All characteristic Raman markers of tyrosine and tyrosinate originate from phenol ring fundamental vibrations

Autor: Sergei G. Kruglik, Belén Hernández, Mahmoud Ghomi, Yves-Marie Coïc, Fernando Pflüger

Publikováno v: Journal of Raman Spectroscopy. 47:210-220

Raman data collected from free amino acid and peptide chains permit assignment of the seven markers located at approximately 1616, 1606, 1210, 1178, 850, 830, and 643 cm−1 to tyrosine. The effects induced by labile hydrogen deuteration, temperature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e3ec4aa2ba70cdd5ff2c959aede20c0
https://doi.org/10.1002/jrs.4776

Privileged hydration sites in aromatic side chains: effect on conformational equilibrium

Autor: Fernando Pflüger, Belén Hernández, Mahmoud Ghomi, Manuel Dauchez

Publikováno v: Physical Chemistry Chemical Physics
Physical Chemistry Chemical Physics, 2017, 19 (42), pp.28684-28695. ⟨10.1039/c7cp04685e⟩
Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2017, 19 (42), pp.28684-28695. ⟨10.1039/c7cp04685e⟩

Water interaction with peptide chains is one of the key structure stabilizing factors in an aqueous environment. Because of its strong polar character, water can bind to both anionic and cationic sites via electrostatic interactions. It can also act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485175281ec2557e9b17b6fdd4928c3c
https://hal.univ-reims.fr/hal-01694146

Protonation–deprotonation of the glycine backbone as followed by Raman scattering and multiconformational analysis

Autor: Belén Hernández, Mahmoud Ghomi, Fernando Pflüger, Sergei G. Kruglik

Publikováno v: Chemical Physics. 425:104-113

Because of the absence of the side chain in its chemical structure and its well defined Raman spectra, glycine was selected here to follow its backbone protonation–deprotonation. The scan of the recorded spectra in the 1800–300 cm−1 region led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71c0f9ac062dc7dbbf665c88aca7b74e
https://doi.org/10.1016/j.chemphys.2013.08.008

From bulk to plasmonic nanoparticle surfaces: The behavior of two potent therapeutic peptides, octreotide and pasireotide

Autor: Sergei G. Kruglik, Santiago Sánchez-Cortés, Yves-Marie Coïc, Régis Cohen, Fernando Pflüger, Bruno Baron, Belén Hernández, Eduardo López-Tobar, Mahmoud Ghomi, Alexandre Chenal

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Physical Chemistry Chemical Physics
Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2016, 18 (35), pp.24437-24450. ⟨10.1039/c6cp04421b⟩
Physical Chemistry Chemical Physics, 2016, 18 (35), pp.24437-24450. ⟨10.1039/c6cp04421b⟩

14 págs.; 10 figs.; 2 tabs.
Octreotide and pasireotide are two cyclic somatostatin analogues with an important clinical use in the treatment and diagnosis of neuroendocrine tumors. Herein, by the combined use of several techniques (UV-visible a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93fd13d31c9c5495829eecb766f4e035
http://hdl.handle.net/10261/151407

Protonation-deprotonation and structural dynamics of antidiabetic drug metformin

Autor: Fernando Pflüger, Belén Hernández, Régis Cohen, Mahmoud Ghomi, Sergei G. Kruglik

Publikováno v: Journal of pharmaceutical and biomedical analysis. 114

Since the late 1950s, metformin is the worldwide first-line pharmacologic treatment for type 2 diabetes. Beyond the fact that the mode of action of this drug has always been very difficult to elucidate, little is known about its physicochemical prope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36ec7dbfa094e3d213046bebe093b3f
https://pubmed.ncbi.nlm.nih.gov/26004226