Colombian Scorpion Centruroides margaritatus: Purification and Characterization of a Gamma Potassium Toxin with Full-Block Activity on the hERG1 Channel

Autor: Nina Pastor, Edson Norberto Carcamo-Noriega, Fernando Zamudio-Zuñiga, Lourival D. Possani, Santiago Castaño, José Beltrán-Vidal, Jimmy Alexander Guerrero-Vargas, Rita Restano-Cassulini

Publikováno v: Toxins, Vol 13, Iss 407, p 407 (2021)
Toxins
Volume 13
Issue 6

The Colombian scorpion Centruroides margaritatus produces a venom considered of low toxicity. Nevertheless, there are known cases of envenomation resulting in cardiovascular disorders, probably due to venom components that target ion channels. Among

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2b1e710b501e5f01b551c9afa0f012
https://www.mdpi.com/2072-6651/13/6/407

Antiseizure potential of peptides from the venom of social wasp Chartergellus communis against chemically-induced seizures

Autor: Maria Varela Torres Quintanilha, Márcia Renata Mortari, Adolfo Carlos Barros de Souza, Fernando Zamudio-Zuñiga, Kamila Soares Lopes, Lourival D. Possani

Publikováno v: Toxicon : official journal of the International Society on Toxinology. 194

Epilepsy is one of the most common neurological diseases in the world. The objective of this research was to investigate a new peptide from the venom of the social wasp Chartergellus communis useful to the study or pharmacotherapy of epilepsy. The wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33af14f9b0f5257c3ac0403e93e5729
https://pubmed.ncbi.nlm.nih.gov/33610635

Structural and functional characterization of toxic peptides purified from the venom of the Colombian scorpion Tityus macrochirus

Autor: Fernando Zamudio Zuñiga, Edmundo González Santillán, Edgar A. Reyes-Montaño, Edson Norberto Carcamo-Noriega, Lourival D. Possani, Clara Andrea Rincón-Cortés, Nohora Angélica Vega Castro, Timoteo Olamendi-Portugal

Publikováno v: Repositorio Institucional UDCA
Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
instacron:Universidad de Ciencias Aplicadas y Ambientales U.D.C.A

The soluble venom of the scorpion Tityus macrochirus was separated by chromatographic procedures and three homogeneous peptides were obtained and their primary structures were determined. They were called: Tma1-Tma3, from the abbreviated name of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb584e34757c349dd103cd72aceb9ab
https://pubmed.ncbi.nlm.nih.gov/31402191

Spodoptera frugiperda (J. E. Smith) Aminopeptidase N1 Is a Functional Receptor of the Bacillus thuringiensis Cry1Ca Toxin

Autor: Mario Soberón, Sabino Pacheco, Ricardo Grande, Jorge Sánchez, Gabriela Flores-Ramirez, Isabel Gómez, Daniel E. Rodríguez-Chamorro, Francisco J. Portugal, Alejandra Bravo, Fernando Zamudio Zuñiga

Publikováno v: Applied and environmental microbiology. 84(17)

Bacillus thuringiensis Cry1Ca is toxic to different Spodoptera species. The aims of this work were to identify the Cry1Ca-binding proteins in S. frugiperda, to provide evidence on their participation in toxicity, and to identify the Cry1Ca amino acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14cef6bbb9138127950589ecc5bbacc
https://pubmed.ncbi.nlm.nih.gov/29959247

Isolation, chemical and functional characterization of several new K+-channel blocking peptides from the venom of the scorpion Centruroides tecomanus

Autor: Fernando Zamudio-Zuñiga, Lourival D. Possani, Baltazar Becerril, Andras Balajthy, Adam Bartok, Timoteo Olamendi-Portugal, Gyorgy Panyi

Six new peptides were isolated from the venom of the Mexican scorpion Centruroides tecomanus; their primary structures were determined and the effects on ion channels were verified by patch-clamp experiments. Four are K(+)-channel blockers of the α-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcd34b29d1ca1219dd5f5c3b66df9e8