Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Fernando Rock"'
Autor:
Marina Pajic, Vishal Kothari, Diego Chacon Fajardo, Chad L Moore, Sean Porazinski, Benjamin McLean, Eve Borbilas, Tim Machajewski, Fernando Rock, Scott M Turner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/dbc9ee3f6eb145d99efcd87f82a50b5b
Autor:
Manuel Muñoz, Vishal Kothari, Tim Machajewski, Fernando Rock, Scott M Turner, Selorm Tamakloe, Colin Magowan, Gail Lee, Darren Finkelstein, Tim Hom, Dennis Monteleone, Subramanian Karu, Erine Budi, Prerna Kotak, Shamra Martin, Katherine Jenkins, Martin Decaris
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/70486df34a3a4e7aabe10f1ca719d9a7
Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Autor:
Martin L. Decaris, Johanna R. Schaub, Chun Chen, Jacob Cha, Gail G. Lee, Megi Rexhepaj, Steve S. Ho, Vikram Rao, Megan M. Marlow, Prerna Kotak, Erine H. Budi, Lisa Hooi, Jianfeng Wu, Marina Fridlib, Shamra P. Martin, Shaoyi Huang, Ming Chen, Manuel Muñoz, Timothy F. Hom, Paul J. Wolters, Tushar J. Desai, Fernando Rock, Katerina Leftheris, David J. Morgans, Eve-Irene Lepist, Patrick Andre, Eric A. Lefebvre, Scott M. Turner
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs. Obj
Externí odkaz:
https://doaj.org/article/f75a5266ef724db48db905d69406f78e
Autor:
Thavy Long, Liliana Rojo-Arreola, Da Shi, Nelly El-Sakkary, Kurt Jarnagin, Fernando Rock, Maliwan Meewan, Alberto A Rascón, Lin Lin, Katherine A Cunningham, George A Lemieux, Larissa Podust, Ruben Abagyan, Kaveh Ashrafi, James H McKerrow, Conor R Caffrey
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005680 (2017)
Reliance on just one drug to treat the prevalent tropical disease, schistosomiasis, spurs the search for new drugs and drug targets. Inhibitors of human cyclic nucleotide phosphodiesterases (huPDEs), including PDE4, are under development as novel dru
Externí odkaz:
https://doaj.org/article/dfcd732569f8489bbbeb4f7f2eb8660b
Autor:
Vishal Kothari, Colin Magowan, Darren Finkelstein, Gail Lee, Chun Chen, Tim Hom, Manuel Muñoz, Dennis Monteleone, Subramanian Karur, Marta Bogaczynska, Erin Budi, Prerna Kotak, Shamra Martin, Katherine Jenkins, Simon Wong, Timothy Machajewski, Fernando Rock, Scott Turner
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c458e618606f2795c4354ebe893c9d73
https://doi.org/10.1136/jitc-2022-sitc2022.1352
https://doi.org/10.1136/jitc-2022-sitc2022.1352
Autor:
Robert T. Jacobs, Rianna Stefanakis, Nancy Tricoche, Eric E. Easom, Yvonne Freund, Kee Chong Lim, James H. McKerrow, David S. Carter, Christina A. Bulman, Brian M. Suzuki, Christopher S. Lunde, Pamela Berry, Judy A. Sakanari, Jacob J. Plattner, Chelsea Fischer, Sara Lustigman, Tsutomu Akama, Fernando Rock
Publikováno v:
ACS Infectious Diseases
The optimization of a series of benzimidazole–benzoxaborole hybrid molecules linked via a ketone that exhibit good activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river blindness,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beee7fb4c5ebfd7c32f697f2a5ce9791
https://doi.org/10.1021/acsinfecdis.9b00397
https://doi.org/10.1021/acsinfecdis.9b00397
Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Autor:
