High performance of an enzyme linked immunosorbent assay for American tegumentary leishmaniasis diagnosis with Leishmania (Viannia) braziliensis amastigotes membrane crude antigens.

Autor: María E Bracamonte, Agustín Moya Álvarez, Andrea M Sosa, Carlos L Hoyos, Juan J Lauthier, Silvana P Cajal, Marisa Juarez, Renato E Uncos, Fernando J Sánchez-Valdéz, Leonardo Acuña, Patricio Diosque, Miguel A Basombrío, Julio R Nasser, Yoshihisa Hashiguchi, Masataka Korenaga, Paola A Barroso, Jorge D Marco

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0232829 (2020)

The diagnosis of American tegumentary leishmaniasis (ATL) still requires the design of more effective tools. Leishmania (Viannia) braziliensis is the causal agent of the 90% of Argentinean ATL cases. Considering the current knowledge, an ELISA based

Externí odkaz: https://doaj.org/article/f8d24d2a2bc94f8e8f3bfa09f22c5461

A monoallelic deletion of the TcCRT gene increases the attenuation of a cultured Trypanosoma cruzi strain, protecting against an in vivo virulent challenge.

Autor: Fernando J Sánchez-Valdéz, Cecilia Pérez Brandán, Galia Ramírez, Alejandro D Uncos, M Paola Zago, Rubén O Cimino, Rubén M Cardozo, Jorge D Marco, Arturo Ferreira, Miguel Ángel Basombrío

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2696 (2014)

Trypanosoma cruzi calreticulin (TcCRT) is a virulence factor that binds complement C1, thus inhibiting the activation of the classical complement pathway and generating pro-phagocytic signals that increase parasite infectivity. In a previous work, we

Externí odkaz: https://doaj.org/article/4b3d1566919f447997761e1ec7ba3823

High performance of an enzyme linked immunosorbent assay for American tegumentary leishmaniasis diagnosis with Leishmania (Viannia) braziliensis amastigotes membrane crude antigens

Autor: Agustín Moya Álvarez, Jorge Diego Marco, Juan José Lauthier, Marisa Juarez, Renato E. Uncos, Yoshihisa Hashiguchi, Fernando J. Sánchez-Valdéz, Miguel A. Basombrío, Maria Estefania Bracamonte, Leonardo Acuña, Paola Andrea Barroso, Patricio Diosque, Andrea M. Sosa, Julio R. Nasser, Carlos Lorenzo Hoyos, Masataka Korenaga, Silvana P. Cajal

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0232829 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The diagnosis of American tegumentary leishmaniasis (ATL) still requires the design of more effective tools. Leishmania (Viannia) braziliensis is the causal agent of the 90% of Argentinean ATL cases. Considering the current knowledge, an ELISA based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eca5ba4a3aaa041d40667fed70d9c70
http://europepmc.org/articles/PMC7205302

Variable numbers of calreticulin genes in Trypanosoma cruzi correlate with atypical morphology and protein expression

Autor: Fernando J. Sánchez-Valdéz, Steffen Härtel, Jorge Mansilla, Andrea González, Arturo Ferreira

Publikováno v: Immunobiology. 223(12)

Trypanosoma cruzi calreticulin (TcCalr, formerly known as TcCRT), upon binding to Complement (C) C1 and ficolins, inhibits the classical and lectin pathways and promotes infectivity. This virulence correlates with the expression of TcCalr. The TcCalr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ded438f9f95e7c5ada3275a93aba96
https://pubmed.ncbi.nlm.nih.gov/30131175

Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

Autor: Dylan Orr, Wei Wang, Angel M. Padilla, Fernando J Sánchez-Valdéz, Rick L. Tarleton

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
eLife, Vol 7 (2018)

Chagas disease is one of the most harmful tropical diseases in the Americas. It affects millions of people, predominantly in Latin America. It is usually spread by kissing bugs infected with Trypanosoma cruzi parasites. It is considered a neglected t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7109a5eb201816b53ada9ee90c66bffd