Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Fernando J. Ferrer"'
Autor:
Patrik Johansson, Cecilia Krona, Soumi Kundu, Milena Doroszko, Sathishkumar Baskaran, Linnéa Schmidt, Claire Vinel, Elin Almstedt, Ramy Elgendy, Ludmila Elfineh, Caroline Gallant, Sara Lundsten, Fernando J. Ferrer Gago, Aleksi Hakkarainen, Petra Sipilä, Maria Häggblad, Ulf Martens, Bo Lundgren, Melanie M. Frigault, David P. Lane, Fredrik J. Swartling, Lene Uhrbom, Marika Nestor, Silvia Marino, Sven Nelander
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107897- (2020)
Summary: Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease presents with a complex spectrum of genomic aberrations, but the pharmacological consequences of these aberrations are partly unknown. Here, we report an
Externí odkaz:
https://doaj.org/article/cc573e6ed9f44191ba0a80782a5d717e
Autor:
Li Quan Koh, Fernando J. Ferrer-Gago
Publikováno v:
ChemPlusChem. 85:641-652
Many methods have been developed for attaching an alcohol functionality to a solid support. However, not all of these methods are used to obtain peptide alcohols. In this Minireview, we will discuss several of the most important methods and approache
Autor:
Hung Yi Kristal Kaan, Yi Han, Charles W. Johannes, Laurent Rénia, Zi Wei Chang, Brian Henry, Yaw Sing Tan, Arun Chandramohan, Yuri Frosi, Tomi K. Sawyer, Chandra S. Verma, Shiying Chen, Dawn Thean Gek Lian, Simon Ng, Tsz Ying Yuen, Jiang Shimin, Ahmad Sadruddin, Jin Huei Wong, Pietro G. A. Aronica, Christopher J. Brown, David P. Lane, Srinivasaraghavan Kannan, Prakash Arumugam, Anthony W. Partridge, Sharon Chee, Fernando J. Ferrer-Gago
Publikováno v:
Chemical Science. 11:5577-5591
Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein interactions (PPIs). Indeed, the vast diversity of chemical space conferred through their primary, secondary and tertiary structures allows these m
Publikováno v:
Chemistry – A European Journal. 26:379-383
Peptide alcohols are clinically important compounds that are underexplored in structure-activity relationship (SAR) studies in drug discovery. One reason for this underutilization is that current syntheses are laborious and time consuming. Herein, we
Autor:
Dilraj Lama, Xin Yu Koh, Le-Ann Hwang, Xiao Hui Koh, David P. Lane, Fernando J. Ferrer, Siti Aishah Binte Rahmat
Publikováno v:
Oncogene. 38:7342-7356
Recepteur d'origine nantais (RON) receptor tyrosine kinase (RTK) and its ligand, serum macrophage-stimulating protein (MSP), are well-established oncogenic drivers for tumorigenesis and metastasis. RON is often found to be alternatively spliced resul
Autor:
Kurt Neo, Arumay Pal, David P. Lane, Lakshminarayanan Rajamani, Fernando J. Ferrer, Chandra S. Verma, Alessandra Mortellaro
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Interleukin-1β (IL-1β) is a major cytokine that initiates and enhances inflammatory responses. Excessive IL-1β production is a characteristic of most chronic inflammatory diseases, including atherosclerosis, type 2 diabetes, and obesity, which aff
Autor:
Christopher J. Brown, Charles W. Johannes, Dawn Thean, Anthony W. Partridge, Tsz Ying Yuen, Yaw Sing Tan, Hung Yi Kristal Kaan, David P. Lane, Xue Er Lee, Jin Yong Neo, Yuezhen Xue, Chandra S. Verma, Fernando J. Ferrer Gago
Publikováno v:
Chemical Science
Staple composition can influence target binding and bioactivity of peptides. We present strategies to modulate E/Z ratios and access saturated analogues.
All-hydrocarbon, i, i+7 stapled peptide inhibitors of the p53-Mdm2 interaction have emerged
All-hydrocarbon, i, i+7 stapled peptide inhibitors of the p53-Mdm2 interaction have emerged
Autor:
Brad Sherborne, Andrea M. Peier, Cesear Corona, Ahmad Sadruddin, David P. Lane, Fernando J. Ferrer-Gago, Kaustav Biswas, Dawn Thean, Arun Chandramohan, Tomi K. Sawyer, Christopher J. Brown, Nicolas Boyer, Lan Ge, Tsz Ying Yuen, Lin Yan, John R. Frost, Hung Yi Kristal Kaan, Scott D. Edmondson, Jeffrey D. Hermes, Anthony W. Partridge, Xue Er Lee, Ruchia Duggal, Chad Zimprich, Matthew B. Robers, Charles W. Johannes
Publikováno v:
ACS chemical biology. 16(2)
Macrocyclic peptides open new opportunities to target intracellular protein-protein interactions (PPIs) that are often considered nondruggable by traditional small molecules. However, engineering sufficient membrane permeability into these molecules
Autor:
Li Quan Koh, Fernando J. Ferrer-Gago
Publikováno v:
Peptide Science. 113
Autor:
Patrik, Johansson, Cecilia, Krona, Soumi, Kundu, Milena, Doroszko, Sathishkumar, Baskaran, Linnéa, Schmidt, Claire, Vinel, Elin, Almstedt, Ramy, Elgendy, Ludmila, Elfineh, Caroline, Gallant, Sara, Lundsten, Fernando J, Ferrer Gago, Aleksi, Hakkarainen, Petra, Sipilä, Maria, Häggblad, Ulf, Martens, Bo, Lundgren, Melanie M, Frigault, David P, Lane, Fredrik J, Swartling, Lene, Uhrbom, Marika, Nestor, Silvia, Marino, Sven, Nelander
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107897-(2020)
Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease presents with a complex spectrum of genomic aberrations, but the pharmacological consequences of these aberrations are partly unknown. Here, we report an integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::224df7b0a96b217a92523ab1aef4f7ea
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419794
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419794