Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Fernando L. Palhano"'
Autor:
Otávio Augusto Leitão Dos Santos, Rodolfo L. Carneiro, Rodrigo D. Requião, Marcelo Ribeiro-Alves, Tatiana Domitrovic, Fernando L. Palhano
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract During protein synthesis, organisms detect translation defects that induce ribosome stalling and result in protein aggregation. The Ribosome-associated Quality Control (RQC) complex, comprising TCF25, LTN1, and NEMF, is responsible for ident
Externí odkaz:
https://doaj.org/article/5283165e22dd4ec78e3d19d2bd07fc72
Publikováno v:
ACS Omega, Vol 6, Iss 12, Pp 8700-8705 (2021)
Externí odkaz:
https://doaj.org/article/fa3e20a2f19b4af1be26d7a0595f77b9
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 6255-6262 (2021)
Defensins are small proteins, usually ranging from 3 to 6 kDa, amphipathic, disulfide-rich, and with a small or even absent hydrophobic core. Since a hydrophobic core is generally found in globular proteins that fold in an aqueous solvent, the peculi
Externí odkaz:
https://doaj.org/article/364db1b553094418b55135f39f28ed16
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The accumulation of protein aggregates in human tissues is a hallmark of more than 40 diseases called amyloidoses. In seven of these disorders, the aggregation is associated with neurodegenerative processes in the central nervous system such as Alzhe
Externí odkaz:
https://doaj.org/article/f9b429e96c024f849d5bb7530f42cd6c
Autor:
Estefania P. Azevedo, Anderson B. Guimaraes-Costa, Christianne Bandeira-Melo, Leila Chimelli, Marcia Waddington-Cruz, Elvira M. Saraiva, Fernando L. Palhano, Debora Foguel
Publikováno v:
BMC Neurology, Vol 19, Iss 1, Pp 1-7 (2019)
Abstract Background Familial amyloid polyneuropathy (FAP) or ATTRv (amyloid TTR variant) amyloidosis is a fatal hereditary disease characterized by the deposition of amyloid fibrils composed of transthyretin (TTR). The current diagnosis of ATTRv reli
Externí odkaz:
https://doaj.org/article/a5ccb81299454e48be94330e84aa1ef4
Autor:
Leonardo Maciel, Dahienne Ferreira de Oliveira, Fernanda Mesquita, Hercules Antônio da Silva Souza, Leandro Oliveira, Michelle Lopes Araújo Christie, Fernando L. Palhano, Antônio Carlos Campos de Carvalho, José Hamilton Matheus Nascimento, Debora Foguel
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 1 (2021)
Background CDNF (cerebral dopamine neurotrophic factor) belongs to a new family of neurotrophic factors that exert systemic beneficial effects beyond the brain. Little is known about the role of CDNF in the cardiac context. Herein we investigated the
Externí odkaz:
https://doaj.org/article/330b013dcbb443989b2da03bd76dc2e9
Autor:
Tiago Veltri, Guilherme A. P. de Oliveira, Ewa A. Bienkiewicz, Fernando L. Palhano, Mayra de A. Marques, Adolfo H. Moraes, Jerson L. Silva, Martha M. Sorenson, Jose R. Pinto
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The hypertrophic cardiomyopathy-associated mutant D145E, in cardiac troponin C (cTnC) C-domain, causes generalised instability at multiple sites in the isolated protein. As a result, structure and function of the mutant are more susceptible
Externí odkaz:
https://doaj.org/article/24f869ff88314b1487e847a605d31809
Autor:
Otávio Augusto Leitão Dos Santos, Rodolfo L. Carneiro, Rodrigo D. Requião, Marcelo Ribeiro-Alves, Tatiana Domitrovic, Fernando L. Palhano
During protein synthesis, organisms constantly survey defective translation events that may lead to ribosome stalling with consequent ribosome collisions. Translation problems can result in misfolded protein products that sequester ribosomes into int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49be1a8ea2b5969ce8cf8249d797e368
https://doi.org/10.1101/2023.02.06.527332
https://doi.org/10.1101/2023.02.06.527332
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 12, Pp 8700-8705 (2021)
ACS Omega, Vol 6, Iss 12, Pp 8700-8705 (2021)
Thioflavin T fluorescence is a gold standard probe for the detection of amyloid fibrils. Herein, we showed that mature amyloid fibrils incubated with polyphenol epigallocatechin gallate (EGCG) present a fast reduction of the thioflavin T fluorescence
Autor:
Rodolfo L. Carneiro, Mariana H. Moreira, Fernando L. Palhano, Tatiana Domitrovic, Marcelo Ribeiro-Alves
Publikováno v:
RNA Biol
We investigated the gene-expression variation among humans by analyzing previously published mRNA-seq and ribosome footprint profiling (RP) of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation