor:
Feroze Ujjainwalla, Andrew M. K. Pennell, Carmen Escolano, William B. Motherwell, Santiago Vázquez, Maria Lucília E.N. da Mata
Publikováno v:
Tetrahedron. 71:6701-6719
A variety of functionalised biaryls and heterobiaryls are prepared by intramolecular free radical [1,5]-ipso-substitution using sulfonamide and sulfonate derived tethering chains. The overall efficiency of the process is determined by appropriately p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f89dac5782224d001dd4cd0db835f6f8
https://doi.org/10.1016/j.tet.2015.07.048
https://doi.org/10.1016/j.tet.2015.07.048
Autor:
Matthew Lombardo, Eric N. Johnson, John Cummings, Jerry Di Salvo, Thomas Roussel, James R. Tata, Melissa Kirkland, Michael A. Plotkin, Christopher Joseph Sinz, Feroze Ujjainwalla, Dennis Leung, Dorina Trusca, Joel Mane, Taro E. Akiyama, Alejandro Crespo, Mary Ann Powles, Kate Bender, Michael F.A. Finley, Joanna Pols, Candice Alleyne, Michele Pachanski, Andrew D. Howard, Wayne M. Geissler, Ying Lei, Bahanu Habulihaz, Victor N. Uebele, Clare London, Maria Madeira
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15bdf4d7ae8e579647d40689c42f33e
https://pubmed.ncbi.nlm.nih.gov/27815121
https://pubmed.ncbi.nlm.nih.gov/27815121
Autor:
Feroze Ujjainwalla, Charlene Bopp, Carrie Ann Shipley, Yusheng Xiong, Mary Struthers, Bindhu V. Karanam, Clare London, Gaochao Zhou, Ning Ren, Andreas Verras, Andrea Sok, Amjad Ali, Qing Chen, Doris F. Cully, Joseph Clemas, Jack Gibson, James R. Tata, Daniel R. McMasters, Ying Li, Whitney Lane Petrilli, Scott B. Hoyt, Elaine Tung, Ian Knemeyer, Ruth A. Duffy, Wei Tang, Thomas Wisniewski, Douglas J. MacNeil, Gino Salituro
Publikováno v:
ACS medicinal chemistry letters. 8(1)
Herein we report the discovery and hit-to-lead optimization of a series of spirocyclic piperidine aldosterone synthase (CYP11B2) inhibitors. Compounds from this series display potent CYP11B2 inhibition, good selectivity versus related CYP enzymes, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd54739c1d66c5903e38d15b799bee69
https://pubmed.ncbi.nlm.nih.gov/28105288
https://pubmed.ncbi.nlm.nih.gov/28105288
Autor:
John S. Debenham, Dann L. Parker, Birgit T. Priest, Ravi P. Nargund, Feroze Ujjainwalla, Randal M. Bugianesi, Michele Pachanski, Liangqin Guo, William K. Hagmann, George J. Eiermann, Yi Zang, Ramzi F. Sweis, Andrew D. Howard, Jenna L. Terebetski, Melissa Kirkland, Yue Feng, Gino Salituro, Derun Li, Christopher Joseph Sinz, Stan Mitelman, Maria E. Trujillo, Scott D. Edmondson, Karen H. Dingley, Jin Shang, Nicole Buist, Xiaofang Li, Weiguo Liu, Mary Ann Powles, Terri M. Kelly, Edward C. Sherer
GPR142 has been identified as a potential glucose-stimulated insulin secretion (GSIS) target for the treatment of type 2 diabetes mellitus (T2DM). A class of triazole GPR142 agonists was discovered through a high throughput screen. The lead compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05666abdc0e69d7961b4edf099a12f0b
https://europepmc.org/articles/PMC5150677/
https://europepmc.org/articles/PMC5150677/
