Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1

Autor: Rabin, S., Miliani de Marval, P. L., Rodriguez-Puebla, M., Fero, M. L., Chien, W.-M., Macias, E., Orthel, J., Garrison, K.

Loss of the cyclin-dependent kinase inhibitor p27Kip1 leads to an overall increase in animal growth, pituitary tumors, and hyperplasia of hematopoietic organs, yet it is unknown whether all cells function autonomously in response to p27Kip1 activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eef11a7f0e01b9978f6fdbcf82906b36

Inducible expression and cytogenetic effects of the EcoRI restriction endonuclease in Chinese hamster ovary cells

Autor: Morgan, W F, Fero, M L, Land, M C, Winegar, R A

Publikováno v: Molecular and Cellular Biology; October 1988, Vol. 8 Issue: 10 p4204-4211, 8p

Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1).

Autor: Hiromura K; Department of Medicine, Division of Nephrology, University of Washington School of Medicine, Seattle, Washington 98195-6521, USA., Pippin JW, Fero ML, Roberts JM, Shankland SJ

Publikováno v: The Journal of clinical investigation [J Clin Invest] 1999 Mar; Vol. 103 (5), pp. 597-604.

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.

Autor: Fero ML; Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Randel E, Gurley KE, Roberts JM, Kemp CJ

Publikováno v: Nature [Nature] 1998 Nov 12; Vol. 396 (6707), pp. 177-80.

p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation.

Autor: Durand B; Medical Research Council Developmental Neurobiology Programme, MRC Laboratory for Molecular Cell Biology, Biology Department, University College London, London, WC1E 6BT, UK. bdurand@bcm.tmc.edu, Fero ML, Roberts JM, Raff MC

Publikováno v: Current biology : CB [Curr Biol] 1998 Apr 09; Vol. 8 (8), pp. 431-40.