Patrick Andre, Martin Decaris, Chun Chen, Munoz Manuel, Hom Timothy, Scott M. Turner, Ming Chen, Tushar J. Desai, Megan M. Marlow, Cha Jacob, Eric Lefebvre, Steve S. Ho, Paul J. Wolters, Shaoyi Huang, Eve-Irene Lepist, Katerina Leftheris, David J Morgans, Lisa Hooi, Johanna R. Schaub, Vikram R. Rao, Jianfeng Wu, Marina Fridlib, Fernando Rock, Megi Rexhepaj, Erine H. Budi, Prerna Kotak, Gail Lee, Shamra Martin
Publikováno v:
Respiratory research, vol 22, iss 1
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs. Objectives W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8943da51a8a3553a1e3711bc9a9ed07
https://escholarship.org/uc/item/5q12m0vq
https://escholarship.org/uc/item/5q12m0vq
Autor:
Tsutomu Akama, Yvonne R. Freund, Pamela W. Berry, David S. Carter, Eric E. Easom, Kurt Jarnagin, Christopher S. Lunde, Jacob J. Plattner, Fernando Rock, Rianna Stefanakis, Chelsea Fischer, Christina A. Bulman, Kee Chong Lim, Brian M. Suzuki, Nancy Tricoche, Abdelmoneim Mansour, Utami DiCosty, Scott McCall, Ben Carson, John W. McCall, James McKerrow, Marc P. Hübner, Sabine Specht, Achim Hoerauf, Sara Lustigman, Judy A. Sakanari, Robert T. Jacobs
Publikováno v:
ACS Infectious Diseases
A series of benzimidazole–benzoxaborole hybrid molecules linked via an amide linker are described that exhibit good in vitro activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cc683f66d1ab3829297dad3581ff3c
https://pubmed.ncbi.nlm.nih.gov/31876154
https://pubmed.ncbi.nlm.nih.gov/31876154
Autor:
Eduard Gorina, Johanna R. Schaub, Chun Chen, Fernando Rock, Martin Decaris, Scott Turner, Eric Lefebvre, Eve Irene Lepist
Publikováno v:
Idiopathic interstitial pneumonias.
Integrins αVβ6 and αVβ1 are cell surface proteins that bind to and activate latent TGF-β, resulting in SMAD phosphorylation and pro-fibrotic gene expression. In IPF, both integrins are upregulated in the lung and are thought to play a role in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8b517cd46c67bff686b0a8d62ec35c8
https://doi.org/10.1183/13993003.congress-2019.pa1298
https://doi.org/10.1183/13993003.congress-2019.pa1298
Autor:
Vincent Hernandez, Liang Liu, M. R. K. Alley, Iñigo Angulo-Barturen, Manisha Mohan, Baojie Wan, Andrés Palencia, Wai Choi, Zhenkun Ma, Lisa Feng, Scott G. Franzblau, Charles Z. Ding, Maliwan Meewan, David Barros, James C. Sacchettini, Joaquín Rullas, Paul Houston, Fernando Rock, Wei Bu, Anne J. Lenaerts, Tanya Parish, Alfonso Mendoza, Xianfeng Li, Lisa K. Woolhiser, Yasheen Zhou, M. Gerard Waters, Christopher B. Cooper, Jacob J. Plattner, Suoming Zhang, Eric E. Easom, Stephen Cusack, Veronica Gruppo, Theresa O’Malley, Holly Sexton, Esther Pérez-Herrán, Thomas R. Ioerger, Yuehong Wang
Publikováno v:
Antimicrobial Agents and Chemotherapy
'Antimicrobial Agents and Chemotherapy ', vol: 60, pages: 6271-6280 (2016)
'Antimicrobial Agents and Chemotherapy ', vol: 60, pages: 6271-6280 (2016)
The recent development and spread of extensively drug-resistant and totally drug-resistant resistant (TDR) strains of Mycobacterium tuberculosis highlight the need for new antitubercular drugs. Protein synthesis inhibitors have played an important ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ebfe2cf75e49febf18965798c8ef46
http://europepmc.org/articles/PMC5038265
http://europepmc.org/articles/PMC5038265