Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Fernando Pardo-Manuel de Villena"'
Autor:
Jessica B. Graham, Jessica L. Swarts, Sarah R. Leist, Alexandra Schäfer, Timothy A. Bell, Pablo Hock, Joe Farrington, Ginger D. Shaw, Martin T. Ferris, Fernando Pardo-Manuel de Villena, Ralph S. Baric, Jennifer M. Lund
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109103- (2024)
Summary: The response to infection is generally heterogeneous and diverse, with some individuals remaining asymptomatic while others present with severe disease or a diverse range of symptoms. Here, we address the role of host genetics on immune phen
Externí odkaz:
https://doaj.org/article/6feb8dbc17114d739ae8c4075c31ef37
Autor:
David A Hillis, Liran Yadgary, George M Weinstock, Fernando Pardo-Manuel de Villena, Daniel Pomp, Theodore Garland
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0306397 (2024)
In various organisms, sequencing of selectively bred lines at apparent selection limits has demonstrated that genetic variation can remain at many loci, implying that evolution at the genetic level may continue even if the population mean phenotype r
Externí odkaz:
https://doaj.org/article/dcbef9f9fd17484db8959f25e2a78c89
Autor:
Tian Zhang, Gregory R. Keele, Isabela Gerdes Gyuricza, Matthew Vincent, Catherine Brunton, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Steven C. Munger, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Joao A. Paulo, Steven P. Gygi, Gary A. Churchill
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-29 (2023)
Abstract Background Phosphorylation of proteins is a key step in the regulation of many cellular processes including activation of enzymes and signaling cascades. The abundance of a phosphorylated peptide (phosphopeptide) is determined by the abundan
Externí odkaz:
https://doaj.org/article/812d1f4d20a34130b1e4a7ae5bae7fb5
Autor:
Kishore R. Alugupalli, Sudeep Kothari, Matthew P. Cravens, Justin A. Walker, Darren T. Dougharty, Gregory S. Dickinson, Louis A. Gatto, Andreas J. Bäumler, Tamding Wangdi, Darla R. Miller, Fernando Pardo-Manuel de Villena, Linda D. Siracusa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Salmonella enterica serovar Typhi is the causative agent of typhoid fever restricted to humans and does not replicate in commonly used inbred mice. Genetic variation in humans is far greater and more complex than that in a single inbred stra
Externí odkaz:
https://doaj.org/article/fb21c12f4f6245b4aadc14104da79dc1
Autor:
Marta C. Cruz Cisneros, Elizabeth J. Anderson, Brea K. Hampton, Breantié Parotti, Sanjay Sarkar, Sharon Taft-Benz, Timothy A. Bell, Matthew Blanchard, Jacob A. Dillard, Kenneth H. Dinnon, Pablo Hock, Sarah R. Leist, Emily A. Madden, Ginger D. Shaw, Ande West, Ralph S. Baric, Victoria K. Baxter, Fernando Pardo-Manuel de Villena, Mark T. Heise, Martin T. Ferris
Publikováno v:
Vaccines, Vol 12, Iss 1, p 103 (2024)
The COVID-19 pandemic led to the rapid and worldwide development of highly effective vaccines against SARS-CoV-2. However, there is significant individual-to-individual variation in vaccine efficacy due to factors including viral variants, host age,
Externí odkaz:
https://doaj.org/article/43d9495ddc00404dbe9f7ec34a4f0cf8
Autor:
Brea K Hampton, Kenneth S Plante, Alan C Whitmore, Colton L Linnertz, Emily A Madden, Kelsey E Noll, Samuel P Boyson, Breantie Parotti, James G Xenakis, Timothy A Bell, Pablo Hock, Ginger D Shaw, Fernando Pardo-Manuel de Villena, Martin T Ferris, Mark T Heise
Publikováno v:
PLoS Genetics, Vol 18, Iss 12, p e1010548 (2022)
Variation in immune homeostasis, the state in which the immune system is maintained in the absence of stimulation, is highly variable across populations. This variation is attributed to both genetic and environmental factors. However, the identity an
Externí odkaz:
https://doaj.org/article/15976cb8c23a4cb6bff3f652de673521
Autor:
Christiann H. Gaines, Sarah A. Schoenrock, Joseph Farrington, David F. Lee, Lucas J. Aponte-Collazo, Ginger D. Shaw, Darla R. Miller, Martin T. Ferris, Fernando Pardo-Manuel de Villena, Lisa M. Tarantino
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Cocaine use disorders (CUD) are devastating for affected individuals and impose a significant societal burden, but there are currently no FDA-approved therapies. The development of novel and effective treatments has been hindered by substantial gaps
Externí odkaz:
https://doaj.org/article/4393c2d6495448268539404cd26c8693
Autor:
Vasyl Zhabotynsky, Licai Huang, Paul Little, Yi-Juan Hu, Fernando Pardo-Manuel de Villena, Fei Zou, Wei Sun
Publikováno v:
PLoS Genetics, Vol 18, Iss 3, p e1010076 (2022)
Using information from allele-specific gene expression (ASE) can improve the power to map gene expression quantitative trait loci (eQTLs). However, such practice has been limited, partly due to computational challenges and lack of clarification on th
Externí odkaz:
https://doaj.org/article/e38e8e2f80794022a153e6706c4be6cf
Autor:
Nathan M. Ryan, Jessica A. Hess, Fernando Pardo-Manuel de Villena, Benjamin E. Leiby, Ayako Shimada, Lei Yu, Amir Yarmahmoodi, Nikolai Petrovsky, Bin Zhan, Maria Elena Bottazzi, Benjamin L. Makepeace, Sara Lustigman, David Abraham
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract This study tests the hypothesis that an Onchocerca volvulus vaccine, consisting of two recombinant antigens (Ov-103 and Ov-RAL-2) formulated with the combination-adjuvant Advax-2, can induce protective immunity in genetically diverse Collabo
Externí odkaz:
https://doaj.org/article/81bbb94a2d7b4f9fa3b415ead7d31ec9
Autor:
Clare M Smith, Richard E Baker, Megan K Proulx, Bibhuti B Mishra, Jarukit E Long, Sae Woong Park, Ha-Na Lee, Michael C Kiritsy, Michelle M Bellerose, Andrew J Olive, Kenan C Murphy, Kadamba Papavinasasundaram, Frederick J Boehm, Charlotte J Reames, Rachel K Meade, Brea K Hampton, Colton L Linnertz, Ginger D Shaw, Pablo Hock, Timothy A Bell, Sabine Ehrt, Dirk Schnappinger, Fernando Pardo-Manuel de Villena, Martin T Ferris, Thomas R Ioerger, Christopher M Sassetti
Publikováno v:
eLife, Vol 11 (2022)
The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the pathogen’s ability to adapt to the variable immune pressures exerted by the host. Understanding this interplay has proven difficult, largely because experimentally tra
Externí odkaz:
https://doaj.org/article/22a97844641345f9a6ecfdcfcd9e9300