Výsledky vyhledávání - "Fernando Maurício Francis Abdalla"

Akademický článek

Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus

Autor: Roberta Tancredi Francesco dos Santos, Marcelo Florencio Passos Silva, Rafael Marques Porto, Ivo Lebrun, Luís Roberto de Camargo Gonçalves, Isabel de Fátima Correia Batista, Maria Regina Lopes Sandoval, Fernando Maurício Francis Abdalla

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 26 (2020)

Abstract Background: Here, we described the presence of a neurotoxin with phospholipase A2 activity isolated from Micrurus lemniscatus venom (Mlx-8) with affinity for muscarinic acetylcholine receptors (mAChRs). Methods: The purification, molecular m

Externí odkaz: https://doaj.org/article/2e58962695444c018dce99082e253916

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Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus

Autor: Ivo Lebrun, Fernando Maurício Francis Abdalla, Maria Regina Lopes Sandoval, Rafael Marques Porto, Marcelo Florencio Passos Silva, Luis Roberto de Camargo Gonçalves, Isabel de Fátima Correia Batista, Roberta Tancredi Francesco dos Santos

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 26 (2020)
Journal of Venomous Animals and Toxins including Tropical Diseases v.26 2020
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Background: Here, we described the presence of a neurotoxin with phospholipase A2 activity isolated from Micrurus lemniscatus venom (Mlx-8) with affinity for muscarinic acetylcholine receptors (mAChRs). Methods: The purification, molecular mass deter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e288e013777dc31c17176ef6cd485b
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100301&tlng=en

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Effects of obesity induced by high-calorie diet and its treatment with exenatide on muscarinic acetylcholine receptors in rat hippocampus

Autor: Paulo Flavio Silveira, Patricia Lucio Alves, Fernando Maurício Francis Abdalla, Marcelo Florencio Passos Silva, Rafaela Fadoni Alponti

Publikováno v: Biochemical pharmacology. 169

Here, we described the effects of obesity induced by high-calorie diet and its treatment with exenatide, an anti-diabetogenic and potential anti-obesogenic drug derived from the venom of the Gila monster Heloderma suspectum, on the affinity, density,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670bbafb09dae8ae2ad8c5f8bb42c5e8
https://pubmed.ncbi.nlm.nih.gov/31491414

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Effects of Mlx-8, a phospholipase A

Autor: Roberta Tancredi Francesco, Dos Santos, Marcelo Florencio Passos, Silva, Rafael Marques, Porto, Ivo, Lebrun, Luís Roberto de Camargo, Gonçalves, Isabel de Fátima Correia, Batista, Maria Regina Lopes, Sandoval, Fernando Maurício Francis, Abdalla

Publikováno v: The Journal of Venomous Animals and Toxins Including Tropical Diseases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f50832f0a6c8dbe99da7769d47896881
https://pubmed.ncbi.nlm.nih.gov/32063920

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Anti-obesogenic and hypolipidemic effects of a glucagon-like peptide-1 receptor agonist derived from the saliva of the Gila monster

Autor: Paulo Flavio Silveira, Rafaela Fadoni Alponti, Fernando Maurício Francis Abdalla, Patricia Lucio Alves

Publikováno v: Toxicon : official journal of the International Society on Toxinology. 135

Introduction Glucagon-like peptide-1 (GLP-1) receptor (R) agonists are a class of incretin mimetic drugs that have been used for the treatment of type 2 diabetes mellitus and also considered strong candidates for the treatment of obesity. The origina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4637bdbba4a3e95e74d04bb2c7a1d443
https://pubmed.ncbi.nlm.nih.gov/28579479

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Neurotoxicity of Anhydroecgonine Methyl Ester, a Crack Cocaine Pyrolysis Product

Autor: Osvaldo Negrini-Neto, Suelen Fukuda, Livia Mendonça Munhoz Dati, Fernando Maurício Francis Abdalla, Tania Marcourakis, Daniel Carneiro Carrettiero, Mauricio Yonamine, Raphael Caio Tamborelli Garcia, Nathalia Delazeri de Carvalho, Larissa Helena Torres, Rosana Camarini, Maria Regina Lopes Sandoval, Adriana Cristina Levada-Pires, Sidnei Moura, Solange Castro Afeche

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Smoking crack cocaine involves the inhalation of cocaine and its pyrolysis product, anhydroecgonine methyl ester (AEME). There is evidence that cocaine is neurotoxic, but the neurotoxicity of AEME has never been evaluated. AEME seems to have choliner

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a9a845ef93020de2c81a5cff30a3be
https://doi.org/10.1093/toxsci/kfs140

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Characterization of a new muscarinic toxin from the venom of the Brazilian coral snake Micrurus lemniscatus in rat hippocampus

Autor: Isabel de Fátima Correia Batista, Wyara Aparecida Araújo de Medeiros, Ivo Lebrun, Daniel Coelho da Silva, Maria Regina Lopes Sandoval, Daniel C. Pimenta, Fernando Maurício Francis Abdalla

Publikováno v: Life Sciences. 89:931-938

Aims We have isolated a new muscarinic protein (MT-Mlα) from the venom of the Brazilian coral snake Micrurus lemniscatus . Main methods This small protein, which had a molecular mass of 7,048 Da, shared high sequence homology with three-finger prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14078e041759854fee35a027d81b317b
https://doi.org/10.1016/j.lfs.2011.09.024

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Estrogen receptors mediate rapid activation of phospholipase C pathway in the rat endometrium

Autor: Thaís F.G. Lucas, Carine Royer, Vivian C. Konigame, Catarina S. Porto, Fernando Maurício Francis Abdalla, Erica Rosanna Siu

Publikováno v: Steroids. 76:1582-1589

The aim of the present study was to investigate the activation of rapid signaling events by 17β-estradiol in the rat uterus. 17β-Estradiol induced a rapid increase of total [3H]-inositol phosphate accumulation in the whole uterus and endometrium, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5deb3a08f8e51568bc52d1391758357c
https://doi.org/10.1016/j.steroids.2011.09.013

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Effects of 17β-estradiol replacement on the apoptotic effects caused by ovariectomy in the rat hippocampus

Autor: Marcelo Pires de Oliveira, Sayuri Sales, Norma Yamanouye, Rosely Oliveira Godinho, Renato Tavares dos Santos Pereira, Catarina S. Porto, Milene Schmidt Luna, Rodrigo Portes Ureshino, Soraya S. Smaili, Fernando Maurício Francis Abdalla

Publikováno v: Life Sciences. 86:832-838

Aims The aim of the present study was to investigate the effects of different periods of ovariectomy and 17β-estradiol replacement on apoptotic cell death and expression of members of the Bcl-2 family in the rat hippocampus. Main methods Hippocampi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f72f135a757c8eb7c0d426524072742
https://doi.org/10.1016/j.lfs.2010.04.002

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Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces β3-adrenoceptor-mediated relaxation, causing rat detrusor overactivity

Autor: Fernando Maurício Francis Abdalla, Angelina Zanesco, Fabíola Z. Mónica, Marcelo Nicolas Muscará, A A O Bricola, Edson Antunes, Fernando R. Báu, L L Lopes Freitas, Catarina S. Porto, Simone A. Teixeira, G. De Nucci

Publikováno v: British Journal of Pharmacology. 153:1659-1668

Background and purpose: Overactive bladder is a complex and widely prevalent condition, but little is known about its physiopathology. We have carried out morphological, biochemical and functional assays to investigate the effects of long-term nitric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db9babbba257edc16ff3a3d5c70cff39
https://doi.org/10.1038/bjp.2008.39

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