Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Fernando L. Martin"'
Autor:
Fernando L Martin, S Jeson Sangaralingham, Brenda K Huntley, Paul M McKie, Tomoko Ichiki, Horng H Chen, Josef Korinek, Gerald E Harders, John C Burnett
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52422 (2012)
Natriuretic peptides (NPs) are cardioprotective through the activation of guanylyl cyclase (GC) receptors A and B. CD-NP, also known as cenderitide, is a novel engineered NP that was designed to uniquely serve as a first-in-class dual GC receptor ago
Externí odkaz:
https://doaj.org/article/4a4961a497004f00ba22fb4c98d3337a
Autor:
Tomoko Ichiki, Horng H. Chen, Valentina Cannone, Candace Y.W. Lee, John A. Schirger, Fernando L. Martin, Kent R. Bailey, Christopher G. Scott, John C. Burnett, Sherry L. Benike, S. Jeson Sangaralingham, Rika Kawakami
Publikováno v:
Clinical Pharmacology and Therapeutics
Cenderitide is a novel designer natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide was engineered to coactivate the two NP receptors, particulate guanyly
Autor:
Gerald E. Harders, Fernando L. Martin, Tomoko Ichiki, John C. Burnett, Paul M. McKie, Diego Bellavia, S. Jeson Sangaralingham, Amir Lerman, Christopher G. Scott, Erik L. Ritman
Publikováno v:
Circulation: Cardiovascular Imaging. 5:518-524
Background— Alterations at the level of the coronary circulation with aging may play an important role in the evolution of age-associated changes in left ventricular (LV) fibrosis and function. However these age-associated changes in the coronary v
Autor:
S. Jeson Sangaralingham, Sarah Mangiafico, John C. Burnett, Alessandro Cataliotti, Karl A. Nath, Fernando L. Martin, Gerald E. Harders, Brenda K. Huntley, Tomoko Ichiki, Margaret M. Redfield, Paul M. McKie, Elise A. Oehler, Horng H. Chen, Josef Korinek
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 302:R292-R299
Impaired renal function with loss of nephron number in chronic renal disease (CKD) is associated with increased cardiovascular morbidity and mortality. However, the structural and functional cardiac response to early and mild reduction in renal mass
Autor:
S. J Sangaralingham, Fernando L Martin, Brenda K Huntley, Tomoko Ichiki, Horng H Chen, John C Burnett
Publikováno v:
Circulation. 132
Introduction: Human and experimental studies have suggested that a decline in renal function after myocardial infarction (MI), possibly due to the activation of adverse molecular pathways, contributes to heart failure (HF) progression and poor outcom
Autor:
Joseph P. Grande, Andrew D. Rule, John C. Burnett, Alessandro Cataliotti, Denise M. Heublein, Fernando L. Martin, S. Jeson Sangaralingham, Paul M. McKie
Publikováno v:
American Journal of Physiology-Renal Physiology. 301:F943-F952
Renal aging is characterized by structural changes in the kidney including fibrosis, which contributes to the increased risk of kidney and cardiac failure in the elderly. Studies involving healthy kidney donors demonstrated subclinical age-related ne
Autor:
Paul M. McKie, John C. Burnett, Alessandro Cataliotti, Fernando L. Martin, S. Jeson Sangaralingham, Tomoko Ichiki, Guido Boerrigter, Horng H. Chen
Publikováno v:
Hypertension. 56:1152-1159
M-atrial natriuretic peptide (ANP; M-ANP) is a novel next generation 40 amino acid peptide based on ANP, which is highly resistant to enzymatic degradation and has greater and more sustained beneficial actions compared with ANP. The current study was
Autor:
John C. Burnett, Lynn K. Harstad, Horng H. Chen, Alessandro Cataliotti, Fernando L. Martin, John A. Schirger
Publikováno v:
Journal of the American College of Cardiology. 53:1302-1308
Objectives The purpose of this study was to test the hypothesis that local renal delivery of B-type natriuretic peptide (BNP) will overcome renal resistance to BNP without systemic hypotension. Background BNP has vasodilating, natriuretic, and renin-
Autor:
Lisa C. Costello-Boerrigter, Kent R. Bailey, Guido Boerrigter, John C. Burnett, John A. Schirger, Navdeep B. Malkar, Alessandro Cataliotti, Mark A. Miller, Fernando L. Martin, Horng H. Chen, Karen Polowy, Kenneth D. James
Publikováno v:
Circulation. 118:1729-1736
Background—We previously reported the feasibility of an acute, orally delivered, newly developed, conjugated form of human B-type natriuretic peptide (hBNP) in normal animals. The objective of the present study was to extend our findings and to def
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 288:R1093-R1097
A hallmark of overt congestive heart failure (CHF) is attenuated cGMP production by endogenous atrial natriuretic peptide (ANP) with renal resistance to ANP. ANP and brain natriuretic peptides (BNP) are of myocardial origin, whereas urodilatin (Uro)