Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes

Autor: Rajarshi Ghosh, Kevin Colon-Negron, Feroz R. Papa

Publikováno v: Molecular Metabolism, Vol 27, Iss , Pp S60-S68 (2019)

Background: Myriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) — a condition referred to as “ER stress” — activate intracellular signaling pathways termed t

Externí odkaz: https://doaj.org/article/49eb666b9c5d41aaa1bce2669a388e64

Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.

Autor: Maike Thamsen, Rajarshi Ghosh, Vincent C Auyeung, Alexis Brumwell, Harold A Chapman, Bradley J Backes, Gayani Perara, Dustin J Maly, Dean Sheppard, Feroz R Papa

Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0209824 (2019)

Endoplasmic reticulum stress (ER stress) has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease of progressive fibrosis and respiratory failure. ER stress activates a signaling pathway called the unfolded protein re

Externí odkaz: https://doaj.org/article/72a21c8a3c184effb4aa0c1bf69d7717

Figure S5 from Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival

Autor: Scott A. Oakes, Feroz R. Papa, Bradley J. Backes, Dustin J. Maly, Grace E. Kim, Annie Hiniker, Rachel E. Warren, Rosa Meza-Acevedo, Micah J. Gliedt, Justin Peng, Rajarshi Ghosh, Maike Thamsen, Jenny Y. Qi, Paul C. Moore

KIRA8 and GSK-PKI induce distinct apoptotic markers in INS1 tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f01540573145c2470ed78f2d3839477
https://doi.org/10.1158/0008-5472.22422192.v1

Data from Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival

Autor: Scott A. Oakes, Feroz R. Papa, Bradley J. Backes, Dustin J. Maly, Grace E. Kim, Annie Hiniker, Rachel E. Warren, Rosa Meza-Acevedo, Micah J. Gliedt, Justin Peng, Rajarshi Ghosh, Maike Thamsen, Jenny Y. Qi, Paul C. Moore

Master regulators of the unfolded protein response (UPR), IRE1α and PERK, promote adaptation or apoptosis depending on the level of endoplasmic reticulum (ER) stress. Although the UPR is activated in many cancers, its effects on tumor growth remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::679562d6e2c3b557add888ab01883cce
https://doi.org/10.1158/0008-5472.c.6511146.v1

Nicotinic acetylcholine receptor signaling regulates inositol‐requiring enzyme 1α activation to protect β‐cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress

Autor: Hidefumi Inaba, Hiroshi Iwakura, Hiroyuki Ariyasu, Takashi Akamizu, Shohei Kishimoto, Hiroto Furuta, Shuhei Morita, Shinsuke Uraki, Tatsuya Ishibashi, Yasushi Furukawa, Ken Takeshima, Feroz R. Papa, Masahiro Nishi

Publikováno v: Journal of Diabetes Investigation, Vol 11, Iss 4, Pp 801-813 (2020)
Journal of Diabetes Investigation
Journal of diabetes investigation, vol 11, iss 4

Aims/Introduction Under irremediable endoplasmic reticulum (ER) stress, hyperactivated inositol‐requiring enzyme 1α (IRE1α) triggers the terminal unfolded protein response (T‐UPR), causing crucial cell dysfunction and apoptosis. We hypothesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501dbdaa109d053a26147fad3c079d84
https://doaj.org/article/ff431383310046a381016cae5c800dcb